Free Radical Addition of Nitrile, Ketone, and Ester to Alkyne and the Selectivity Discussion
A general and practical atom transfer radical addition (ATRA) of simple nitriles, ketones, and esters to alkynes was developed. It can allow an efficient access to a wide range of β,γ-unsaturated nitriles, ketones, and esters. The unique chemoselectivity in this system is also discussed.
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| Veröffentlicht in: | Organic letters 2019-11, Vol.21 (21), p.8810-8813 |
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| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | A general and practical atom transfer radical addition (ATRA) of simple nitriles, ketones, and esters to alkynes was developed. It can allow an efficient access to a wide range of β,γ-unsaturated nitriles, ketones, and esters. The unique chemoselectivity in this system is also discussed. |
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| ISSN: | 1523-7060 1523-7052 |
| DOI: | 10.1021/acs.orglett.9b03444 |