Architecture of African swine fever virus and implications for viral assembly

African swine fever virus (ASFV) is a giant and complex DNA virus that causes a highly contagious and often lethal swine disease for which no vaccine is available. Using an optimized image reconstruction strategy, we solved the ASFV capsid structure up to 4.1 angstroms, which is built from 17,280 pr...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2019-11, Vol.366 (6465), p.640-644
Hauptverfasser:	Wang, Nan, Zhao, Dongming, Wang, Jialing, Zhang, Yangling, Wang, Ming, Gao, Yan, Li, Fang, Wang, Jingfei, Bu, Zhigao, Rao, Zihe, Wang, Xiangxi
Format:	Artikel
Sprache:	eng
Schlagworte:	African swine fever African Swine Fever Virus - chemistry African Swine Fever Virus - physiology African Swine Fever Virus - ultrastructure Animals Asfarviridae Capsid - physiology Capsid - ultrastructure Capsid Proteins - chemistry Capsid Proteins - immunology Capsid Proteins - ultrastructure Cells, Cultured Cryoelectron Microscopy Deoxyribonucleic acid DNA Epitopes Livestock Models, Molecular Protein Conformation Protein Domains Protein Folding Protein Structure, Secondary Proteins Swine Vaccine development Virion - chemistry Virion - ultrastructure Virus Assembly Viruses
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