Aspirin promotes tenogenic differentiation of tendon stem cells and facilitates tendinopathy healing through regulating the GDF7/Smad1/5 signaling pathway

Tendinopathy is a common musculoskeletal system disorder in sports medicine, but regeneration ability of injury tendon is limited. Tendon stem cells (TSCs) have shown the definitive treatment evidence for tendinopathy and tendon injuries due to their tenogenesis capacity. Aspirin, as the representat...

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Veröffentlicht in:	Journal of cellular physiology 2020-05, Vol.235 (5), p.4778-4789
Hauptverfasser:	Wang, Yunjiao, He, Gang, Tang, Hong, Shi, Youxing, Zhu, Min, Kang, Xia, Bian, Xuting, Lyu, Jingtong, Zhou, Mei, Yang, Mingyu, Mu, Miduo, Chen, Wan, Zhou, Binghua, Yuan, Chengsong, Zhang, Jiqiang, Tang, Kanglai
Format:	Artikel
Sprache:	eng
Schlagworte:	Achilles Tendon - drug effects Achilles Tendon - metabolism Achilles Tendon - pathology Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Aspirin Aspirin - pharmacology Biomechanics Bone Morphogenetic Proteins - genetics Bone Morphogenetic Proteins - metabolism Cell differentiation Cell Differentiation - drug effects Cells, Cultured Differentiation Disease Models, Animal Gene sequencing Growth Differentiation Factors - genetics Growth Differentiation Factors - metabolism Healing Inflammation Injuries Injury prevention Male Mechanical properties Musculoskeletal system NSAIDs Rats, Sprague-Dawley Regeneration Ribonucleic acid RNA Signal Transduction Signaling Smad1 Protein - genetics Smad1 Protein - metabolism Smad5 Protein - genetics Smad5 Protein - metabolism Sports medicine stem cell differentiation Stem cells Stem Cells - drug effects Stem Cells - metabolism Stem Cells - pathology Tendinopathy - drug therapy Tendinopathy - genetics Tendinopathy - metabolism Tendinopathy - pathology tendon injury healing Wound Healing - drug effects
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