The Iberian pig fed with high-fat diet: a model of renal disease in obesity and metabolic syndrome
Background The pathogenesis of renal disease in the context of overweight/obesity, metabolic syndrome, and insulin resistance is not completely understood. This may be due to the lack of a definitive animal model of disease, which limits our understanding of obesity-induced renal damage. We evaluate...
Gespeichert in:
| Veröffentlicht in: | International Journal of Obesity 2020-02, Vol.44 (2), p.457-465 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 465 |
|---|---|
| container_issue | 2 |
| container_start_page | 457 |
| container_title | International Journal of Obesity |
| container_volume | 44 |
| creator | Rodríguez, Rosa Rodríguez González-Bulnes, Antonio Garcia-Contreras, Consolacion Elena Rodriguez-Rodriguez, Ana Astiz, Susana Vazquez-Gomez, Marta Luis Pesantez, Jose Isabel, Beatriz Salido-Ruiz, Eduardo González, Jorge Donate Correa, Javier Luis-Lima, Sergio Porrini, Esteban |
| description | Background
The pathogenesis of renal disease in the context of overweight/obesity, metabolic syndrome, and insulin resistance is not completely understood. This may be due to the lack of a definitive animal model of disease, which limits our understanding of obesity-induced renal damage. We evaluated the changes in renal histology and lipid deposits induced by obesity in a model of insulin resistance: the Iberian swine fed with fat-enriched food.
Methods
Twenty-eight female sows were randomized to standard (SD) or high-fat diet (HFD: 6.8% of saturated fat) for 100 days. Weight, adiposity, analytics, oral glucose tolerance tests, and measured renal function were determined. Renal histology and lipid deposits in renal tissue were analyzed.
Results
Animals on HFD developed obesity, hypertension, high levels of LDL cholesterol, triglycerides, insulin resistance, and glomerular hyperfiltration. No animal developed overt diabetes. Animals on HFD showed “diabetoid changes”, including mesangial expansion [21.40% ± 4 vs.13.20% ± 4.0,
p
|
| doi_str_mv | 10.1038/s41366-019-0434-9 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2307735912</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A613154024</galeid><sourcerecordid>A613154024</sourcerecordid><originalsourceid>FETCH-LOGICAL-c541t-bcc97f2ac4bf0ad6a522fb5fb5a807245e9b78a051302bf3fbca028a53a3f8b3</originalsourceid><addsrcrecordid>eNp9kl1rFDEUhgdR7Fr9Ad5IQBBvpuZzMuNdKX4UCt7sfTiZOdlJmZmsSQbZf98sW60VlYQETp73hPfwVtVrRi8YFe2HJJlompqyrqZSyLp7Um2Y1E2tZKefVhsqqK6patRZ9SKlW0qpUpQ_r84Ea0QjdLOp7HZEcm0xeljI3u-Iw4H88Hkko9-NtYNMBo_5IwEyhwEnEhyJuMBUygkhIfELCRaTzwcCy0BmzGDD5HuSDssQw4wvq2cOpoSv7u_zavv50_bqa33z7cv11eVN3SvJcm37vtOOQy-tozA0oDh3VpUNLdVcKuysboEqJii3TjjbA-UtKAHCtVacV-9PbfcxfF8xZTP71OM0wYJhTYaXYWihOsYL-vYP9DassZgqVBmfLrPs2v9SQlFRDqUfqB1MaPziQo7QH782lw0TTEnKZaEu_kKVNeDs-7Cg86X-SPDuN8GIMOUxhWnNPizpMchOYB9DShGd2Uc_QzwYRs0xJeaUElNSYo4pMV3RvLl3ttoZh1-Kn7EoAD8BqTwtO4wP1v_d9Q4Po8NK</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2350323557</pqid></control><display><type>article</type><title>The Iberian pig fed with high-fat diet: a model of renal disease in obesity and metabolic syndrome</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><source>Nature Journals Online</source><creator>Rodríguez, Rosa Rodríguez ; González-Bulnes, Antonio ; Garcia-Contreras, Consolacion ; Elena Rodriguez-Rodriguez, Ana ; Astiz, Susana ; Vazquez-Gomez, Marta ; Luis Pesantez, Jose ; Isabel, Beatriz ; Salido-Ruiz, Eduardo ; González, Jorge ; Donate Correa, Javier ; Luis-Lima, Sergio ; Porrini, Esteban</creator><creatorcontrib>Rodríguez, Rosa Rodríguez ; González-Bulnes, Antonio ; Garcia-Contreras, Consolacion ; Elena Rodriguez-Rodriguez, Ana ; Astiz, Susana ; Vazquez-Gomez, Marta ; Luis Pesantez, Jose ; Isabel, Beatriz ; Salido-Ruiz, Eduardo ; González, Jorge ; Donate Correa, Javier ; Luis-Lima, Sergio ; Porrini, Esteban</creatorcontrib><description>Background
The pathogenesis of renal disease in the context of overweight/obesity, metabolic syndrome, and insulin resistance is not completely understood. This may be due to the lack of a definitive animal model of disease, which limits our understanding of obesity-induced renal damage. We evaluated the changes in renal histology and lipid deposits induced by obesity in a model of insulin resistance: the Iberian swine fed with fat-enriched food.
Methods
Twenty-eight female sows were randomized to standard (SD) or high-fat diet (HFD: 6.8% of saturated fat) for 100 days. Weight, adiposity, analytics, oral glucose tolerance tests, and measured renal function were determined. Renal histology and lipid deposits in renal tissue were analyzed.
Results
Animals on HFD developed obesity, hypertension, high levels of LDL cholesterol, triglycerides, insulin resistance, and glomerular hyperfiltration. No animal developed overt diabetes. Animals on HFD showed “diabetoid changes”, including mesangial expansion [21.40% ± 4 vs.13.20% ± 4.0,
p
< 0.0001], nodular glomerulosclerosis [7.40% ± 7, 0.75 vs. 2.40% ± 4.7,
p
= 0.02], and glomerulomegaly (18% vs. 10%,
p
= 0.010) than those on SD. Tubular atrophy, interstitial fibrosis, inflammation, arteriolar hyalinosis, or fibrointimal thickening were mild and similar between groups. Triglyceride content in renal tissue was higher in animals on HFD than in SD (15.4% ± 0.5 vs. 12.7% ± 0.7;
p
< 0.01).
Conclusions
Iberian pigs fed with fat-enriched food showed diabetoid changes and glomerulomegaly as observed in obese humans making this model suitable to study obesity-induced renal disease.</description><identifier>ISSN: 0307-0565</identifier><identifier>EISSN: 1476-5497</identifier><identifier>DOI: 10.1038/s41366-019-0434-9</identifier><identifier>PMID: 31636376</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>101/58 ; 692/163/2743/2037 ; 692/163/2743/393 ; 82/16 ; 96/63 ; Adipose tissue ; Analysis ; Animal diseases ; Animal feeding and feeds ; Animal models ; Animals ; Atrophy ; Body weight ; Cholesterol ; Cholesterol, LDL - blood ; Damage assessment ; Dextrose ; Diabetes mellitus ; Diet ; Diet, High-Fat ; Disease control ; Disease Models, Animal ; Enriched foods ; Epidemiology ; Female ; Fibrosis ; Food ; Glucose ; Glucose tolerance ; Health Promotion and Disease Prevention ; High fat diet ; Histology ; Hogs ; Hyperfiltration ; Hypertension ; Insulin ; Insulin Resistance ; Internal Medicine ; Kidney - pathology ; Kidney - physiopathology ; Kidney diseases ; Kidney Diseases - etiology ; Kidney Diseases - pathology ; Kidney Diseases - physiopathology ; Lipids ; Low density lipoprotein ; Low density lipoproteins ; Medical research ; Medicine ; Medicine & Public Health ; Medicine, Experimental ; Metabolic Diseases ; Metabolic disorders ; Metabolic syndrome ; Metabolic Syndrome - complications ; Obesity ; Obesity - complications ; Overweight ; Pathogenesis ; Public Health ; Renal function ; Swine ; Thickening ; Trans fatty acids ; Triglycerides ; Triglycerides - blood</subject><ispartof>International Journal of Obesity, 2020-02, Vol.44 (2), p.457-465</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Limited 2019</rights><rights>COPYRIGHT 2020 Nature Publishing Group</rights><rights>2019© The Author(s), under exclusive licence to Springer Nature Limited 2019</rights><rights>The Author(s), under exclusive licence to Springer Nature Limited 2019.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c541t-bcc97f2ac4bf0ad6a522fb5fb5a807245e9b78a051302bf3fbca028a53a3f8b3</citedby><cites>FETCH-LOGICAL-c541t-bcc97f2ac4bf0ad6a522fb5fb5a807245e9b78a051302bf3fbca028a53a3f8b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41366-019-0434-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41366-019-0434-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31636376$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rodríguez, Rosa Rodríguez</creatorcontrib><creatorcontrib>González-Bulnes, Antonio</creatorcontrib><creatorcontrib>Garcia-Contreras, Consolacion</creatorcontrib><creatorcontrib>Elena Rodriguez-Rodriguez, Ana</creatorcontrib><creatorcontrib>Astiz, Susana</creatorcontrib><creatorcontrib>Vazquez-Gomez, Marta</creatorcontrib><creatorcontrib>Luis Pesantez, Jose</creatorcontrib><creatorcontrib>Isabel, Beatriz</creatorcontrib><creatorcontrib>Salido-Ruiz, Eduardo</creatorcontrib><creatorcontrib>González, Jorge</creatorcontrib><creatorcontrib>Donate Correa, Javier</creatorcontrib><creatorcontrib>Luis-Lima, Sergio</creatorcontrib><creatorcontrib>Porrini, Esteban</creatorcontrib><title>The Iberian pig fed with high-fat diet: a model of renal disease in obesity and metabolic syndrome</title><title>International Journal of Obesity</title><addtitle>Int J Obes</addtitle><addtitle>Int J Obes (Lond)</addtitle><description>Background
The pathogenesis of renal disease in the context of overweight/obesity, metabolic syndrome, and insulin resistance is not completely understood. This may be due to the lack of a definitive animal model of disease, which limits our understanding of obesity-induced renal damage. We evaluated the changes in renal histology and lipid deposits induced by obesity in a model of insulin resistance: the Iberian swine fed with fat-enriched food.
Methods
Twenty-eight female sows were randomized to standard (SD) or high-fat diet (HFD: 6.8% of saturated fat) for 100 days. Weight, adiposity, analytics, oral glucose tolerance tests, and measured renal function were determined. Renal histology and lipid deposits in renal tissue were analyzed.
Results
Animals on HFD developed obesity, hypertension, high levels of LDL cholesterol, triglycerides, insulin resistance, and glomerular hyperfiltration. No animal developed overt diabetes. Animals on HFD showed “diabetoid changes”, including mesangial expansion [21.40% ± 4 vs.13.20% ± 4.0,
p
< 0.0001], nodular glomerulosclerosis [7.40% ± 7, 0.75 vs. 2.40% ± 4.7,
p
= 0.02], and glomerulomegaly (18% vs. 10%,
p
= 0.010) than those on SD. Tubular atrophy, interstitial fibrosis, inflammation, arteriolar hyalinosis, or fibrointimal thickening were mild and similar between groups. Triglyceride content in renal tissue was higher in animals on HFD than in SD (15.4% ± 0.5 vs. 12.7% ± 0.7;
p
< 0.01).
Conclusions
Iberian pigs fed with fat-enriched food showed diabetoid changes and glomerulomegaly as observed in obese humans making this model suitable to study obesity-induced renal disease.</description><subject>101/58</subject><subject>692/163/2743/2037</subject><subject>692/163/2743/393</subject><subject>82/16</subject><subject>96/63</subject><subject>Adipose tissue</subject><subject>Analysis</subject><subject>Animal diseases</subject><subject>Animal feeding and feeds</subject><subject>Animal models</subject><subject>Animals</subject><subject>Atrophy</subject><subject>Body weight</subject><subject>Cholesterol</subject><subject>Cholesterol, LDL - blood</subject><subject>Damage assessment</subject><subject>Dextrose</subject><subject>Diabetes mellitus</subject><subject>Diet</subject><subject>Diet, High-Fat</subject><subject>Disease control</subject><subject>Disease Models, Animal</subject><subject>Enriched foods</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Fibrosis</subject><subject>Food</subject><subject>Glucose</subject><subject>Glucose tolerance</subject><subject>Health Promotion and Disease Prevention</subject><subject>High fat diet</subject><subject>Histology</subject><subject>Hogs</subject><subject>Hyperfiltration</subject><subject>Hypertension</subject><subject>Insulin</subject><subject>Insulin Resistance</subject><subject>Internal Medicine</subject><subject>Kidney - pathology</subject><subject>Kidney - physiopathology</subject><subject>Kidney diseases</subject><subject>Kidney Diseases - etiology</subject><subject>Kidney Diseases - pathology</subject><subject>Kidney Diseases - physiopathology</subject><subject>Lipids</subject><subject>Low density lipoprotein</subject><subject>Low density lipoproteins</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Medicine, Experimental</subject><subject>Metabolic Diseases</subject><subject>Metabolic disorders</subject><subject>Metabolic syndrome</subject><subject>Metabolic Syndrome - complications</subject><subject>Obesity</subject><subject>Obesity - complications</subject><subject>Overweight</subject><subject>Pathogenesis</subject><subject>Public Health</subject><subject>Renal function</subject><subject>Swine</subject><subject>Thickening</subject><subject>Trans fatty acids</subject><subject>Triglycerides</subject><subject>Triglycerides - blood</subject><issn>0307-0565</issn><issn>1476-5497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kl1rFDEUhgdR7Fr9Ad5IQBBvpuZzMuNdKX4UCt7sfTiZOdlJmZmsSQbZf98sW60VlYQETp73hPfwVtVrRi8YFe2HJJlompqyrqZSyLp7Um2Y1E2tZKefVhsqqK6patRZ9SKlW0qpUpQ_r84Ea0QjdLOp7HZEcm0xeljI3u-Iw4H88Hkko9-NtYNMBo_5IwEyhwEnEhyJuMBUygkhIfELCRaTzwcCy0BmzGDD5HuSDssQw4wvq2cOpoSv7u_zavv50_bqa33z7cv11eVN3SvJcm37vtOOQy-tozA0oDh3VpUNLdVcKuysboEqJii3TjjbA-UtKAHCtVacV-9PbfcxfF8xZTP71OM0wYJhTYaXYWihOsYL-vYP9DassZgqVBmfLrPs2v9SQlFRDqUfqB1MaPziQo7QH782lw0TTEnKZaEu_kKVNeDs-7Cg86X-SPDuN8GIMOUxhWnNPizpMchOYB9DShGd2Uc_QzwYRs0xJeaUElNSYo4pMV3RvLl3ttoZh1-Kn7EoAD8BqTwtO4wP1v_d9Q4Po8NK</recordid><startdate>20200201</startdate><enddate>20200201</enddate><creator>Rodríguez, Rosa Rodríguez</creator><creator>González-Bulnes, Antonio</creator><creator>Garcia-Contreras, Consolacion</creator><creator>Elena Rodriguez-Rodriguez, Ana</creator><creator>Astiz, Susana</creator><creator>Vazquez-Gomez, Marta</creator><creator>Luis Pesantez, Jose</creator><creator>Isabel, Beatriz</creator><creator>Salido-Ruiz, Eduardo</creator><creator>González, Jorge</creator><creator>Donate Correa, Javier</creator><creator>Luis-Lima, Sergio</creator><creator>Porrini, Esteban</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T2</scope><scope>7TK</scope><scope>7TS</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20200201</creationdate><title>The Iberian pig fed with high-fat diet: a model of renal disease in obesity and metabolic syndrome</title><author>Rodríguez, Rosa Rodríguez ; González-Bulnes, Antonio ; Garcia-Contreras, Consolacion ; Elena Rodriguez-Rodriguez, Ana ; Astiz, Susana ; Vazquez-Gomez, Marta ; Luis Pesantez, Jose ; Isabel, Beatriz ; Salido-Ruiz, Eduardo ; González, Jorge ; Donate Correa, Javier ; Luis-Lima, Sergio ; Porrini, Esteban</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c541t-bcc97f2ac4bf0ad6a522fb5fb5a807245e9b78a051302bf3fbca028a53a3f8b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>101/58</topic><topic>692/163/2743/2037</topic><topic>692/163/2743/393</topic><topic>82/16</topic><topic>96/63</topic><topic>Adipose tissue</topic><topic>Analysis</topic><topic>Animal diseases</topic><topic>Animal feeding and feeds</topic><topic>Animal models</topic><topic>Animals</topic><topic>Atrophy</topic><topic>Body weight</topic><topic>Cholesterol</topic><topic>Cholesterol, LDL - blood</topic><topic>Damage assessment</topic><topic>Dextrose</topic><topic>Diabetes mellitus</topic><topic>Diet</topic><topic>Diet, High-Fat</topic><topic>Disease control</topic><topic>Disease Models, Animal</topic><topic>Enriched foods</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Fibrosis</topic><topic>Food</topic><topic>Glucose</topic><topic>Glucose tolerance</topic><topic>Health Promotion and Disease Prevention</topic><topic>High fat diet</topic><topic>Histology</topic><topic>Hogs</topic><topic>Hyperfiltration</topic><topic>Hypertension</topic><topic>Insulin</topic><topic>Insulin Resistance</topic><topic>Internal Medicine</topic><topic>Kidney - pathology</topic><topic>Kidney - physiopathology</topic><topic>Kidney diseases</topic><topic>Kidney Diseases - etiology</topic><topic>Kidney Diseases - pathology</topic><topic>Kidney Diseases - physiopathology</topic><topic>Lipids</topic><topic>Low density lipoprotein</topic><topic>Low density lipoproteins</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Medicine, Experimental</topic><topic>Metabolic Diseases</topic><topic>Metabolic disorders</topic><topic>Metabolic syndrome</topic><topic>Metabolic Syndrome - complications</topic><topic>Obesity</topic><topic>Obesity - complications</topic><topic>Overweight</topic><topic>Pathogenesis</topic><topic>Public Health</topic><topic>Renal function</topic><topic>Swine</topic><topic>Thickening</topic><topic>Trans fatty acids</topic><topic>Triglycerides</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rodríguez, Rosa Rodríguez</creatorcontrib><creatorcontrib>González-Bulnes, Antonio</creatorcontrib><creatorcontrib>Garcia-Contreras, Consolacion</creatorcontrib><creatorcontrib>Elena Rodriguez-Rodriguez, Ana</creatorcontrib><creatorcontrib>Astiz, Susana</creatorcontrib><creatorcontrib>Vazquez-Gomez, Marta</creatorcontrib><creatorcontrib>Luis Pesantez, Jose</creatorcontrib><creatorcontrib>Isabel, Beatriz</creatorcontrib><creatorcontrib>Salido-Ruiz, Eduardo</creatorcontrib><creatorcontrib>González, Jorge</creatorcontrib><creatorcontrib>Donate Correa, Javier</creatorcontrib><creatorcontrib>Luis-Lima, Sergio</creatorcontrib><creatorcontrib>Porrini, Esteban</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Biological Science Database</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>International Journal of Obesity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rodríguez, Rosa Rodríguez</au><au>González-Bulnes, Antonio</au><au>Garcia-Contreras, Consolacion</au><au>Elena Rodriguez-Rodriguez, Ana</au><au>Astiz, Susana</au><au>Vazquez-Gomez, Marta</au><au>Luis Pesantez, Jose</au><au>Isabel, Beatriz</au><au>Salido-Ruiz, Eduardo</au><au>González, Jorge</au><au>Donate Correa, Javier</au><au>Luis-Lima, Sergio</au><au>Porrini, Esteban</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Iberian pig fed with high-fat diet: a model of renal disease in obesity and metabolic syndrome</atitle><jtitle>International Journal of Obesity</jtitle><stitle>Int J Obes</stitle><addtitle>Int J Obes (Lond)</addtitle><date>2020-02-01</date><risdate>2020</risdate><volume>44</volume><issue>2</issue><spage>457</spage><epage>465</epage><pages>457-465</pages><issn>0307-0565</issn><eissn>1476-5497</eissn><abstract>Background
The pathogenesis of renal disease in the context of overweight/obesity, metabolic syndrome, and insulin resistance is not completely understood. This may be due to the lack of a definitive animal model of disease, which limits our understanding of obesity-induced renal damage. We evaluated the changes in renal histology and lipid deposits induced by obesity in a model of insulin resistance: the Iberian swine fed with fat-enriched food.
Methods
Twenty-eight female sows were randomized to standard (SD) or high-fat diet (HFD: 6.8% of saturated fat) for 100 days. Weight, adiposity, analytics, oral glucose tolerance tests, and measured renal function were determined. Renal histology and lipid deposits in renal tissue were analyzed.
Results
Animals on HFD developed obesity, hypertension, high levels of LDL cholesterol, triglycerides, insulin resistance, and glomerular hyperfiltration. No animal developed overt diabetes. Animals on HFD showed “diabetoid changes”, including mesangial expansion [21.40% ± 4 vs.13.20% ± 4.0,
p
< 0.0001], nodular glomerulosclerosis [7.40% ± 7, 0.75 vs. 2.40% ± 4.7,
p
= 0.02], and glomerulomegaly (18% vs. 10%,
p
= 0.010) than those on SD. Tubular atrophy, interstitial fibrosis, inflammation, arteriolar hyalinosis, or fibrointimal thickening were mild and similar between groups. Triglyceride content in renal tissue was higher in animals on HFD than in SD (15.4% ± 0.5 vs. 12.7% ± 0.7;
p
< 0.01).
Conclusions
Iberian pigs fed with fat-enriched food showed diabetoid changes and glomerulomegaly as observed in obese humans making this model suitable to study obesity-induced renal disease.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>31636376</pmid><doi>10.1038/s41366-019-0434-9</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0307-0565 |
| ispartof | International Journal of Obesity, 2020-02, Vol.44 (2), p.457-465 |
| issn | 0307-0565 1476-5497 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2307735912 |
| source | MEDLINE; Springer Nature - Complete Springer Journals; Nature Journals Online |
| subjects | 101/58 692/163/2743/2037 692/163/2743/393 82/16 96/63 Adipose tissue Analysis Animal diseases Animal feeding and feeds Animal models Animals Atrophy Body weight Cholesterol Cholesterol, LDL - blood Damage assessment Dextrose Diabetes mellitus Diet Diet, High-Fat Disease control Disease Models, Animal Enriched foods Epidemiology Female Fibrosis Food Glucose Glucose tolerance Health Promotion and Disease Prevention High fat diet Histology Hogs Hyperfiltration Hypertension Insulin Insulin Resistance Internal Medicine Kidney - pathology Kidney - physiopathology Kidney diseases Kidney Diseases - etiology Kidney Diseases - pathology Kidney Diseases - physiopathology Lipids Low density lipoprotein Low density lipoproteins Medical research Medicine Medicine & Public Health Medicine, Experimental Metabolic Diseases Metabolic disorders Metabolic syndrome Metabolic Syndrome - complications Obesity Obesity - complications Overweight Pathogenesis Public Health Renal function Swine Thickening Trans fatty acids Triglycerides Triglycerides - blood |
| title | The Iberian pig fed with high-fat diet: a model of renal disease in obesity and metabolic syndrome |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-18T23%3A09%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Iberian%20pig%20fed%20with%20high-fat%20diet:%20a%20model%20of%20renal%20disease%20in%20obesity%20and%20metabolic%20syndrome&rft.jtitle=International%20Journal%20of%20Obesity&rft.au=Rodr%C3%ADguez,%20Rosa%20Rodr%C3%ADguez&rft.date=2020-02-01&rft.volume=44&rft.issue=2&rft.spage=457&rft.epage=465&rft.pages=457-465&rft.issn=0307-0565&rft.eissn=1476-5497&rft_id=info:doi/10.1038/s41366-019-0434-9&rft_dat=%3Cgale_proqu%3EA613154024%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2350323557&rft_id=info:pmid/31636376&rft_galeid=A613154024&rfr_iscdi=true |