Epimerization-Free Preparation of C‑Terminal Cys Peptide Acid by Fmoc SPPS Using Pseudoproline-Type Protecting Group

Preparation of C-terminal Cys-containing peptide acid by Fmoc solid-phase peptide synthesis (SPPS) is difficult due to base-mediated epimerization at Cys. In this paper, use of a C-terminal pseudoproline structure and Trt­(2-Cl) resin achieved epimerization-free direct preparation of the C-terminal...

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Veröffentlicht in:	Journal of organic chemistry 2020-02, Vol.85 (3), p.1674-1679
Hauptverfasser:	Tsuda, Shugo, Masuda, Shun, Yoshiya, Taku
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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