MicroRNA-219a-5p suppresses intestinal inflammation through inhibiting Th1/Th17-mediated immune responses in inflammatory bowel disease

MicroRNA (miR)-219a-5p has been implicated in the development of numerous progression of carcinoma and autoimmune diseases. However, whether miR-219a-5p is involved in the pathogenesis of inflammatory bowel disease (IBD) remains elusive. In this study, we demonstrated that miR-219a-5p expression was...

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Veröffentlicht in:	Mucosal immunology 2020-03, Vol.13 (2), p.303-312
Hauptverfasser:	Shi, Yan, Dai, Shenglan, Qiu, Caiyu, Wang, Tao, Zhou, Yong, Xue, Cuihua, Yao, Jun, Xu, Yaping
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Allergology Animals Antibodies Autoimmune diseases Biomedical and Life Sciences Biomedicine CD4 antigen Cell differentiation Cells, Cultured Colitis - genetics Colitis - immunology Colon Disease Models, Animal DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Female Gastroenterology Gene Expression Regulation Helper cells Humans Immunology Inflammation Inflammatory bowel disease Inflammatory bowel diseases Inflammatory Bowel Diseases - genetics Inflammatory Bowel Diseases - immunology Interleukin 12 Interleukin 23 Interleukin 6 Intestine Lamina propria Lymphocytes Lymphocytes T Male Mice Mice, Inbred BALB C MicroRNAs MicroRNAs - genetics Middle Aged miRNA Mucosa Peripheral blood Phosphorylation Stat3 protein Stat4 protein Supplements Th1 Cells - immunology Th17 Cells - immunology Transcription Factors - genetics Transcription Factors - metabolism Trinitrobenzenesulfonic Acid Tumor necrosis factor-α γ-Interferon
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