The PNPLA3 I148M variant promotes lipid-induced hepatocyte secretion of CXC chemokines establishing a tumorigenic milieu

The I148M variant of the Patatin-like phospholipase domain-containing 3 (PNPLA3) protein is associated with an increased risk for liver inflammation and hepatocellular carcinoma (HCC), but the underlying mechanism is unknown. We hypothesized that enhanced CXC chemokine secretion mediates hepatic inf...

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Veröffentlicht in:	Journal of molecular medicine (Berlin, Germany) Germany), 2019-11, Vol.97 (11), p.1589-1600
Hauptverfasser:	Nischalke, Hans Dieter, Lutz, Philipp, Bartok, Eva, Krämer, Benjamin, Langhans, Bettina, Frizler, Regina, Berg, Thomas, Hampe, Jochen, Buch, Stephan, Datz, Christian, Stickel, Felix, Hartmann, Gunther, Strassburg, Christian P., Nattermann, Jacob, Spengler, Ulrich
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Biomedical and Life Sciences Biomedicine Blood cells Cell culture Cell proliferation Chemokines Cirrhosis CXC chemokines Cytokines Enzyme-linked immunosorbent assay Hepatocellular carcinoma Hepatocytes Hepatoma Human Genetics Inflammation Interleukin 8 Internal Medicine Leukocyte migration Lipids Liver Liver cancer Liver cirrhosis Liver diseases Molecular Medicine Original Article Phospholipase Stimulation
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