Saturated fatty acid is a principal cause of anxiety-like behavior in diet-induced obese rats in relation to serum lysophosphatidyl choline level

Background Obesity is considered to be a risk factor for neurodegenerative- and psychiatric- diseases including Alzheimer’s disease, schizophrenia, and depression. A high-lard diet is widely used to induce obesity in model animal experiments, which also leads to anxiety-like and depression-like beha...

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Veröffentlicht in:	International Journal of Obesity 2020-03, Vol.44 (3), p.727-738
Hauptverfasser:	Nakajima, Shingo, Fukasawa, Keiko, Gotoh, Mari, Murakami-Murofushi, Kimiko, Kunugi, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	101/58 631/378 631/443/319/1642/393 631/45/608 82/16 Adipose tissue Alzheimer's disease Animal research Animals Anxiety Anxiety - chemically induced Behavior Behavior, Animal - drug effects Body weight Choline Cognitive ability Complications and side effects Diet Diet, High-Fat Dietary fat Disease Models, Animal Eicosapentaenoic acid Epidemiology Fatty acids Fatty Acids - pharmacology Gene expression Glutamate receptors Glutamic acid transporter Health aspects Health Promotion and Disease Prevention High fat diet Hormones Insulin Internal Medicine Lecithin Leptin Lipid composition Lipids Liquid chromatography Lysophosphatidylcholines - blood Male Mass spectrometry Mass spectroscopy Medicine Medicine & Public Health Mental depression Mental disorders Metabolic Diseases mRNA Neurodegenerative diseases Neurotransmitters Obesity Obesity - physiopathology Oils & fats Olive oil Open-field behavior Prefrontal cortex Psychological aspects Public Health Rats Rats, Sprague-Dawley Risk analysis Risk factors Schizophrenia Social behavior Social factors Social interaction Sucrose Sucrose - pharmacology Sugar
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