Involvement of the PKA pathway and inhibition of voltage gated Ca2+ channels in antihyperalgesic activity of Lippia grata/β-cyclodextrin
Neuropathic pain (NP) is a difficult condition to treat because of the modest efficacy of available drugs. New treatments are required. In the study we aimed to investigate the effects of the essential oil from Lippia grata alone or complexed in β-cyclodextrin (LG or LG-βCD) on persistent inflammato...
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| creator | Siqueira-Lima, Pollyana S. Quintans, Jullyana S.S. Heimfarth, Luana Passos, Fabiolla R.S. Pereira, Erik W.M. Rezende, Marilia M. Menezes-Filho, José E.R. Barreto, Rosana S.S. Coutinho, Henrique D.M. Araújo, Adriano A.S. Medrado, Aline S. Naves, Ligia A. Bomfim, Horácio F. Lucchese, Angélica M. Gandhi, Sathiyabama Rajiv Quintans-Júnior, Lucindo J. |
| description | Neuropathic pain (NP) is a difficult condition to treat because of the modest efficacy of available drugs. New treatments are required. In the study we aimed to investigate the effects of the essential oil from Lippia grata alone or complexed in β-cyclodextrin (LG or LG-βCD) on persistent inflammatory and neuropathic pain in a mouse model. We also investigated Ca2+ currents in rat dorsal root ganglion (DRG) neurons. Male Swiss mice were treated with LG or LG/β-CD (24 mg/kg, i.g.) and their effect was evaluated using an acute inflammatory pleurisy model and nociception triggered by intraplantar injection of an agonist of the TRPs channels. We also tested their effect in chronic pain models: injection of Freund's Complete Adjuvant and partial sciatic nerve ligation (PSNL). In the pleurisy model, LG reduced the number of leukocytes and the levels of TNF-α and IL-1β. It also inhibited cinnamaldehyde and menthol-induced nociceptive behavior. The pain threshold in mechanical and thermal hyperalgesia was increased and paw edema was decreased in models of inflammatory and neuropathic pain. PSNL increased inflammatory protein contents and LG and LG-βCD restored the protein contents of TNF-α, NF-κB, and PKA, but not IL-1β and IL-10. LG inhibited voltage gated Ca2+ channels from DRG neurons. Our results suggested that LG or LG-βCD produce anti-hyperalgesic effect in chronic pain models through reductions in TNF-α levels and PKA, and inhibited voltage-gated calcium channels and may be innovative therapeutic agents for the management of NP. |
| doi_str_mv | 10.1016/j.lfs.2019.116961 |
| format | Article |
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New treatments are required. In the study we aimed to investigate the effects of the essential oil from Lippia grata alone or complexed in β-cyclodextrin (LG or LG-βCD) on persistent inflammatory and neuropathic pain in a mouse model. We also investigated Ca2+ currents in rat dorsal root ganglion (DRG) neurons. Male Swiss mice were treated with LG or LG/β-CD (24 mg/kg, i.g.) and their effect was evaluated using an acute inflammatory pleurisy model and nociception triggered by intraplantar injection of an agonist of the TRPs channels. We also tested their effect in chronic pain models: injection of Freund's Complete Adjuvant and partial sciatic nerve ligation (PSNL). In the pleurisy model, LG reduced the number of leukocytes and the levels of TNF-α and IL-1β. It also inhibited cinnamaldehyde and menthol-induced nociceptive behavior. The pain threshold in mechanical and thermal hyperalgesia was increased and paw edema was decreased in models of inflammatory and neuropathic pain. PSNL increased inflammatory protein contents and LG and LG-βCD restored the protein contents of TNF-α, NF-κB, and PKA, but not IL-1β and IL-10. LG inhibited voltage gated Ca2+ channels from DRG neurons. Our results suggested that LG or LG-βCD produce anti-hyperalgesic effect in chronic pain models through reductions in TNF-α levels and PKA, and inhibited voltage-gated calcium channels and may be innovative therapeutic agents for the management of NP.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/j.lfs.2019.116961</identifier><identifier>PMID: 31654745</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Animal models ; Animals ; beta-Cyclodextrins - metabolism ; beta-Cyclodextrins - pharmacology ; Calcium ; Calcium channels ; Calcium channels (voltage-gated) ; Calcium ions ; Channels ; Chemical compounds ; Chronic pain ; Chronic Pain - drug therapy ; Cinnamaldehyde ; Cyclodextrin ; Cyclodextrins ; Disease Models, Animal ; Dorsal root ganglia ; Dorsal root ganglion ; Edema ; Essential oils ; Ganglia, Spinal - drug effects ; Hyperalgesia - drug therapy ; Hyperalgesia - metabolism ; IL-1β ; Inflammation ; Inflammatory pain ; Injection ; Interleukin 10 ; Leukocytes ; Lippia ; Lippia - metabolism ; Male ; Medical innovations ; Menthol ; Mice ; Natural products ; Neuralgia ; Neuralgia - drug therapy ; Neurons ; NF-κB protein ; Nociception - drug effects ; Oils, Volatile - pharmacology ; Pain ; Pain - drug therapy ; Pain - metabolism ; Pain Measurement - drug effects ; Pain perception ; Pain Threshold - drug effects ; Pharmacology ; Plant Extracts - pharmacology ; Pleurisy ; Proteins ; Rats ; Rats, Wistar ; Sciatic nerve ; TNF-α ; Tumor necrosis factor-α ; β-Cyclodextrin</subject><ispartof>Life sciences (1973), 2019-12, Vol.239, p.116961-116961, Article 116961</ispartof><rights>2019 Elsevier Inc.</rights><rights>Copyright © 2019. Published by Elsevier Inc.</rights><rights>Copyright Elsevier BV Dec 15, 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c424t-8ee21b2d3b5dfe995e2fb625b0c4ac7445f83e8cf8cb44040c70ef5abc02c3b93</citedby><cites>FETCH-LOGICAL-c424t-8ee21b2d3b5dfe995e2fb625b0c4ac7445f83e8cf8cb44040c70ef5abc02c3b93</cites><orcidid>0000-0001-6507-8982 ; 0000-0001-5155-938X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0024320519308884$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31654745$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Siqueira-Lima, Pollyana S.</creatorcontrib><creatorcontrib>Quintans, Jullyana S.S.</creatorcontrib><creatorcontrib>Heimfarth, Luana</creatorcontrib><creatorcontrib>Passos, Fabiolla R.S.</creatorcontrib><creatorcontrib>Pereira, Erik W.M.</creatorcontrib><creatorcontrib>Rezende, Marilia M.</creatorcontrib><creatorcontrib>Menezes-Filho, José E.R.</creatorcontrib><creatorcontrib>Barreto, Rosana S.S.</creatorcontrib><creatorcontrib>Coutinho, Henrique D.M.</creatorcontrib><creatorcontrib>Araújo, Adriano A.S.</creatorcontrib><creatorcontrib>Medrado, Aline S.</creatorcontrib><creatorcontrib>Naves, Ligia A.</creatorcontrib><creatorcontrib>Bomfim, Horácio F.</creatorcontrib><creatorcontrib>Lucchese, Angélica M.</creatorcontrib><creatorcontrib>Gandhi, Sathiyabama Rajiv</creatorcontrib><creatorcontrib>Quintans-Júnior, Lucindo J.</creatorcontrib><title>Involvement of the PKA pathway and inhibition of voltage gated Ca2+ channels in antihyperalgesic activity of Lippia grata/β-cyclodextrin</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>Neuropathic pain (NP) is a difficult condition to treat because of the modest efficacy of available drugs. New treatments are required. In the study we aimed to investigate the effects of the essential oil from Lippia grata alone or complexed in β-cyclodextrin (LG or LG-βCD) on persistent inflammatory and neuropathic pain in a mouse model. We also investigated Ca2+ currents in rat dorsal root ganglion (DRG) neurons. Male Swiss mice were treated with LG or LG/β-CD (24 mg/kg, i.g.) and their effect was evaluated using an acute inflammatory pleurisy model and nociception triggered by intraplantar injection of an agonist of the TRPs channels. We also tested their effect in chronic pain models: injection of Freund's Complete Adjuvant and partial sciatic nerve ligation (PSNL). In the pleurisy model, LG reduced the number of leukocytes and the levels of TNF-α and IL-1β. It also inhibited cinnamaldehyde and menthol-induced nociceptive behavior. The pain threshold in mechanical and thermal hyperalgesia was increased and paw edema was decreased in models of inflammatory and neuropathic pain. PSNL increased inflammatory protein contents and LG and LG-βCD restored the protein contents of TNF-α, NF-κB, and PKA, but not IL-1β and IL-10. LG inhibited voltage gated Ca2+ channels from DRG neurons. Our results suggested that LG or LG-βCD produce anti-hyperalgesic effect in chronic pain models through reductions in TNF-α levels and PKA, and inhibited voltage-gated calcium channels and may be innovative therapeutic agents for the management of NP.</description><subject>Animal models</subject><subject>Animals</subject><subject>beta-Cyclodextrins - metabolism</subject><subject>beta-Cyclodextrins - pharmacology</subject><subject>Calcium</subject><subject>Calcium channels</subject><subject>Calcium channels (voltage-gated)</subject><subject>Calcium ions</subject><subject>Channels</subject><subject>Chemical compounds</subject><subject>Chronic pain</subject><subject>Chronic Pain - drug therapy</subject><subject>Cinnamaldehyde</subject><subject>Cyclodextrin</subject><subject>Cyclodextrins</subject><subject>Disease Models, Animal</subject><subject>Dorsal root ganglia</subject><subject>Dorsal root ganglion</subject><subject>Edema</subject><subject>Essential oils</subject><subject>Ganglia, Spinal - drug effects</subject><subject>Hyperalgesia - drug therapy</subject><subject>Hyperalgesia - metabolism</subject><subject>IL-1β</subject><subject>Inflammation</subject><subject>Inflammatory pain</subject><subject>Injection</subject><subject>Interleukin 10</subject><subject>Leukocytes</subject><subject>Lippia</subject><subject>Lippia - metabolism</subject><subject>Male</subject><subject>Medical innovations</subject><subject>Menthol</subject><subject>Mice</subject><subject>Natural products</subject><subject>Neuralgia</subject><subject>Neuralgia - drug therapy</subject><subject>Neurons</subject><subject>NF-κB protein</subject><subject>Nociception - drug effects</subject><subject>Oils, Volatile - pharmacology</subject><subject>Pain</subject><subject>Pain - drug therapy</subject><subject>Pain - metabolism</subject><subject>Pain Measurement - drug effects</subject><subject>Pain perception</subject><subject>Pain Threshold - drug effects</subject><subject>Pharmacology</subject><subject>Plant Extracts - pharmacology</subject><subject>Pleurisy</subject><subject>Proteins</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Sciatic nerve</subject><subject>TNF-α</subject><subject>Tumor necrosis factor-α</subject><subject>β-Cyclodextrin</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90ctuEzEYBWALgWhaeAA2yBIbpGpSX-ciVlXEpWqksoC1ZXv-yTiaeAbbSZlH4HV4EJ4JRyldsOjKm-8cWf9B6A0lS0poebVdDl1cMkKbJaVlU9JnaEHrqilIyelztCCEiYIzIs_QeYxbQoiUFX-JzjgtpaiEXKBfN_4wDgfYgU947HDqAX-9vcaTTv29nrH2LXa-d8YlN_qjyDzpDeCNTtDilWaX2PbaexhiljmQXD9PEPSwgegs1ja5g0vzMbt20-Q03gSd9NWf34Wd7TC28DMF51-hF50eIrx-eC_Q908fv62-FOu7zzer63VhBROpqAEYNazlRrYdNI0E1pmSSUOs0LYSQnY1h9p2tTVCEEFsRaCT2ljCLDcNv0DvT71TGH_sISa1c9HCMGgP4z4qxkmTb1MTkem7_-h23Aeff5cV542QtKmzoidlwxhjgE5Nwe10mBUl6riT2qq8kzrupE475czbh-a92UH7mPg3TAYfTiCfFQ4OgorWgbfQugA2qXZ0T9T_BQj5pWk</recordid><startdate>20191215</startdate><enddate>20191215</enddate><creator>Siqueira-Lima, Pollyana S.</creator><creator>Quintans, Jullyana S.S.</creator><creator>Heimfarth, Luana</creator><creator>Passos, Fabiolla R.S.</creator><creator>Pereira, Erik W.M.</creator><creator>Rezende, Marilia M.</creator><creator>Menezes-Filho, José E.R.</creator><creator>Barreto, Rosana S.S.</creator><creator>Coutinho, Henrique D.M.</creator><creator>Araújo, Adriano A.S.</creator><creator>Medrado, Aline S.</creator><creator>Naves, Ligia A.</creator><creator>Bomfim, Horácio F.</creator><creator>Lucchese, Angélica M.</creator><creator>Gandhi, Sathiyabama Rajiv</creator><creator>Quintans-Júnior, Lucindo J.</creator><general>Elsevier Inc</general><general>Elsevier BV</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6507-8982</orcidid><orcidid>https://orcid.org/0000-0001-5155-938X</orcidid></search><sort><creationdate>20191215</creationdate><title>Involvement of the PKA pathway and inhibition of voltage gated Ca2+ channels in antihyperalgesic activity of Lippia grata/β-cyclodextrin</title><author>Siqueira-Lima, Pollyana S. ; Quintans, Jullyana S.S. ; Heimfarth, Luana ; Passos, Fabiolla R.S. ; Pereira, Erik W.M. ; Rezende, Marilia M. ; Menezes-Filho, José E.R. ; Barreto, Rosana S.S. ; Coutinho, Henrique D.M. ; Araújo, Adriano A.S. ; Medrado, Aline S. ; Naves, Ligia A. ; Bomfim, Horácio F. ; Lucchese, Angélica M. ; Gandhi, Sathiyabama Rajiv ; Quintans-Júnior, Lucindo J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c424t-8ee21b2d3b5dfe995e2fb625b0c4ac7445f83e8cf8cb44040c70ef5abc02c3b93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animal models</topic><topic>Animals</topic><topic>beta-Cyclodextrins - metabolism</topic><topic>beta-Cyclodextrins - pharmacology</topic><topic>Calcium</topic><topic>Calcium channels</topic><topic>Calcium channels (voltage-gated)</topic><topic>Calcium ions</topic><topic>Channels</topic><topic>Chemical compounds</topic><topic>Chronic pain</topic><topic>Chronic Pain - drug therapy</topic><topic>Cinnamaldehyde</topic><topic>Cyclodextrin</topic><topic>Cyclodextrins</topic><topic>Disease Models, Animal</topic><topic>Dorsal root ganglia</topic><topic>Dorsal root ganglion</topic><topic>Edema</topic><topic>Essential oils</topic><topic>Ganglia, Spinal - drug effects</topic><topic>Hyperalgesia - drug therapy</topic><topic>Hyperalgesia - metabolism</topic><topic>IL-1β</topic><topic>Inflammation</topic><topic>Inflammatory pain</topic><topic>Injection</topic><topic>Interleukin 10</topic><topic>Leukocytes</topic><topic>Lippia</topic><topic>Lippia - metabolism</topic><topic>Male</topic><topic>Medical innovations</topic><topic>Menthol</topic><topic>Mice</topic><topic>Natural products</topic><topic>Neuralgia</topic><topic>Neuralgia - drug therapy</topic><topic>Neurons</topic><topic>NF-κB protein</topic><topic>Nociception - drug effects</topic><topic>Oils, Volatile - pharmacology</topic><topic>Pain</topic><topic>Pain - drug therapy</topic><topic>Pain - metabolism</topic><topic>Pain Measurement - drug effects</topic><topic>Pain perception</topic><topic>Pain Threshold - drug effects</topic><topic>Pharmacology</topic><topic>Plant Extracts - pharmacology</topic><topic>Pleurisy</topic><topic>Proteins</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Sciatic nerve</topic><topic>TNF-α</topic><topic>Tumor necrosis factor-α</topic><topic>β-Cyclodextrin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Siqueira-Lima, Pollyana S.</creatorcontrib><creatorcontrib>Quintans, Jullyana S.S.</creatorcontrib><creatorcontrib>Heimfarth, Luana</creatorcontrib><creatorcontrib>Passos, Fabiolla R.S.</creatorcontrib><creatorcontrib>Pereira, Erik W.M.</creatorcontrib><creatorcontrib>Rezende, Marilia M.</creatorcontrib><creatorcontrib>Menezes-Filho, José E.R.</creatorcontrib><creatorcontrib>Barreto, Rosana S.S.</creatorcontrib><creatorcontrib>Coutinho, Henrique D.M.</creatorcontrib><creatorcontrib>Araújo, Adriano A.S.</creatorcontrib><creatorcontrib>Medrado, Aline S.</creatorcontrib><creatorcontrib>Naves, Ligia A.</creatorcontrib><creatorcontrib>Bomfim, Horácio F.</creatorcontrib><creatorcontrib>Lucchese, Angélica M.</creatorcontrib><creatorcontrib>Gandhi, Sathiyabama Rajiv</creatorcontrib><creatorcontrib>Quintans-Júnior, Lucindo J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Siqueira-Lima, Pollyana S.</au><au>Quintans, Jullyana S.S.</au><au>Heimfarth, Luana</au><au>Passos, Fabiolla R.S.</au><au>Pereira, Erik W.M.</au><au>Rezende, Marilia M.</au><au>Menezes-Filho, José E.R.</au><au>Barreto, Rosana S.S.</au><au>Coutinho, Henrique D.M.</au><au>Araújo, Adriano A.S.</au><au>Medrado, Aline S.</au><au>Naves, Ligia A.</au><au>Bomfim, Horácio F.</au><au>Lucchese, Angélica M.</au><au>Gandhi, Sathiyabama Rajiv</au><au>Quintans-Júnior, Lucindo J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Involvement of the PKA pathway and inhibition of voltage gated Ca2+ channels in antihyperalgesic activity of Lippia grata/β-cyclodextrin</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>2019-12-15</date><risdate>2019</risdate><volume>239</volume><spage>116961</spage><epage>116961</epage><pages>116961-116961</pages><artnum>116961</artnum><issn>0024-3205</issn><eissn>1879-0631</eissn><abstract>Neuropathic pain (NP) is a difficult condition to treat because of the modest efficacy of available drugs. New treatments are required. In the study we aimed to investigate the effects of the essential oil from Lippia grata alone or complexed in β-cyclodextrin (LG or LG-βCD) on persistent inflammatory and neuropathic pain in a mouse model. We also investigated Ca2+ currents in rat dorsal root ganglion (DRG) neurons. Male Swiss mice were treated with LG or LG/β-CD (24 mg/kg, i.g.) and their effect was evaluated using an acute inflammatory pleurisy model and nociception triggered by intraplantar injection of an agonist of the TRPs channels. We also tested their effect in chronic pain models: injection of Freund's Complete Adjuvant and partial sciatic nerve ligation (PSNL). In the pleurisy model, LG reduced the number of leukocytes and the levels of TNF-α and IL-1β. It also inhibited cinnamaldehyde and menthol-induced nociceptive behavior. The pain threshold in mechanical and thermal hyperalgesia was increased and paw edema was decreased in models of inflammatory and neuropathic pain. PSNL increased inflammatory protein contents and LG and LG-βCD restored the protein contents of TNF-α, NF-κB, and PKA, but not IL-1β and IL-10. LG inhibited voltage gated Ca2+ channels from DRG neurons. Our results suggested that LG or LG-βCD produce anti-hyperalgesic effect in chronic pain models through reductions in TNF-α levels and PKA, and inhibited voltage-gated calcium channels and may be innovative therapeutic agents for the management of NP.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>31654745</pmid><doi>10.1016/j.lfs.2019.116961</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-6507-8982</orcidid><orcidid>https://orcid.org/0000-0001-5155-938X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0024-3205 |
| ispartof | Life sciences (1973), 2019-12, Vol.239, p.116961-116961, Article 116961 |
| issn | 0024-3205 1879-0631 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2309474804 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animal models Animals beta-Cyclodextrins - metabolism beta-Cyclodextrins - pharmacology Calcium Calcium channels Calcium channels (voltage-gated) Calcium ions Channels Chemical compounds Chronic pain Chronic Pain - drug therapy Cinnamaldehyde Cyclodextrin Cyclodextrins Disease Models, Animal Dorsal root ganglia Dorsal root ganglion Edema Essential oils Ganglia, Spinal - drug effects Hyperalgesia - drug therapy Hyperalgesia - metabolism IL-1β Inflammation Inflammatory pain Injection Interleukin 10 Leukocytes Lippia Lippia - metabolism Male Medical innovations Menthol Mice Natural products Neuralgia Neuralgia - drug therapy Neurons NF-κB protein Nociception - drug effects Oils, Volatile - pharmacology Pain Pain - drug therapy Pain - metabolism Pain Measurement - drug effects Pain perception Pain Threshold - drug effects Pharmacology Plant Extracts - pharmacology Pleurisy Proteins Rats Rats, Wistar Sciatic nerve TNF-α Tumor necrosis factor-α β-Cyclodextrin |
| title | Involvement of the PKA pathway and inhibition of voltage gated Ca2+ channels in antihyperalgesic activity of Lippia grata/β-cyclodextrin |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T03%3A34%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Involvement%20of%20the%20PKA%20pathway%20and%20inhibition%20of%20voltage%20gated%20Ca2+%20channels%20in%20antihyperalgesic%20activity%20of%20Lippia%20grata/%CE%B2-cyclodextrin&rft.jtitle=Life%20sciences%20(1973)&rft.au=Siqueira-Lima,%20Pollyana%20S.&rft.date=2019-12-15&rft.volume=239&rft.spage=116961&rft.epage=116961&rft.pages=116961-116961&rft.artnum=116961&rft.issn=0024-3205&rft.eissn=1879-0631&rft_id=info:doi/10.1016/j.lfs.2019.116961&rft_dat=%3Cproquest_cross%3E2309474804%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2333945198&rft_id=info:pmid/31654745&rft_els_id=S0024320519308884&rfr_iscdi=true |