Suppressive effects of the sodium‑glucose cotransporter 2 inhibitor tofogliflozin on colorectal tumorigenesis in diabetic and obese mice

Sodium‑glucose cotransporter 2 inhibitors were developed for the treatment of diabetes mellitus. Although recent studies have indicated that sodium‑glucose cotransporter 2 inhibitors have suppressive effects on several types of cancer, their effects against colorectal cancer remain unknown. The purp...

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Veröffentlicht in:	Oncology reports 2019-12, Vol.42 (6), p.2797-2805
Hauptverfasser:	Kato, Junichi, Shirakami, Yohei, Ohnishi, Masaya, Mizutani, Taku, Kubota, Masaya, Sakai, Hiroyasu, Ibuka, Takashi, Tanaka, Takuji, Shimizu, Masahito
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose tissue Analysis Animals Azoxymethane - toxicity Benzhydryl Compounds - pharmacology Blood glucose Blood Glucose - drug effects Cancer cells Cancer research Carcinogenesis - drug effects Cell growth Cell Proliferation - drug effects Colorectal cancer Colorectal Neoplasms - chemically induced Colorectal Neoplasms - drug therapy Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Diabetes Diabetes mellitus Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - genetics Diabetes therapy Drinking water Drug therapy Experiments Gene Expression Regulation, Neoplastic - drug effects Glucose Glucosides - pharmacology House mouse Humans Hypoglycemic Agents - pharmacology Inflammation Insulin Insulin resistance Macrophages Messenger RNA Metabolism Mice Mice, Inbred NOD - genetics Mice, Obese - genetics Obesity Obesity - drug therapy Obesity - genetics RNA Sodium-Glucose Transporter 2 - genetics Sodium-Glucose Transporter 2 Inhibitors - pharmacology Studies Tumor Necrosis Factor-alpha - genetics Tumorigenesis Tumors Type 2 diabetes Water
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