Direct Transformation of N‑Protected α,β-Unsaturated γ‑Amino Amides into γ‑Lactams through a Base-Mediated Molecular Rearrangement

Here, we are reporting a single-step transformation of N-protected α,β-unsaturated γ-amino amides into 5,5-disubstituted γ-lactams through a base-mediated new molecular rearrangement. In contrast to the known N- to C­(O) cyclization of saturated γ-amino acids into corresponding γ-lactams, the new re...

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Veröffentlicht in:	Journal of organic chemistry 2019-12, Vol.84 (23), p.15145-15153
Hauptverfasser:	Ganesh Kumar, Mothukuri, Veeresh, Kuruva, Nalawade, Sachin A, Nithun, Raj V, Gopi, Hosahudya N
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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