Effective mRNA pulmonary delivery by dry powder formulation of PEGylated synthetic KL4 peptide

[Display omitted] •PEG12KL4 peptide is a promising mRNA delivery vector for pulmonary delivery.•Inhalable mRNA dry powder can be prepared by spray drying and spray freeze drying.•PEG12KL4/mRNA formulations did not cause significant toxicity and inflammatory response. Pulmonary delivery of messenger...

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Veröffentlicht in:	Journal of controlled release 2019-11, Vol.314, p.102-115
Hauptverfasser:	Qiu, Yingshan, Man, Rico C.H., Liao, Qiuying, Kung, Keshia L.K., Chow, Michael Y.T., Lam, Jenny K.W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Inhalation mRNA transfection PEGylation Peptide Spray drying Spray freeze drying
Online-Zugang:	Volltext
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