Quantification of Proteins and Histone Marks in Drosophila Embryos Reveals Stoichiometric Relationships Impacting Chromatin Regulation

Gene transcription in eukaryotes is regulated through dynamic interactions of a variety of different proteins with DNA in the context of chromatin. Here, we used mass spectrometry for absolute quantification of the nuclear proteome and methyl marks on selected lysine residues in histone H3 during tw...

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Veröffentlicht in:	Developmental cell 2019-12, Vol.51 (5), p.632-644.e6
Hauptverfasser:	Bonnet, Jacques, Lindeboom, Rik G.H., Pokrovsky, Daniil, Stricker, Georg, Çelik, Muhammed Hasan, Rupp, Ralph A.W., Gagneur, Julien, Vermeulen, Michiel, Imhof, Axel, Müller, Jürg
Format:	Artikel
Sprache:	eng
Schlagworte:	absolute proteome quantification Drosophila H3K27 methylation histone modification quantification PRC2
Online-Zugang:	Volltext
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