Aerobic Oxidative Sulfenylation of Pyrazolones and Pyrazoles Catalyzed by Metal-Free Flavin–Iodine Catalysis

Two-component metal-free catalytic oxidative sulfenylation of pyrazolones with thiols has been achieved using the biomimetic flavin and iodine. The methodology is mild and eco-friendly, proceeds in the presence of air or molecular oxygen (1 atm) as the sole sacrificial reagent, and generates water a...

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Veröffentlicht in:	Journal of organic chemistry 2019-11, Vol.84 (22), p.14980-14986
Hauptverfasser:	Tanimoto, Kazumasa, Ohkado, Ryoma, Iida, Hiroki
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Sprache:	eng
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container_title	Journal of organic chemistry
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creator	Tanimoto, Kazumasa Ohkado, Ryoma Iida, Hiroki
description	Two-component metal-free catalytic oxidative sulfenylation of pyrazolones with thiols has been achieved using the biomimetic flavin and iodine. The methodology is mild and eco-friendly, proceeds in the presence of air or molecular oxygen (1 atm) as the sole sacrificial reagent, and generates water as the only byproduct. The methodology was also extended to the sulfenylation of pyrazoles and electron-rich benzenes and afforded a series of thioethers in good yields.
doi_str_mv	10.1021/acs.joc.9b02422
format	Article
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title	Aerobic Oxidative Sulfenylation of Pyrazolones and Pyrazoles Catalyzed by Metal-Free Flavin–Iodine Catalysis
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