Synthesis and biological evaluation of panaxatriol derivatives against myocardial ischemia/reperfusion injury in the rat

Panaxatriol (PT) is a natural product derived from ginseng that possesses cardioprotective effects in isolated rat hearts. To develop more potent therapeutic agents against myocardial ischemia/reperfusion (MI/R) injury from natural products, a novel series of heterocycle ring-fused panaxatriol deriv...

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Veröffentlicht in:	European journal of medicinal chemistry 2020-01, Vol.185, p.111729-111729, Article 111729
Hauptverfasser:	Wu, Qiong, Wang, Ruiying, Shi, Yang, Li, Wenchao, Li, Meng, Chen, Peng, Pan, Bowen, Wang, Qing, Li, Caifeng, Wang, Jianbing, Sun, Guibo, Sun, Xiaobo, Fu, Hongzheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Survival - drug effects Cells, Cultured Dose-Response Relationship, Drug Ginsenosides - chemical synthesis Ginsenosides - chemistry Ginsenosides - therapeutic use Heterocyclic compounds Ischemia/reperfusion injury Male Molecular Structure Myocardial Reperfusion Injury - drug therapy Myocytes, Cardiac - drug effects Panaxatriol Rats Rats, Sprague-Dawley Structure-Activity Relationship Structure-activity relationships Synthesis Troponin I - blood
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