The pathogenic role of autoantibodies in recurrent pregnancy loss
In the present manuscript, we review the recent research investigating the pathogenic association between most studied autoantibodies and recurrent pregnancy loss. Pregnancy loss represents a common obstetric complication occurring in about 15%‐25% of all clinically recognized pregnancies. The recur...
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| Veröffentlicht in: | American journal of reproductive immunology (1989) 2020-01, Vol.83 (1), p.e13200-n/a |
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| container_title | American journal of reproductive immunology (1989) |
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| creator | D'Ippolito, Silvia Ticconi, Carlo Tersigni, Chiara Garofalo, Serafina Martino, Carmelinda Lanzone, Antonio Scambia, Giovanni Di Simone, Nicoletta |
| description | In the present manuscript, we review the recent research investigating the pathogenic association between most studied autoantibodies and recurrent pregnancy loss. Pregnancy loss represents a common obstetric complication occurring in about 15%‐25% of all clinically recognized pregnancies. The recurrence of pregnancy loss identifies a distinct clinical entity, that is recurrent pregnancy loss (RPL), affecting about 2%‐4% of couples. Several factors, including age, chromosomal abnormalities, uterine anomalies, thrombophilic disorders, endocrinopathies, hormonal and metabolic disorders, infections, sperm quality, and lifestyle issues, are involved in RPL. The role of autoantibodies in RPL is only partially determined. In some cases (antiphospholipid antibodies [aPL]), their involvement is well established. In other cases (anti‐thyroid autoantibodies, antinuclear, anti‐transglutaminase, and anti‐endomysial antibodies), it is still debated, despite multiple, although not fully conclusive, evidences strongly suggest a possible involvement in RPL. Further extensive research is needed to definitively confirm or exclude their actual role. |
| doi_str_mv | 10.1111/aji.13200 |
| format | Article |
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Pregnancy loss represents a common obstetric complication occurring in about 15%‐25% of all clinically recognized pregnancies. The recurrence of pregnancy loss identifies a distinct clinical entity, that is recurrent pregnancy loss (RPL), affecting about 2%‐4% of couples. Several factors, including age, chromosomal abnormalities, uterine anomalies, thrombophilic disorders, endocrinopathies, hormonal and metabolic disorders, infections, sperm quality, and lifestyle issues, are involved in RPL. The role of autoantibodies in RPL is only partially determined. In some cases (antiphospholipid antibodies [aPL]), their involvement is well established. In other cases (anti‐thyroid autoantibodies, antinuclear, anti‐transglutaminase, and anti‐endomysial antibodies), it is still debated, despite multiple, although not fully conclusive, evidences strongly suggest a possible involvement in RPL. Further extensive research is needed to definitively confirm or exclude their actual role.</description><identifier>ISSN: 1046-7408</identifier><identifier>EISSN: 1600-0897</identifier><identifier>DOI: 10.1111/aji.13200</identifier><identifier>PMID: 31633847</identifier><language>eng</language><publisher>Denmark: Wiley Subscription Services, Inc</publisher><subject>antinuclear antibodies ; Antiphospholipid antibodies ; anti‐thyroid antibodies ; Autoantibodies ; celiac disease ; Endocrine disorders ; Metabolic disorders ; Miscarriage ; Pregnancy ; recurrent pregnancy loss ; Risk factors ; Thyroid ; Uterus</subject><ispartof>American journal of reproductive immunology (1989), 2020-01, Vol.83 (1), p.e13200-n/a</ispartof><rights>2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2020 John Wiley & Sons A/S. 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Pregnancy loss represents a common obstetric complication occurring in about 15%‐25% of all clinically recognized pregnancies. The recurrence of pregnancy loss identifies a distinct clinical entity, that is recurrent pregnancy loss (RPL), affecting about 2%‐4% of couples. Several factors, including age, chromosomal abnormalities, uterine anomalies, thrombophilic disorders, endocrinopathies, hormonal and metabolic disorders, infections, sperm quality, and lifestyle issues, are involved in RPL. The role of autoantibodies in RPL is only partially determined. In some cases (antiphospholipid antibodies [aPL]), their involvement is well established. In other cases (anti‐thyroid autoantibodies, antinuclear, anti‐transglutaminase, and anti‐endomysial antibodies), it is still debated, despite multiple, although not fully conclusive, evidences strongly suggest a possible involvement in RPL. 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Pregnancy loss represents a common obstetric complication occurring in about 15%‐25% of all clinically recognized pregnancies. The recurrence of pregnancy loss identifies a distinct clinical entity, that is recurrent pregnancy loss (RPL), affecting about 2%‐4% of couples. Several factors, including age, chromosomal abnormalities, uterine anomalies, thrombophilic disorders, endocrinopathies, hormonal and metabolic disorders, infections, sperm quality, and lifestyle issues, are involved in RPL. The role of autoantibodies in RPL is only partially determined. In some cases (antiphospholipid antibodies [aPL]), their involvement is well established. In other cases (anti‐thyroid autoantibodies, antinuclear, anti‐transglutaminase, and anti‐endomysial antibodies), it is still debated, despite multiple, although not fully conclusive, evidences strongly suggest a possible involvement in RPL. 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| subjects | antinuclear antibodies Antiphospholipid antibodies anti‐thyroid antibodies Autoantibodies celiac disease Endocrine disorders Metabolic disorders Miscarriage Pregnancy recurrent pregnancy loss Risk factors Thyroid Uterus |
| title | The pathogenic role of autoantibodies in recurrent pregnancy loss |
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