Moderate‐intensity exercise training ameliorates the diabetes‐suppressed spermatogenesis and improves sperm parameters: Insole and simultaneous with insulin
The current study was conducted to investigate the ameliorative effect of moderate‐intensity exercise training insole and simultaneous with insulin on diabetes (DM)‐induced pathogenesis at the testicular tissue and sperm level. For this purpose, 36 mature male Wistar rats were divided into six group...
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| Veröffentlicht in: | Andrologia 2019-12, Vol.51 (11), p.e13457-n/a |
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| creator | Samadian, Zahra Tofighi, Asghar Razi, Mazdak Tolouei Azar, Javad Ghaderi Pakdel, Firouz |
| description | The current study was conducted to investigate the ameliorative effect of moderate‐intensity exercise training insole and simultaneous with insulin on diabetes (DM)‐induced pathogenesis at the testicular tissue and sperm level. For this purpose, 36 mature male Wistar rats were divided into six groups, including sedentary control (Con), exercise training (EX), sedentary experimental DM‐induced (SDM), exercise training + DM‐induced (DM + EX), insulin‐treated sedentary DM‐induced (DM + INS) and exercise training and insulin‐treated DM‐induced (DM + INS + EX) groups. Following DM induction, the 6‐week exercise training intervention (30 min of moderate‐intensity running on a treadmill, once daily [5 days/week]) was considered in EX groups. The tubular differentiation (TDI) and spermiogenesis (SPI) indices, testicular total antioxidant capacity (TAC), superoxide dismutase (SOD) and glutathione peroxidase (GPX) contents, serum testosterone and insulin levels, the apoptosis ratio and sperm parameters were assessed. The exercise in sole (EX) and simultaneous forms with INS (DM + INS + EX group) ameliorated the DM‐suppressed spermatogenesis and spermiogenesis indices, up‐regulated the serum testosterone and insulin levels, enhanced testicular SOD content, inhibited the apoptosis and improved almost all sperm parameters. In conclusion, exercise training, when simultaneously considered with insulin, fairly boosts the insulin‐induced impacts, including the up‐regulated testicular endocrine and antioxidant status, spermatogenesis and sperm quality. |
| doi_str_mv | 10.1111/and.13457 |
| format | Article |
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For this purpose, 36 mature male Wistar rats were divided into six groups, including sedentary control (Con), exercise training (EX), sedentary experimental DM‐induced (SDM), exercise training + DM‐induced (DM + EX), insulin‐treated sedentary DM‐induced (DM + INS) and exercise training and insulin‐treated DM‐induced (DM + INS + EX) groups. Following DM induction, the 6‐week exercise training intervention (30 min of moderate‐intensity running on a treadmill, once daily [5 days/week]) was considered in EX groups. The tubular differentiation (TDI) and spermiogenesis (SPI) indices, testicular total antioxidant capacity (TAC), superoxide dismutase (SOD) and glutathione peroxidase (GPX) contents, serum testosterone and insulin levels, the apoptosis ratio and sperm parameters were assessed. The exercise in sole (EX) and simultaneous forms with INS (DM + INS + EX group) ameliorated the DM‐suppressed spermatogenesis and spermiogenesis indices, up‐regulated the serum testosterone and insulin levels, enhanced testicular SOD content, inhibited the apoptosis and improved almost all sperm parameters. In conclusion, exercise training, when simultaneously considered with insulin, fairly boosts the insulin‐induced impacts, including the up‐regulated testicular endocrine and antioxidant status, spermatogenesis and sperm quality.</description><identifier>ISSN: 0303-4569</identifier><identifier>EISSN: 1439-0272</identifier><identifier>DOI: 10.1111/and.13457</identifier><identifier>PMID: 31642094</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Animals ; Antioxidants ; Apoptosis ; Blood Glucose - drug effects ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus, Experimental - blood ; Diabetes Mellitus, Experimental - pathology ; Diabetes Mellitus, Experimental - therapy ; Fitness training programs ; Glutathione peroxidase ; Hypoglycemic Agents - pharmacology ; Hypoglycemic Agents - therapeutic use ; Insulin ; Insulin - blood ; Insulin - pharmacology ; Insulin - therapeutic use ; Male ; moderate‐intensity exercise training ; Organ Size - drug effects ; Physical Conditioning, Animal ; Physical training ; Rats, Wistar ; Sperm ; Spermatogenesis ; Spermatogenesis - drug effects ; spermatozoa ; Spermatozoa - drug effects ; Spermiogenesis ; Superoxide dismutase ; Testes ; Testis - drug effects ; Testis - enzymology ; Testis - pathology ; Testosterone ; Testosterone - blood</subject><ispartof>Andrologia, 2019-12, Vol.51 (11), p.e13457-n/a</ispartof><rights>2019 Blackwell Verlag GmbH</rights><rights>2019 Blackwell Verlag GmbH.</rights><rights>Copyright © 2019 Blackwell Verlag GmbH</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3887-fd0ddb537d1b900ebac9eb0770f8839eaefdcc584dd80e4076de1a4cbc4ebfd83</citedby><cites>FETCH-LOGICAL-c3887-fd0ddb537d1b900ebac9eb0770f8839eaefdcc584dd80e4076de1a4cbc4ebfd83</cites><orcidid>0000-0002-5372-4964 ; 0000-0002-4309-4831</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fand.13457$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fand.13457$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27928,27929,45578,45579</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31642094$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Samadian, Zahra</creatorcontrib><creatorcontrib>Tofighi, Asghar</creatorcontrib><creatorcontrib>Razi, Mazdak</creatorcontrib><creatorcontrib>Tolouei Azar, Javad</creatorcontrib><creatorcontrib>Ghaderi Pakdel, Firouz</creatorcontrib><title>Moderate‐intensity exercise training ameliorates the diabetes‐suppressed spermatogenesis and improves sperm parameters: Insole and simultaneous with insulin</title><title>Andrologia</title><addtitle>Andrologia</addtitle><description>The current study was conducted to investigate the ameliorative effect of moderate‐intensity exercise training insole and simultaneous with insulin on diabetes (DM)‐induced pathogenesis at the testicular tissue and sperm level. For this purpose, 36 mature male Wistar rats were divided into six groups, including sedentary control (Con), exercise training (EX), sedentary experimental DM‐induced (SDM), exercise training + DM‐induced (DM + EX), insulin‐treated sedentary DM‐induced (DM + INS) and exercise training and insulin‐treated DM‐induced (DM + INS + EX) groups. Following DM induction, the 6‐week exercise training intervention (30 min of moderate‐intensity running on a treadmill, once daily [5 days/week]) was considered in EX groups. The tubular differentiation (TDI) and spermiogenesis (SPI) indices, testicular total antioxidant capacity (TAC), superoxide dismutase (SOD) and glutathione peroxidase (GPX) contents, serum testosterone and insulin levels, the apoptosis ratio and sperm parameters were assessed. The exercise in sole (EX) and simultaneous forms with INS (DM + INS + EX group) ameliorated the DM‐suppressed spermatogenesis and spermiogenesis indices, up‐regulated the serum testosterone and insulin levels, enhanced testicular SOD content, inhibited the apoptosis and improved almost all sperm parameters. In conclusion, exercise training, when simultaneously considered with insulin, fairly boosts the insulin‐induced impacts, including the up‐regulated testicular endocrine and antioxidant status, spermatogenesis and sperm quality.</description><subject>Animals</subject><subject>Antioxidants</subject><subject>Apoptosis</subject><subject>Blood Glucose - drug effects</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus, Experimental - blood</subject><subject>Diabetes Mellitus, Experimental - pathology</subject><subject>Diabetes Mellitus, Experimental - therapy</subject><subject>Fitness training programs</subject><subject>Glutathione peroxidase</subject><subject>Hypoglycemic Agents - pharmacology</subject><subject>Hypoglycemic Agents - therapeutic use</subject><subject>Insulin</subject><subject>Insulin - blood</subject><subject>Insulin - pharmacology</subject><subject>Insulin - therapeutic use</subject><subject>Male</subject><subject>moderate‐intensity exercise training</subject><subject>Organ Size - drug effects</subject><subject>Physical Conditioning, Animal</subject><subject>Physical training</subject><subject>Rats, Wistar</subject><subject>Sperm</subject><subject>Spermatogenesis</subject><subject>Spermatogenesis - drug effects</subject><subject>spermatozoa</subject><subject>Spermatozoa - drug effects</subject><subject>Spermiogenesis</subject><subject>Superoxide dismutase</subject><subject>Testes</subject><subject>Testis - drug effects</subject><subject>Testis - enzymology</subject><subject>Testis - pathology</subject><subject>Testosterone</subject><subject>Testosterone - blood</subject><issn>0303-4569</issn><issn>1439-0272</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1O5DAQhS00CFrAggsgS7MZFgG77fzNDgEzIPGzgXXk2BUwSpzgcoDecQSOMGebk-DuMCxGojalkr96euVHyC5nBzzWoXLmgAuZ5mtkxqUoEzbP59_IjAkmEplm5SbZQXxgsSKUS7lBNgXP5JyVckb-XPYGvArw9_XNugAObVhQeAGvLQINXlln3R1VHbS2X4JIwz1QY1UNcYhrOA6DB0QwFAfwnQr9HThAizR6o7YbfP8U11aPdFA-agXw-JOeO-xbWFFou7ENykE_In224Z5ah2Nr3TZZb1SLsPPRt8jtr9Ob47Pk4vr3-fHRRaJFUeRJY5gxdSpyw-uSMaiVLqFmec6aohAlKGiM1mkhjSkYSJZnBriSutYS6sYUYov8mHSj28cRMFSdRQ1tO3mq5oIVPONZySL6_T_0oR-9i-4ixdPlN8sltT9R2veIHppq8LZTflFxVi2Tq-Ld1Sq5yO59KI51B-aT_JdTBA4n4Nm2sPhaqTq6Opkk3wEtFaox</recordid><startdate>201912</startdate><enddate>201912</enddate><creator>Samadian, Zahra</creator><creator>Tofighi, Asghar</creator><creator>Razi, Mazdak</creator><creator>Tolouei Azar, Javad</creator><creator>Ghaderi Pakdel, Firouz</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5372-4964</orcidid><orcidid>https://orcid.org/0000-0002-4309-4831</orcidid></search><sort><creationdate>201912</creationdate><title>Moderate‐intensity exercise training ameliorates the diabetes‐suppressed spermatogenesis and improves sperm parameters: Insole and simultaneous with insulin</title><author>Samadian, Zahra ; Tofighi, Asghar ; Razi, Mazdak ; Tolouei Azar, Javad ; Ghaderi Pakdel, Firouz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3887-fd0ddb537d1b900ebac9eb0770f8839eaefdcc584dd80e4076de1a4cbc4ebfd83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animals</topic><topic>Antioxidants</topic><topic>Apoptosis</topic><topic>Blood Glucose - drug effects</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus, Experimental - blood</topic><topic>Diabetes Mellitus, Experimental - pathology</topic><topic>Diabetes Mellitus, Experimental - therapy</topic><topic>Fitness training programs</topic><topic>Glutathione peroxidase</topic><topic>Hypoglycemic Agents - pharmacology</topic><topic>Hypoglycemic Agents - therapeutic use</topic><topic>Insulin</topic><topic>Insulin - blood</topic><topic>Insulin - pharmacology</topic><topic>Insulin - therapeutic use</topic><topic>Male</topic><topic>moderate‐intensity exercise training</topic><topic>Organ Size - drug effects</topic><topic>Physical Conditioning, Animal</topic><topic>Physical training</topic><topic>Rats, Wistar</topic><topic>Sperm</topic><topic>Spermatogenesis</topic><topic>Spermatogenesis - drug effects</topic><topic>spermatozoa</topic><topic>Spermatozoa - drug effects</topic><topic>Spermiogenesis</topic><topic>Superoxide dismutase</topic><topic>Testes</topic><topic>Testis - drug effects</topic><topic>Testis - enzymology</topic><topic>Testis - pathology</topic><topic>Testosterone</topic><topic>Testosterone - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Samadian, Zahra</creatorcontrib><creatorcontrib>Tofighi, Asghar</creatorcontrib><creatorcontrib>Razi, Mazdak</creatorcontrib><creatorcontrib>Tolouei Azar, Javad</creatorcontrib><creatorcontrib>Ghaderi Pakdel, Firouz</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Andrologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Samadian, Zahra</au><au>Tofighi, Asghar</au><au>Razi, Mazdak</au><au>Tolouei Azar, Javad</au><au>Ghaderi Pakdel, Firouz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Moderate‐intensity exercise training ameliorates the diabetes‐suppressed spermatogenesis and improves sperm parameters: Insole and simultaneous with insulin</atitle><jtitle>Andrologia</jtitle><addtitle>Andrologia</addtitle><date>2019-12</date><risdate>2019</risdate><volume>51</volume><issue>11</issue><spage>e13457</spage><epage>n/a</epage><pages>e13457-n/a</pages><issn>0303-4569</issn><eissn>1439-0272</eissn><abstract>The current study was conducted to investigate the ameliorative effect of moderate‐intensity exercise training insole and simultaneous with insulin on diabetes (DM)‐induced pathogenesis at the testicular tissue and sperm level. For this purpose, 36 mature male Wistar rats were divided into six groups, including sedentary control (Con), exercise training (EX), sedentary experimental DM‐induced (SDM), exercise training + DM‐induced (DM + EX), insulin‐treated sedentary DM‐induced (DM + INS) and exercise training and insulin‐treated DM‐induced (DM + INS + EX) groups. Following DM induction, the 6‐week exercise training intervention (30 min of moderate‐intensity running on a treadmill, once daily [5 days/week]) was considered in EX groups. The tubular differentiation (TDI) and spermiogenesis (SPI) indices, testicular total antioxidant capacity (TAC), superoxide dismutase (SOD) and glutathione peroxidase (GPX) contents, serum testosterone and insulin levels, the apoptosis ratio and sperm parameters were assessed. The exercise in sole (EX) and simultaneous forms with INS (DM + INS + EX group) ameliorated the DM‐suppressed spermatogenesis and spermiogenesis indices, up‐regulated the serum testosterone and insulin levels, enhanced testicular SOD content, inhibited the apoptosis and improved almost all sperm parameters. In conclusion, exercise training, when simultaneously considered with insulin, fairly boosts the insulin‐induced impacts, including the up‐regulated testicular endocrine and antioxidant status, spermatogenesis and sperm quality.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>31642094</pmid><doi>10.1111/and.13457</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-5372-4964</orcidid><orcidid>https://orcid.org/0000-0002-4309-4831</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Antioxidants Apoptosis Blood Glucose - drug effects Diabetes Diabetes mellitus Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - pathology Diabetes Mellitus, Experimental - therapy Fitness training programs Glutathione peroxidase Hypoglycemic Agents - pharmacology Hypoglycemic Agents - therapeutic use Insulin Insulin - blood Insulin - pharmacology Insulin - therapeutic use Male moderate‐intensity exercise training Organ Size - drug effects Physical Conditioning, Animal Physical training Rats, Wistar Sperm Spermatogenesis Spermatogenesis - drug effects spermatozoa Spermatozoa - drug effects Spermiogenesis Superoxide dismutase Testes Testis - drug effects Testis - enzymology Testis - pathology Testosterone Testosterone - blood |
| title | Moderate‐intensity exercise training ameliorates the diabetes‐suppressed spermatogenesis and improves sperm parameters: Insole and simultaneous with insulin |
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