Macrophage autophagy regulates mitochondria‐mediated apoptosis and inhibits necrotic core formation in vulnerable plaques

The vulnerable plaque is a key distinguishing feature of atherosclerotic lesions that can cause acute atherothrombotic vascular disease. This study was designed to explore the effect of autophagy on mitochondria‐mediated macrophage apoptosis and vulnerable plaques. Here, we generated the mouse model...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2020-01, Vol.24 (1), p.260-275
Hauptverfasser:	Xiao, Qingqing, Che, Xinyu, Cai, Bin, Tao, Zhenyu, Zhang, Hengyuan, Shao, Qin, Pu, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apolipoprotein E Apolipoproteins E - deficiency Apolipoproteins E - metabolism Apoptosis Apoptosis - drug effects Arteriosclerosis Atherosclerosis Autophagy Autophagy - drug effects Biochemistry Blood clots Carotid arteries Caspase Cell Biology Cytochrome Cytochrome c Disease Progression Impairment Ketocholesterols - pharmacology Life Sciences & Biomedicine Lipids macrophage Macrophages Macrophages - drug effects Macrophages - pathology Male MAP kinase MAP Kinase Signaling System - drug effects Medicine, Research & Experimental Mice Mice, Inbred C57BL Mitochondria Mitochondria - drug effects Mitochondria - metabolism mitochondrial dysfunction Models, Biological Morphology Necrosis NF-kappa B - metabolism NMR Nuclear magnetic resonance Original Phagocytosis Plaque, Atherosclerotic - metabolism Plaque, Atherosclerotic - pathology Plaques Rapamycin RAW 264.7 Cells Research & Experimental Medicine Science & Technology Signal transduction Sirolimus - pharmacology Surgery Ultrastructure Vascular diseases Veins & arteries vulnerable plaque
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