Neural correlates of prospection impairments in schizophrenia: Evidence from voxel-based morphometry analysis
•To examine the structural neural correlates of prospection impairments and the involvement of working memory in prospection in schizophrenia patients.•GM loss in the prefrontal cortex is associated with prospection impairments in schizophrenia patients.•Working memory deficits may partially account...
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| Veröffentlicht in: | Psychiatry research. Neuroimaging 2019-11, Vol.293, p.110987-110987, Article 110987 |
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| container_title | Psychiatry research. Neuroimaging |
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| creator | Yang, Zhuo-ya Wang, Shuang-kun Li, Ying Wang, Yi Wang, Yong-ming Zhou, Han-yu Cai, Xin-lu Cheung, Eric F.C. Shum, David H.K. Öngür, Dost Chan, Raymond C.K. |
| description | •To examine the structural neural correlates of prospection impairments and the involvement of working memory in prospection in schizophrenia patients.•GM loss in the prefrontal cortex is associated with prospection impairments in schizophrenia patients.•Working memory deficits may partially account for prospection impairments in schizophrenia patients.
Prospection, which has a close relationship with motivation and goal-directed behavior, could be a potential target for alleviating negative symptoms. The present study aimed to examine the structural neural correlates of prospection impairments and the involvement of working memory in prospection in schizophrenia patients. Thirty-seven patients with schizophrenia and 28 healthy controls were recruited and all of them completed a prospection task. Working memory was assessed with the Letter Number Span test. In addition, all participants underwent a structural MRI scan. Voxel-based morphometry (VBM) analysis was used to measure grey matter (GM) volume. We found that in schizophrenia patients, GM loss in the right lateral prefrontal cortex (PFC) and the right ventral medial PFC was correlated with decreased internal details in the prospection task. Moreover, GM volume of the right lateral PFC was found to mediate the relationship between working memory and internal details in these patients. In conclusion, GM loss in the PFC is associated with prospection impairments in schizophrenia patients. Working memory deficits may partially account for prospection impairments in schizophrenia patients. |
| doi_str_mv | 10.1016/j.pscychresns.2019.110987 |
| format | Article |
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Prospection, which has a close relationship with motivation and goal-directed behavior, could be a potential target for alleviating negative symptoms. The present study aimed to examine the structural neural correlates of prospection impairments and the involvement of working memory in prospection in schizophrenia patients. Thirty-seven patients with schizophrenia and 28 healthy controls were recruited and all of them completed a prospection task. Working memory was assessed with the Letter Number Span test. In addition, all participants underwent a structural MRI scan. Voxel-based morphometry (VBM) analysis was used to measure grey matter (GM) volume. We found that in schizophrenia patients, GM loss in the right lateral prefrontal cortex (PFC) and the right ventral medial PFC was correlated with decreased internal details in the prospection task. Moreover, GM volume of the right lateral PFC was found to mediate the relationship between working memory and internal details in these patients. In conclusion, GM loss in the PFC is associated with prospection impairments in schizophrenia patients. Working memory deficits may partially account for prospection impairments in schizophrenia patients.</description><identifier>ISSN: 0925-4927</identifier><identifier>EISSN: 1872-7506</identifier><identifier>DOI: 10.1016/j.pscychresns.2019.110987</identifier><identifier>PMID: 31629132</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Female ; Gray Matter - diagnostic imaging ; Gray Matter - physiopathology ; Humans ; Magnetic Resonance Imaging ; Male ; Memory Disorders - diagnostic imaging ; Memory Disorders - physiopathology ; Memory, Short-Term - physiology ; Prefrontal Cortex - diagnostic imaging ; Prefrontal Cortex - physiopathology ; Prospection ; Schizophrenia ; Schizophrenia - diagnostic imaging ; Schizophrenia - physiopathology ; Voxel-based morphometry ; Working memory</subject><ispartof>Psychiatry research. Neuroimaging, 2019-11, Vol.293, p.110987-110987, Article 110987</ispartof><rights>2019 Elsevier B.V.</rights><rights>Copyright © 2019 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-5dfbe33db589dee6d6ad24cb9c044dfd63a8b18580888b7f62c77e3023d4b9343</citedby><cites>FETCH-LOGICAL-c428t-5dfbe33db589dee6d6ad24cb9c044dfd63a8b18580888b7f62c77e3023d4b9343</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.pscychresns.2019.110987$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27928,27929,45999</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31629132$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Zhuo-ya</creatorcontrib><creatorcontrib>Wang, Shuang-kun</creatorcontrib><creatorcontrib>Li, Ying</creatorcontrib><creatorcontrib>Wang, Yi</creatorcontrib><creatorcontrib>Wang, Yong-ming</creatorcontrib><creatorcontrib>Zhou, Han-yu</creatorcontrib><creatorcontrib>Cai, Xin-lu</creatorcontrib><creatorcontrib>Cheung, Eric F.C.</creatorcontrib><creatorcontrib>Shum, David H.K.</creatorcontrib><creatorcontrib>Öngür, Dost</creatorcontrib><creatorcontrib>Chan, Raymond C.K.</creatorcontrib><title>Neural correlates of prospection impairments in schizophrenia: Evidence from voxel-based morphometry analysis</title><title>Psychiatry research. Neuroimaging</title><addtitle>Psychiatry Res Neuroimaging</addtitle><description>•To examine the structural neural correlates of prospection impairments and the involvement of working memory in prospection in schizophrenia patients.•GM loss in the prefrontal cortex is associated with prospection impairments in schizophrenia patients.•Working memory deficits may partially account for prospection impairments in schizophrenia patients.
Prospection, which has a close relationship with motivation and goal-directed behavior, could be a potential target for alleviating negative symptoms. The present study aimed to examine the structural neural correlates of prospection impairments and the involvement of working memory in prospection in schizophrenia patients. Thirty-seven patients with schizophrenia and 28 healthy controls were recruited and all of them completed a prospection task. Working memory was assessed with the Letter Number Span test. In addition, all participants underwent a structural MRI scan. Voxel-based morphometry (VBM) analysis was used to measure grey matter (GM) volume. We found that in schizophrenia patients, GM loss in the right lateral prefrontal cortex (PFC) and the right ventral medial PFC was correlated with decreased internal details in the prospection task. Moreover, GM volume of the right lateral PFC was found to mediate the relationship between working memory and internal details in these patients. In conclusion, GM loss in the PFC is associated with prospection impairments in schizophrenia patients. Working memory deficits may partially account for prospection impairments in schizophrenia patients.</description><subject>Female</subject><subject>Gray Matter - diagnostic imaging</subject><subject>Gray Matter - physiopathology</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Memory Disorders - diagnostic imaging</subject><subject>Memory Disorders - physiopathology</subject><subject>Memory, Short-Term - physiology</subject><subject>Prefrontal Cortex - diagnostic imaging</subject><subject>Prefrontal Cortex - physiopathology</subject><subject>Prospection</subject><subject>Schizophrenia</subject><subject>Schizophrenia - diagnostic imaging</subject><subject>Schizophrenia - physiopathology</subject><subject>Voxel-based morphometry</subject><subject>Working memory</subject><issn>0925-4927</issn><issn>1872-7506</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMtu2zAQRYmgQeyk_YWC3XUjhw89yO4KI2kKGMkmWRMUOYJpiKLKkY06Xx8ZTosuu5rNuXNxDyFfOFtxxuvb3WpEd3TbDDjgSjCuV5wzrZoLsuSqEUVTsfoDWTItqqLUolmQa8QdY0KqWl6RheS10FyKJYmPsM-2py7lDL2dAGnq6JgTjuCmkAYa4mhDjjBMSMNA0W3Daxrn7iHYb_TuEDwMDmiXU6SH9Bv6orUInsaUx22KMOUjtYPtjxjwI7nsbI_w6f3ekJf7u-f1Q7F5-vFz_X1TuFKoqah814KUvq2U9gC1r60XpWu1Y2XpO19Lq1quKsWUUm3T1cI1Dch5ni9bLUt5Q76e_85Dfu0BJxMDOuh7O0DaoxGSNbzUWpxQfUbdvBkzdGbMIdp8NJyZk22zM__YNifb5mx7zn5-r9m3Efzf5B-9M7A-AzCPPQTIBl046fIhz3qNT-E_at4A1qCaaQ</recordid><startdate>20191130</startdate><enddate>20191130</enddate><creator>Yang, Zhuo-ya</creator><creator>Wang, Shuang-kun</creator><creator>Li, Ying</creator><creator>Wang, Yi</creator><creator>Wang, Yong-ming</creator><creator>Zhou, Han-yu</creator><creator>Cai, Xin-lu</creator><creator>Cheung, Eric F.C.</creator><creator>Shum, David H.K.</creator><creator>Öngür, Dost</creator><creator>Chan, Raymond C.K.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20191130</creationdate><title>Neural correlates of prospection impairments in schizophrenia: Evidence from voxel-based morphometry analysis</title><author>Yang, Zhuo-ya ; Wang, Shuang-kun ; Li, Ying ; Wang, Yi ; Wang, Yong-ming ; Zhou, Han-yu ; Cai, Xin-lu ; Cheung, Eric F.C. ; Shum, David H.K. ; Öngür, Dost ; Chan, Raymond C.K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-5dfbe33db589dee6d6ad24cb9c044dfd63a8b18580888b7f62c77e3023d4b9343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Female</topic><topic>Gray Matter - diagnostic imaging</topic><topic>Gray Matter - physiopathology</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Memory Disorders - diagnostic imaging</topic><topic>Memory Disorders - physiopathology</topic><topic>Memory, Short-Term - physiology</topic><topic>Prefrontal Cortex - diagnostic imaging</topic><topic>Prefrontal Cortex - physiopathology</topic><topic>Prospection</topic><topic>Schizophrenia</topic><topic>Schizophrenia - diagnostic imaging</topic><topic>Schizophrenia - physiopathology</topic><topic>Voxel-based morphometry</topic><topic>Working memory</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Zhuo-ya</creatorcontrib><creatorcontrib>Wang, Shuang-kun</creatorcontrib><creatorcontrib>Li, Ying</creatorcontrib><creatorcontrib>Wang, Yi</creatorcontrib><creatorcontrib>Wang, Yong-ming</creatorcontrib><creatorcontrib>Zhou, Han-yu</creatorcontrib><creatorcontrib>Cai, Xin-lu</creatorcontrib><creatorcontrib>Cheung, Eric F.C.</creatorcontrib><creatorcontrib>Shum, David H.K.</creatorcontrib><creatorcontrib>Öngür, Dost</creatorcontrib><creatorcontrib>Chan, Raymond C.K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Psychiatry research. Neuroimaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Zhuo-ya</au><au>Wang, Shuang-kun</au><au>Li, Ying</au><au>Wang, Yi</au><au>Wang, Yong-ming</au><au>Zhou, Han-yu</au><au>Cai, Xin-lu</au><au>Cheung, Eric F.C.</au><au>Shum, David H.K.</au><au>Öngür, Dost</au><au>Chan, Raymond C.K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neural correlates of prospection impairments in schizophrenia: Evidence from voxel-based morphometry analysis</atitle><jtitle>Psychiatry research. Neuroimaging</jtitle><addtitle>Psychiatry Res Neuroimaging</addtitle><date>2019-11-30</date><risdate>2019</risdate><volume>293</volume><spage>110987</spage><epage>110987</epage><pages>110987-110987</pages><artnum>110987</artnum><issn>0925-4927</issn><eissn>1872-7506</eissn><abstract>•To examine the structural neural correlates of prospection impairments and the involvement of working memory in prospection in schizophrenia patients.•GM loss in the prefrontal cortex is associated with prospection impairments in schizophrenia patients.•Working memory deficits may partially account for prospection impairments in schizophrenia patients.
Prospection, which has a close relationship with motivation and goal-directed behavior, could be a potential target for alleviating negative symptoms. The present study aimed to examine the structural neural correlates of prospection impairments and the involvement of working memory in prospection in schizophrenia patients. Thirty-seven patients with schizophrenia and 28 healthy controls were recruited and all of them completed a prospection task. Working memory was assessed with the Letter Number Span test. In addition, all participants underwent a structural MRI scan. Voxel-based morphometry (VBM) analysis was used to measure grey matter (GM) volume. We found that in schizophrenia patients, GM loss in the right lateral prefrontal cortex (PFC) and the right ventral medial PFC was correlated with decreased internal details in the prospection task. Moreover, GM volume of the right lateral PFC was found to mediate the relationship between working memory and internal details in these patients. In conclusion, GM loss in the PFC is associated with prospection impairments in schizophrenia patients. Working memory deficits may partially account for prospection impairments in schizophrenia patients.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>31629132</pmid><doi>10.1016/j.pscychresns.2019.110987</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Female Gray Matter - diagnostic imaging Gray Matter - physiopathology Humans Magnetic Resonance Imaging Male Memory Disorders - diagnostic imaging Memory Disorders - physiopathology Memory, Short-Term - physiology Prefrontal Cortex - diagnostic imaging Prefrontal Cortex - physiopathology Prospection Schizophrenia Schizophrenia - diagnostic imaging Schizophrenia - physiopathology Voxel-based morphometry Working memory |
| title | Neural correlates of prospection impairments in schizophrenia: Evidence from voxel-based morphometry analysis |
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