Interleukins and miRNAs intervene in the early stages of diabetic kidney disease in Type 2 diabetes mellitus patients
The involvement of proinflammatory interleukins (IL) in diabetic kidney disease of Type 2 diabetes mellitus (DM) patients was studied in relation to a particular miRNA profile. A total of 117 patients with Type 2 DM and 11 controls were enrolled in a case series study. Serum and urinary ILs and miRN...
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| Veröffentlicht in: | Biomarkers in medicine 2019-12, Vol.13 (18), p.1577-1588 |
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| container_title | Biomarkers in medicine |
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| creator | Petrica, Ligia Milas, Oana Vlad, Mihaela Vlad, Adrian Gadalean, Florica Dumitrascu, Victor Velciov, Silvia Gluhovschi, Cristina Bob, Flaviu Ursoniu, Sorin Jianu, Dragos C Matusz, Petru Pusztai, Agneta-Maria Cretu, Octavian Radu, Daniela Secara, Alina Simulescu, Anca Stefan, Maria Popescu, Roxana Vlad, Daliborca |
| description | The involvement of proinflammatory interleukins (IL) in diabetic kidney disease of Type 2 diabetes mellitus (DM) patients was studied in relation to a particular miRNA profile.
A total of 117 patients with Type 2 DM and 11 controls were enrolled in a case series study. Serum and urinary ILs and miRNAs were assessed.
IL-1α correlated with miRNA21, 124, estimated glomerular filtration rate (eGFR) and negatively with miRNA125a and 192; IL-8 with miRNA21, 124, eGFR and negatively with miRNA125a, 126 and 146a; IL-18 with miRNA21, 124 and negatively with miRNA146a, 192, eGFR.
There is an association between specific serum and urinary ILs and serum and urinary miRNAs profiles in the inflammatory response in Type 2 DM patients with diabetic kidney disease. |
| doi_str_mv | 10.2217/bmm-2019-0124 |
| format | Article |
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A total of 117 patients with Type 2 DM and 11 controls were enrolled in a case series study. Serum and urinary ILs and miRNAs were assessed.
IL-1α correlated with miRNA21, 124, estimated glomerular filtration rate (eGFR) and negatively with miRNA125a and 192; IL-8 with miRNA21, 124, eGFR and negatively with miRNA125a, 126 and 146a; IL-18 with miRNA21, 124 and negatively with miRNA146a, 192, eGFR.
There is an association between specific serum and urinary ILs and serum and urinary miRNAs profiles in the inflammatory response in Type 2 DM patients with diabetic kidney disease.</description><identifier>ISSN: 1752-0363</identifier><identifier>EISSN: 1752-0371</identifier><identifier>DOI: 10.2217/bmm-2019-0124</identifier><identifier>PMID: 31663375</identifier><language>eng</language><publisher>England: Future Medicine Ltd</publisher><subject>albuminuria ; diabetes mellitus ; interleukins ; miRNAs</subject><ispartof>Biomarkers in medicine, 2019-12, Vol.13 (18), p.1577-1588</ispartof><rights>2019 Future Medicine Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c343t-2fd8472a22eca348bc8779286735ae24cdd2a66615c866ec579abac9d89104033</citedby><cites>FETCH-LOGICAL-c343t-2fd8472a22eca348bc8779286735ae24cdd2a66615c866ec579abac9d89104033</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31663375$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Petrica, Ligia</creatorcontrib><creatorcontrib>Milas, Oana</creatorcontrib><creatorcontrib>Vlad, Mihaela</creatorcontrib><creatorcontrib>Vlad, Adrian</creatorcontrib><creatorcontrib>Gadalean, Florica</creatorcontrib><creatorcontrib>Dumitrascu, Victor</creatorcontrib><creatorcontrib>Velciov, Silvia</creatorcontrib><creatorcontrib>Gluhovschi, Cristina</creatorcontrib><creatorcontrib>Bob, Flaviu</creatorcontrib><creatorcontrib>Ursoniu, Sorin</creatorcontrib><creatorcontrib>Jianu, Dragos C</creatorcontrib><creatorcontrib>Matusz, Petru</creatorcontrib><creatorcontrib>Pusztai, Agneta-Maria</creatorcontrib><creatorcontrib>Cretu, Octavian</creatorcontrib><creatorcontrib>Radu, Daniela</creatorcontrib><creatorcontrib>Secara, Alina</creatorcontrib><creatorcontrib>Simulescu, Anca</creatorcontrib><creatorcontrib>Stefan, Maria</creatorcontrib><creatorcontrib>Popescu, Roxana</creatorcontrib><creatorcontrib>Vlad, Daliborca</creatorcontrib><title>Interleukins and miRNAs intervene in the early stages of diabetic kidney disease in Type 2 diabetes mellitus patients</title><title>Biomarkers in medicine</title><addtitle>Biomark Med</addtitle><description>The involvement of proinflammatory interleukins (IL) in diabetic kidney disease of Type 2 diabetes mellitus (DM) patients was studied in relation to a particular miRNA profile.
A total of 117 patients with Type 2 DM and 11 controls were enrolled in a case series study. Serum and urinary ILs and miRNAs were assessed.
IL-1α correlated with miRNA21, 124, estimated glomerular filtration rate (eGFR) and negatively with miRNA125a and 192; IL-8 with miRNA21, 124, eGFR and negatively with miRNA125a, 126 and 146a; IL-18 with miRNA21, 124 and negatively with miRNA146a, 192, eGFR.
There is an association between specific serum and urinary ILs and serum and urinary miRNAs profiles in the inflammatory response in Type 2 DM patients with diabetic kidney disease.</description><subject>albuminuria</subject><subject>diabetes mellitus</subject><subject>interleukins</subject><subject>miRNAs</subject><issn>1752-0363</issn><issn>1752-0371</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kD1PwzAQhi0EglIYWZFHloA_EjsZUcVHpQokVGbLcS5gmqQl5yD13-PQwsbku9PjV3cPIRecXQvB9U3ZtolgvEgYF-kBmXCdiYRJzQ__aiVPyCniB2OZ1kockxPJlZJSZxMyzLsAfQPDyndIbVfR1r883SL14_wLOogVDe9AwfbNlmKwb4B0XdPK2xKCd3Tlqw62sUew-IMvtxugYk9EuoWm8WFAurHBQxfwjBzVtkE4379T8np_t5w9Jovnh_nsdpE4mcqQiLrKUy2sEOCsTPPS5VoXIldaZhZE6qpKWKUUz1yuFLhMF7a0rqjygrOUSTklV7vcTb_-HACDaT26uI3tYD2gEZIzFaXoEU12qOvXiD3UZtP71vZbw5kZTZto2oymzWg68pf76KFsofqjf9VGoNgB9RCGHtDFyx2YXRd_eOc7-Cf8G95ajcI</recordid><startdate>20191201</startdate><enddate>20191201</enddate><creator>Petrica, Ligia</creator><creator>Milas, Oana</creator><creator>Vlad, Mihaela</creator><creator>Vlad, Adrian</creator><creator>Gadalean, Florica</creator><creator>Dumitrascu, Victor</creator><creator>Velciov, Silvia</creator><creator>Gluhovschi, Cristina</creator><creator>Bob, Flaviu</creator><creator>Ursoniu, Sorin</creator><creator>Jianu, Dragos C</creator><creator>Matusz, Petru</creator><creator>Pusztai, Agneta-Maria</creator><creator>Cretu, Octavian</creator><creator>Radu, Daniela</creator><creator>Secara, Alina</creator><creator>Simulescu, Anca</creator><creator>Stefan, Maria</creator><creator>Popescu, Roxana</creator><creator>Vlad, Daliborca</creator><general>Future Medicine Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20191201</creationdate><title>Interleukins and miRNAs intervene in the early stages of diabetic kidney disease in Type 2 diabetes mellitus patients</title><author>Petrica, Ligia ; Milas, Oana ; Vlad, Mihaela ; Vlad, Adrian ; Gadalean, Florica ; Dumitrascu, Victor ; Velciov, Silvia ; Gluhovschi, Cristina ; Bob, Flaviu ; Ursoniu, Sorin ; Jianu, Dragos C ; Matusz, Petru ; Pusztai, Agneta-Maria ; Cretu, Octavian ; Radu, Daniela ; Secara, Alina ; Simulescu, Anca ; Stefan, Maria ; Popescu, Roxana ; Vlad, Daliborca</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c343t-2fd8472a22eca348bc8779286735ae24cdd2a66615c866ec579abac9d89104033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>albuminuria</topic><topic>diabetes mellitus</topic><topic>interleukins</topic><topic>miRNAs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Petrica, Ligia</creatorcontrib><creatorcontrib>Milas, Oana</creatorcontrib><creatorcontrib>Vlad, Mihaela</creatorcontrib><creatorcontrib>Vlad, Adrian</creatorcontrib><creatorcontrib>Gadalean, Florica</creatorcontrib><creatorcontrib>Dumitrascu, Victor</creatorcontrib><creatorcontrib>Velciov, Silvia</creatorcontrib><creatorcontrib>Gluhovschi, Cristina</creatorcontrib><creatorcontrib>Bob, Flaviu</creatorcontrib><creatorcontrib>Ursoniu, Sorin</creatorcontrib><creatorcontrib>Jianu, Dragos C</creatorcontrib><creatorcontrib>Matusz, Petru</creatorcontrib><creatorcontrib>Pusztai, Agneta-Maria</creatorcontrib><creatorcontrib>Cretu, Octavian</creatorcontrib><creatorcontrib>Radu, Daniela</creatorcontrib><creatorcontrib>Secara, Alina</creatorcontrib><creatorcontrib>Simulescu, Anca</creatorcontrib><creatorcontrib>Stefan, Maria</creatorcontrib><creatorcontrib>Popescu, Roxana</creatorcontrib><creatorcontrib>Vlad, Daliborca</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biomarkers in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Petrica, Ligia</au><au>Milas, Oana</au><au>Vlad, Mihaela</au><au>Vlad, Adrian</au><au>Gadalean, Florica</au><au>Dumitrascu, Victor</au><au>Velciov, Silvia</au><au>Gluhovschi, Cristina</au><au>Bob, Flaviu</au><au>Ursoniu, Sorin</au><au>Jianu, Dragos C</au><au>Matusz, Petru</au><au>Pusztai, Agneta-Maria</au><au>Cretu, Octavian</au><au>Radu, Daniela</au><au>Secara, Alina</au><au>Simulescu, Anca</au><au>Stefan, Maria</au><au>Popescu, Roxana</au><au>Vlad, Daliborca</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interleukins and miRNAs intervene in the early stages of diabetic kidney disease in Type 2 diabetes mellitus patients</atitle><jtitle>Biomarkers in medicine</jtitle><addtitle>Biomark Med</addtitle><date>2019-12-01</date><risdate>2019</risdate><volume>13</volume><issue>18</issue><spage>1577</spage><epage>1588</epage><pages>1577-1588</pages><issn>1752-0363</issn><eissn>1752-0371</eissn><abstract>The involvement of proinflammatory interleukins (IL) in diabetic kidney disease of Type 2 diabetes mellitus (DM) patients was studied in relation to a particular miRNA profile.
A total of 117 patients with Type 2 DM and 11 controls were enrolled in a case series study. Serum and urinary ILs and miRNAs were assessed.
IL-1α correlated with miRNA21, 124, estimated glomerular filtration rate (eGFR) and negatively with miRNA125a and 192; IL-8 with miRNA21, 124, eGFR and negatively with miRNA125a, 126 and 146a; IL-18 with miRNA21, 124 and negatively with miRNA146a, 192, eGFR.
There is an association between specific serum and urinary ILs and serum and urinary miRNAs profiles in the inflammatory response in Type 2 DM patients with diabetic kidney disease.</abstract><cop>England</cop><pub>Future Medicine Ltd</pub><pmid>31663375</pmid><doi>10.2217/bmm-2019-0124</doi><tpages>12</tpages></addata></record> |
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| subjects | albuminuria diabetes mellitus interleukins miRNAs |
| title | Interleukins and miRNAs intervene in the early stages of diabetic kidney disease in Type 2 diabetes mellitus patients |
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