Hemicyanine-based near-infrared fluorescent probe for the ultrasensitive detection of hNQO1 activity and discrimination of human cancer cells

NAD(P)H: Quinone Oxidoreductase 1 (hNQO1) is a cytosolic flavin two-electron reductase involved in many physiological and pathological processes that is overexpressed in many cancers and recognized as a potential cancer biomarker. However, it is still challenging for highly sensitive and selective m...

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Veröffentlicht in:	Analytica chimica acta 2019-12, Vol.1090, p.125-132
Hauptverfasser:	Zheng, Yongjun, Pan, Deng, Zhang, Yue, Zhang, Yuanjian, Shen, Yanfei
Format:	Artikel
Sprache:	eng
Schlagworte:	Biosensing Cancer cell imaging Cell Line, Tumor Enzyme Assays Fluorescent Dyes - chemical synthesis Fluorescent Dyes - chemistry Fluorescent Dyes - toxicity Hemicyanine hNQO1 Humans Indoles - chemical synthesis Indoles - chemistry Indoles - toxicity Kinetics Limit of Detection Microscopy, Confocal - methods Microscopy, Fluorescence - methods NAD(P)H Dehydrogenase (Quinone) - blood NAD(P)H Dehydrogenase (Quinone) - chemistry NIR fluorescent probe Spectrometry, Fluorescence - methods
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