Neutrophil Extracellular Traps Associate with Clinical Stages in Breast Cancer
Recently, neutrophil extracellular traps (NETs), three-dimensional structures formed of neutrophil enzymes such as neutrophil elastase (NE) and nuclear components (DNA), have been associated with progression in different types of cancer. However, data remain scarce in breast cancer. Thus, the aim of...
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| Veröffentlicht in: | Pathology oncology research 2020-07, Vol.26 (3), p.1781-1785 |
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| creator | Rivera-Franco, Monica M. Leon-Rodriguez, Eucario Torres-Ruiz, José J. Gómez-Martín, Diana Angles-Cano, Eduardo de la Luz Sevilla-González, María |
| description | Recently, neutrophil extracellular traps (NETs), three-dimensional structures formed of neutrophil enzymes such as neutrophil elastase (NE) and nuclear components (DNA), have been associated with progression in different types of cancer. However, data remain scarce in breast cancer. Thus, the aim of this study was to associate NETs with clinical stages of breast cancer. A prospective analysis was performed in 45 plasma samples of female patients with newly diagnosed breast cancer. NE-DNA complexes were evaluated by ELISA. Optical density was dichotomized at the median for comparisons (low and high levels of NE-DNA). The most frequent clinical stage was localized (
n
= 28, 62%) followed by regional (
n
= 13, 29%) and distant (
n
= 4, 9%). Higher levels of NE-DNA complexes were observed in regional and distant stages compared to localized disease (68% vs 32%,
p
= 0.034). No differences were observed when comparing other clinical characteristics between both groups. We demonstrated that the levels of NETs increase in proportion to the stage of the disease, observing higher levels of NE-DNA complexes in regional and metastatic disease, which coincides with the proposed mechanism by which cancer progression and metastasis might result from the formation of NETs. |
| doi_str_mv | 10.1007/s12253-019-00763-5 |
| format | Article |
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n
= 28, 62%) followed by regional (
n
= 13, 29%) and distant (
n
= 4, 9%). Higher levels of NE-DNA complexes were observed in regional and distant stages compared to localized disease (68% vs 32%,
p
= 0.034). No differences were observed when comparing other clinical characteristics between both groups. We demonstrated that the levels of NETs increase in proportion to the stage of the disease, observing higher levels of NE-DNA complexes in regional and metastatic disease, which coincides with the proposed mechanism by which cancer progression and metastasis might result from the formation of NETs.</description><identifier>ISSN: 1219-4956</identifier><identifier>EISSN: 1532-2807</identifier><identifier>DOI: 10.1007/s12253-019-00763-5</identifier><identifier>PMID: 31656990</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biomedical and Life Sciences ; Biomedicine ; Breast cancer ; Breast Neoplasms - immunology ; Breast Neoplasms - pathology ; Cancer Research ; Deoxyribonucleic acid ; Disease Progression ; DNA ; Elastase ; Extracellular Traps - immunology ; Female ; Humans ; Immunology ; Metastases ; Middle Aged ; Neoplasm Staging ; Neutrophils ; Oncology ; Optical density ; Original Article ; Pathology</subject><ispartof>Pathology oncology research, 2020-07, Vol.26 (3), p.1781-1785</ispartof><rights>Arányi Lajos Foundation 2019</rights><rights>Arányi Lajos Foundation 2019.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-7e39aeb127ba2fadf089ee948dcf6e43e3c0fc8ed56ac963d6867c5b4cac68263</citedby><cites>FETCH-LOGICAL-c375t-7e39aeb127ba2fadf089ee948dcf6e43e3c0fc8ed56ac963d6867c5b4cac68263</cites><orcidid>0000-0003-0797-9031</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12253-019-00763-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12253-019-00763-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31656990$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rivera-Franco, Monica M.</creatorcontrib><creatorcontrib>Leon-Rodriguez, Eucario</creatorcontrib><creatorcontrib>Torres-Ruiz, José J.</creatorcontrib><creatorcontrib>Gómez-Martín, Diana</creatorcontrib><creatorcontrib>Angles-Cano, Eduardo</creatorcontrib><creatorcontrib>de la Luz Sevilla-González, María</creatorcontrib><title>Neutrophil Extracellular Traps Associate with Clinical Stages in Breast Cancer</title><title>Pathology oncology research</title><addtitle>Pathol. Oncol. Res</addtitle><addtitle>Pathol Oncol Res</addtitle><description>Recently, neutrophil extracellular traps (NETs), three-dimensional structures formed of neutrophil enzymes such as neutrophil elastase (NE) and nuclear components (DNA), have been associated with progression in different types of cancer. However, data remain scarce in breast cancer. Thus, the aim of this study was to associate NETs with clinical stages of breast cancer. A prospective analysis was performed in 45 plasma samples of female patients with newly diagnosed breast cancer. NE-DNA complexes were evaluated by ELISA. Optical density was dichotomized at the median for comparisons (low and high levels of NE-DNA). The most frequent clinical stage was localized (
n
= 28, 62%) followed by regional (
n
= 13, 29%) and distant (
n
= 4, 9%). Higher levels of NE-DNA complexes were observed in regional and distant stages compared to localized disease (68% vs 32%,
p
= 0.034). No differences were observed when comparing other clinical characteristics between both groups. We demonstrated that the levels of NETs increase in proportion to the stage of the disease, observing higher levels of NE-DNA complexes in regional and metastatic disease, which coincides with the proposed mechanism by which cancer progression and metastasis might result from the formation of NETs.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - immunology</subject><subject>Breast Neoplasms - pathology</subject><subject>Cancer Research</subject><subject>Deoxyribonucleic acid</subject><subject>Disease Progression</subject><subject>DNA</subject><subject>Elastase</subject><subject>Extracellular Traps - immunology</subject><subject>Female</subject><subject>Humans</subject><subject>Immunology</subject><subject>Metastases</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Neutrophils</subject><subject>Oncology</subject><subject>Optical density</subject><subject>Original Article</subject><subject>Pathology</subject><issn>1219-4956</issn><issn>1532-2807</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1PwzAQhi0EoqXwBxiQJRaWgD9iJx5LVD6kqgyU2XKdS5sqTYqdCPj3OLSAxMBkW_fce-cHoXNKrikhyY2njAkeEaqi8JQ8EgdoSAVnEUtJchjuLJRiJeQAnXi_Jj2l5DEacCqFVIoM0WwGXeua7aqs8OS9dcZCVXWVcXjuzNbjsfeNLU0L-K1sVziryrq0psLPrVmCx2WNbx0Y3-LM1BbcKToqTOXhbH-O0MvdZJ49RNOn-8dsPI0sT0QbJcCVgQVlycKwwuQFSRWAitPcFhJiDtySwqaQC2mskjyXqUysWMTWWJkyyUfoape7dc1rB77Vm9L3q5sams5rxolKafhhEtDLP-i66VwdttMspjFhhNGeYjvKusZ7B4XeunJj3IemRPe29c62Drb1l20tQtPFPrpbbCD_afnWGwC-A3wo1Utwv7P_if0E5UmKfQ</recordid><startdate>20200701</startdate><enddate>20200701</enddate><creator>Rivera-Franco, Monica M.</creator><creator>Leon-Rodriguez, Eucario</creator><creator>Torres-Ruiz, José J.</creator><creator>Gómez-Martín, Diana</creator><creator>Angles-Cano, Eduardo</creator><creator>de la Luz Sevilla-González, María</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0797-9031</orcidid></search><sort><creationdate>20200701</creationdate><title>Neutrophil Extracellular Traps Associate with Clinical Stages in Breast Cancer</title><author>Rivera-Franco, Monica M. ; Leon-Rodriguez, Eucario ; Torres-Ruiz, José J. ; Gómez-Martín, Diana ; Angles-Cano, Eduardo ; de la Luz Sevilla-González, María</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-7e39aeb127ba2fadf089ee948dcf6e43e3c0fc8ed56ac963d6867c5b4cac68263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - immunology</topic><topic>Breast Neoplasms - pathology</topic><topic>Cancer Research</topic><topic>Deoxyribonucleic acid</topic><topic>Disease Progression</topic><topic>DNA</topic><topic>Elastase</topic><topic>Extracellular Traps - immunology</topic><topic>Female</topic><topic>Humans</topic><topic>Immunology</topic><topic>Metastases</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Neutrophils</topic><topic>Oncology</topic><topic>Optical density</topic><topic>Original Article</topic><topic>Pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rivera-Franco, Monica M.</creatorcontrib><creatorcontrib>Leon-Rodriguez, Eucario</creatorcontrib><creatorcontrib>Torres-Ruiz, José J.</creatorcontrib><creatorcontrib>Gómez-Martín, Diana</creatorcontrib><creatorcontrib>Angles-Cano, Eduardo</creatorcontrib><creatorcontrib>de la Luz Sevilla-González, María</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Pathology oncology research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rivera-Franco, Monica M.</au><au>Leon-Rodriguez, Eucario</au><au>Torres-Ruiz, José J.</au><au>Gómez-Martín, Diana</au><au>Angles-Cano, Eduardo</au><au>de la Luz Sevilla-González, María</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neutrophil Extracellular Traps Associate with Clinical Stages in Breast Cancer</atitle><jtitle>Pathology oncology research</jtitle><stitle>Pathol. Oncol. Res</stitle><addtitle>Pathol Oncol Res</addtitle><date>2020-07-01</date><risdate>2020</risdate><volume>26</volume><issue>3</issue><spage>1781</spage><epage>1785</epage><pages>1781-1785</pages><issn>1219-4956</issn><eissn>1532-2807</eissn><abstract>Recently, neutrophil extracellular traps (NETs), three-dimensional structures formed of neutrophil enzymes such as neutrophil elastase (NE) and nuclear components (DNA), have been associated with progression in different types of cancer. However, data remain scarce in breast cancer. Thus, the aim of this study was to associate NETs with clinical stages of breast cancer. A prospective analysis was performed in 45 plasma samples of female patients with newly diagnosed breast cancer. NE-DNA complexes were evaluated by ELISA. Optical density was dichotomized at the median for comparisons (low and high levels of NE-DNA). The most frequent clinical stage was localized (
n
= 28, 62%) followed by regional (
n
= 13, 29%) and distant (
n
= 4, 9%). Higher levels of NE-DNA complexes were observed in regional and distant stages compared to localized disease (68% vs 32%,
p
= 0.034). No differences were observed when comparing other clinical characteristics between both groups. We demonstrated that the levels of NETs increase in proportion to the stage of the disease, observing higher levels of NE-DNA complexes in regional and metastatic disease, which coincides with the proposed mechanism by which cancer progression and metastasis might result from the formation of NETs.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>31656990</pmid><doi>10.1007/s12253-019-00763-5</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0003-0797-9031</orcidid></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Biomedical and Life Sciences Biomedicine Breast cancer Breast Neoplasms - immunology Breast Neoplasms - pathology Cancer Research Deoxyribonucleic acid Disease Progression DNA Elastase Extracellular Traps - immunology Female Humans Immunology Metastases Middle Aged Neoplasm Staging Neutrophils Oncology Optical density Original Article Pathology |
| title | Neutrophil Extracellular Traps Associate with Clinical Stages in Breast Cancer |
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