Physiologically Based Pharmacokinetic Modeling of Oxycodone in Children to Support Pediatric Dosing Optimization

Purpose Physiologically-based pharmacokinetic (PBPK) modeling offers a unique modality to predict age-specific pharmacokinetics. The objective of this study was to assess the ability of PBPK model to predict plasma exposure of oxycodone, a widely used opioid for pain management, in adults and childr...

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Veröffentlicht in:	Pharmaceutical research 2019-12, Vol.36 (12), p.1-12, Article 171
Hauptverfasser:	Zheng, Liang, Xu, Miao, Tang, Shi-wei, Song, Hao-xin, Jiang, Xue-hua, Wang, Ling
Format:	Artikel
Sprache:	eng
Schlagworte:	Adults Age Analysis Biochemistry Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Central nervous system depressants Children Dosage Intravenous administration Medical Law Medical research Medicine, Experimental Opioids Optimization Oral administration Oxycodone Pediatrics Pharmacokinetics Pharmacology/Toxicology Pharmacy Plasma physics Protein binding Protein folding Research Paper
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