Membranotropic and Antiradical Properties of 2-Nitroxysuccinate 3-Hydroxy-6-Methyl-2-Ethylpyridine

We studied membranotropic properties of NO donor 2-nitroxysuccinate 3-hydroxy-6-methyl-2-ethylpyridine and its structural analog succinate 3-hydroxy-6-methyl-2-ethylpyridine (Mexidol). It was shown that the compounds under study are incorporated into modeled membranes and form long-living complexes...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2019-10, Vol.167 (6), p.744-746
Hauptverfasser:	Poletaeva, D. A., Faingold, I. I., Soldatova, Yu. V., Smolina, A. V., Fedorov, B. S., Eremeev, A. B., Kotelnikova, R. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Antioxidants - pharmacology Biomedical and Life Sciences Biomedicine Cell Biology Cell Membrane - drug effects Cell Membrane - enzymology Cell Membrane - metabolism Coronary heart disease Fatty acids Free Radicals - metabolism Heart Internal Medicine Laboratory Medicine Lipid Peroxidation - drug effects Liposomes - chemistry Luminescent Measurements Male Mice Mice, Inbred C57BL Monoamine Oxidase - drug effects Monoamine Oxidase - metabolism Myocardium - chemistry Myocardium - metabolism Oxidases Pathology Phosphatidylcholines - chemistry Phosphatidylcholines - metabolism Picolines - chemistry Picolines - pharmacology Rankings
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