Terpinen-4-ol inhibits the growth of Sporothrix schenckii complex and exhibits synergism with antifungal agents
This study investigated the effect of terpinen-4-ol against complex and its interactions with antifungals. The antifungal activity of terpinen-4-ol was evaluated by broth microdilution. The potential effect on cellular ergosterol concentration was evaluated by spectrophotometry. The antibiofilm acti...
Gespeichert in:
| Veröffentlicht in: | Future microbiology 2019-09, Vol.14 (14), p.1221-1233 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1233 |
|---|---|
| container_issue | 14 |
| container_start_page | 1221 |
| container_title | Future microbiology |
| container_volume | 14 |
| creator | Brilhante, Raimunda Sn Pereira, Vandbergue S Oliveira, Jonathas S Rodrigues, Anderson M de Camargo, Zoilo P Pereira-Neto, Waldemiro A Nascimento, Nilberto Rf Castelo-Branco, Débora Scm Cordeiro, Rossana A Sidrim, José Jc Rocha, Marcos Fg |
| description | This study investigated the effect of terpinen-4-ol against
complex and its interactions with antifungals.
The antifungal activity of terpinen-4-ol was evaluated by broth microdilution. The potential effect on cellular ergosterol concentration was evaluated by spectrophotometry. The antibiofilm activity was evaluated by violet crystal staining and XTT reduction assay. The potential pharmacological interactions with antifungals were evaluated by the checkerboard assay.
terpinen-4-ol (T-OH) showed minimal inhibitory concentrations ranging from 4 to 32 mg/l decreasing cellular ergosterol content and presented a SMIC ranging from 64 to 1024 mg/l for
spp. The combinations of T-OH with itraconazole or terbinafine were synergistic.
T-OH has antifungal activity against
spp. and acts synergistically with standard antifungals. |
| doi_str_mv | 10.2217/fmb-2019-0146 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2307138563</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2307138563</sourcerecordid><originalsourceid>FETCH-LOGICAL-c321t-2d6a24ff497f36c8aa9fbb583708ab83f60ced6618724fd7d76b8d631231c5483</originalsourceid><addsrcrecordid>eNpdkT1v3SAUhlHVqvkcu1ZIXbKQcgADHqMoX1KkDElnC2O4JrXBAVu5-ff1VW4zZDpneN5XR-dB6AfQc8ZA_fZjSxiFmlAQ8gs6BCUkoTWDrx878AN0VMozpZWGGr6jAw6SVUKwQ5SeXJ5CdJEIkgYcYh_aMBc89w5vcnqde5w8fpxSTnOfwxYX27to_4aAbRqnwW2xiR12232uvEWXN6GM-DWsWRPn4Je4MQM2GxfncoK-eTMUd7qfx-jP9dXT5S25f7i5u7y4J5YzmAnrpGHCe1Erz6XVxtS-bSvNFdWm1dxLal0nJWi1Yp3qlGx1JzkwDrYSmh-js_feKaeXxZW5GUOxbhhMdGkpDeNUAdeV5Cv66xP6nJYc1-tWCphQXHK6UuSdsjmVkp1vphxGk98aoM3ORLOaaHYmmp2Jlf-5b13a0XUf9P_X83_AkITd</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2312473630</pqid></control><display><type>article</type><title>Terpinen-4-ol inhibits the growth of Sporothrix schenckii complex and exhibits synergism with antifungal agents</title><source>MEDLINE</source><source>PubMed Central</source><creator>Brilhante, Raimunda Sn ; Pereira, Vandbergue S ; Oliveira, Jonathas S ; Rodrigues, Anderson M ; de Camargo, Zoilo P ; Pereira-Neto, Waldemiro A ; Nascimento, Nilberto Rf ; Castelo-Branco, Débora Scm ; Cordeiro, Rossana A ; Sidrim, José Jc ; Rocha, Marcos Fg</creator><creatorcontrib>Brilhante, Raimunda Sn ; Pereira, Vandbergue S ; Oliveira, Jonathas S ; Rodrigues, Anderson M ; de Camargo, Zoilo P ; Pereira-Neto, Waldemiro A ; Nascimento, Nilberto Rf ; Castelo-Branco, Débora Scm ; Cordeiro, Rossana A ; Sidrim, José Jc ; Rocha, Marcos Fg</creatorcontrib><description>This study investigated the effect of terpinen-4-ol against
complex and its interactions with antifungals.
The antifungal activity of terpinen-4-ol was evaluated by broth microdilution. The potential effect on cellular ergosterol concentration was evaluated by spectrophotometry. The antibiofilm activity was evaluated by violet crystal staining and XTT reduction assay. The potential pharmacological interactions with antifungals were evaluated by the checkerboard assay.
terpinen-4-ol (T-OH) showed minimal inhibitory concentrations ranging from 4 to 32 mg/l decreasing cellular ergosterol content and presented a SMIC ranging from 64 to 1024 mg/l for
spp. The combinations of T-OH with itraconazole or terbinafine were synergistic.
T-OH has antifungal activity against
spp. and acts synergistically with standard antifungals.</description><identifier>ISSN: 1746-0913</identifier><identifier>EISSN: 1746-0921</identifier><identifier>DOI: 10.2217/fmb-2019-0146</identifier><identifier>PMID: 31625442</identifier><language>eng</language><publisher>England: Future Medicine Ltd</publisher><subject>Antifungal activity ; Antifungal agents ; Antifungal Agents - pharmacology ; Biofilms ; Biofilms - drug effects ; Drug Synergism ; Drugs ; Ergosterol ; Ergosterol - analysis ; Experiments ; Fungi ; Itraconazole ; Laboratories ; Microbial Sensitivity Tests ; Microorganisms ; Natural products ; Oils & fats ; Potassium ; Spectrophotometry ; Sporothrix ; Sporothrix - drug effects ; Sporothrix - growth & development ; Sporothrix schenckii ; Sterols ; Synergism ; Terbinafine ; Terpenes - pharmacology ; Terpinene</subject><ispartof>Future microbiology, 2019-09, Vol.14 (14), p.1221-1233</ispartof><rights>Copyright Future Medicine Ltd Sep 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c321t-2d6a24ff497f36c8aa9fbb583708ab83f60ced6618724fd7d76b8d631231c5483</citedby><cites>FETCH-LOGICAL-c321t-2d6a24ff497f36c8aa9fbb583708ab83f60ced6618724fd7d76b8d631231c5483</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27931,27932</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31625442$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brilhante, Raimunda Sn</creatorcontrib><creatorcontrib>Pereira, Vandbergue S</creatorcontrib><creatorcontrib>Oliveira, Jonathas S</creatorcontrib><creatorcontrib>Rodrigues, Anderson M</creatorcontrib><creatorcontrib>de Camargo, Zoilo P</creatorcontrib><creatorcontrib>Pereira-Neto, Waldemiro A</creatorcontrib><creatorcontrib>Nascimento, Nilberto Rf</creatorcontrib><creatorcontrib>Castelo-Branco, Débora Scm</creatorcontrib><creatorcontrib>Cordeiro, Rossana A</creatorcontrib><creatorcontrib>Sidrim, José Jc</creatorcontrib><creatorcontrib>Rocha, Marcos Fg</creatorcontrib><title>Terpinen-4-ol inhibits the growth of Sporothrix schenckii complex and exhibits synergism with antifungal agents</title><title>Future microbiology</title><addtitle>Future Microbiol</addtitle><description>This study investigated the effect of terpinen-4-ol against
complex and its interactions with antifungals.
The antifungal activity of terpinen-4-ol was evaluated by broth microdilution. The potential effect on cellular ergosterol concentration was evaluated by spectrophotometry. The antibiofilm activity was evaluated by violet crystal staining and XTT reduction assay. The potential pharmacological interactions with antifungals were evaluated by the checkerboard assay.
terpinen-4-ol (T-OH) showed minimal inhibitory concentrations ranging from 4 to 32 mg/l decreasing cellular ergosterol content and presented a SMIC ranging from 64 to 1024 mg/l for
spp. The combinations of T-OH with itraconazole or terbinafine were synergistic.
T-OH has antifungal activity against
spp. and acts synergistically with standard antifungals.</description><subject>Antifungal activity</subject><subject>Antifungal agents</subject><subject>Antifungal Agents - pharmacology</subject><subject>Biofilms</subject><subject>Biofilms - drug effects</subject><subject>Drug Synergism</subject><subject>Drugs</subject><subject>Ergosterol</subject><subject>Ergosterol - analysis</subject><subject>Experiments</subject><subject>Fungi</subject><subject>Itraconazole</subject><subject>Laboratories</subject><subject>Microbial Sensitivity Tests</subject><subject>Microorganisms</subject><subject>Natural products</subject><subject>Oils & fats</subject><subject>Potassium</subject><subject>Spectrophotometry</subject><subject>Sporothrix</subject><subject>Sporothrix - drug effects</subject><subject>Sporothrix - growth & development</subject><subject>Sporothrix schenckii</subject><subject>Sterols</subject><subject>Synergism</subject><subject>Terbinafine</subject><subject>Terpenes - pharmacology</subject><subject>Terpinene</subject><issn>1746-0913</issn><issn>1746-0921</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkT1v3SAUhlHVqvkcu1ZIXbKQcgADHqMoX1KkDElnC2O4JrXBAVu5-ff1VW4zZDpneN5XR-dB6AfQc8ZA_fZjSxiFmlAQ8gs6BCUkoTWDrx878AN0VMozpZWGGr6jAw6SVUKwQ5SeXJ5CdJEIkgYcYh_aMBc89w5vcnqde5w8fpxSTnOfwxYX27to_4aAbRqnwW2xiR12232uvEWXN6GM-DWsWRPn4Je4MQM2GxfncoK-eTMUd7qfx-jP9dXT5S25f7i5u7y4J5YzmAnrpGHCe1Erz6XVxtS-bSvNFdWm1dxLal0nJWi1Yp3qlGx1JzkwDrYSmh-js_feKaeXxZW5GUOxbhhMdGkpDeNUAdeV5Cv66xP6nJYc1-tWCphQXHK6UuSdsjmVkp1vphxGk98aoM3ORLOaaHYmmp2Jlf-5b13a0XUf9P_X83_AkITd</recordid><startdate>20190901</startdate><enddate>20190901</enddate><creator>Brilhante, Raimunda Sn</creator><creator>Pereira, Vandbergue S</creator><creator>Oliveira, Jonathas S</creator><creator>Rodrigues, Anderson M</creator><creator>de Camargo, Zoilo P</creator><creator>Pereira-Neto, Waldemiro A</creator><creator>Nascimento, Nilberto Rf</creator><creator>Castelo-Branco, Débora Scm</creator><creator>Cordeiro, Rossana A</creator><creator>Sidrim, José Jc</creator><creator>Rocha, Marcos Fg</creator><general>Future Medicine Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>EHMNL</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20190901</creationdate><title>Terpinen-4-ol inhibits the growth of Sporothrix schenckii complex and exhibits synergism with antifungal agents</title><author>Brilhante, Raimunda Sn ; Pereira, Vandbergue S ; Oliveira, Jonathas S ; Rodrigues, Anderson M ; de Camargo, Zoilo P ; Pereira-Neto, Waldemiro A ; Nascimento, Nilberto Rf ; Castelo-Branco, Débora Scm ; Cordeiro, Rossana A ; Sidrim, José Jc ; Rocha, Marcos Fg</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c321t-2d6a24ff497f36c8aa9fbb583708ab83f60ced6618724fd7d76b8d631231c5483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Antifungal activity</topic><topic>Antifungal agents</topic><topic>Antifungal Agents - pharmacology</topic><topic>Biofilms</topic><topic>Biofilms - drug effects</topic><topic>Drug Synergism</topic><topic>Drugs</topic><topic>Ergosterol</topic><topic>Ergosterol - analysis</topic><topic>Experiments</topic><topic>Fungi</topic><topic>Itraconazole</topic><topic>Laboratories</topic><topic>Microbial Sensitivity Tests</topic><topic>Microorganisms</topic><topic>Natural products</topic><topic>Oils & fats</topic><topic>Potassium</topic><topic>Spectrophotometry</topic><topic>Sporothrix</topic><topic>Sporothrix - drug effects</topic><topic>Sporothrix - growth & development</topic><topic>Sporothrix schenckii</topic><topic>Sterols</topic><topic>Synergism</topic><topic>Terbinafine</topic><topic>Terpenes - pharmacology</topic><topic>Terpinene</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brilhante, Raimunda Sn</creatorcontrib><creatorcontrib>Pereira, Vandbergue S</creatorcontrib><creatorcontrib>Oliveira, Jonathas S</creatorcontrib><creatorcontrib>Rodrigues, Anderson M</creatorcontrib><creatorcontrib>de Camargo, Zoilo P</creatorcontrib><creatorcontrib>Pereira-Neto, Waldemiro A</creatorcontrib><creatorcontrib>Nascimento, Nilberto Rf</creatorcontrib><creatorcontrib>Castelo-Branco, Débora Scm</creatorcontrib><creatorcontrib>Cordeiro, Rossana A</creatorcontrib><creatorcontrib>Sidrim, José Jc</creatorcontrib><creatorcontrib>Rocha, Marcos Fg</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>UK & Ireland Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Future microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brilhante, Raimunda Sn</au><au>Pereira, Vandbergue S</au><au>Oliveira, Jonathas S</au><au>Rodrigues, Anderson M</au><au>de Camargo, Zoilo P</au><au>Pereira-Neto, Waldemiro A</au><au>Nascimento, Nilberto Rf</au><au>Castelo-Branco, Débora Scm</au><au>Cordeiro, Rossana A</au><au>Sidrim, José Jc</au><au>Rocha, Marcos Fg</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Terpinen-4-ol inhibits the growth of Sporothrix schenckii complex and exhibits synergism with antifungal agents</atitle><jtitle>Future microbiology</jtitle><addtitle>Future Microbiol</addtitle><date>2019-09-01</date><risdate>2019</risdate><volume>14</volume><issue>14</issue><spage>1221</spage><epage>1233</epage><pages>1221-1233</pages><issn>1746-0913</issn><eissn>1746-0921</eissn><abstract>This study investigated the effect of terpinen-4-ol against
complex and its interactions with antifungals.
The antifungal activity of terpinen-4-ol was evaluated by broth microdilution. The potential effect on cellular ergosterol concentration was evaluated by spectrophotometry. The antibiofilm activity was evaluated by violet crystal staining and XTT reduction assay. The potential pharmacological interactions with antifungals were evaluated by the checkerboard assay.
terpinen-4-ol (T-OH) showed minimal inhibitory concentrations ranging from 4 to 32 mg/l decreasing cellular ergosterol content and presented a SMIC ranging from 64 to 1024 mg/l for
spp. The combinations of T-OH with itraconazole or terbinafine were synergistic.
T-OH has antifungal activity against
spp. and acts synergistically with standard antifungals.</abstract><cop>England</cop><pub>Future Medicine Ltd</pub><pmid>31625442</pmid><doi>10.2217/fmb-2019-0146</doi><tpages>13</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1746-0913 |
| ispartof | Future microbiology, 2019-09, Vol.14 (14), p.1221-1233 |
| issn | 1746-0913 1746-0921 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2307138563 |
| source | MEDLINE; PubMed Central |
| subjects | Antifungal activity Antifungal agents Antifungal Agents - pharmacology Biofilms Biofilms - drug effects Drug Synergism Drugs Ergosterol Ergosterol - analysis Experiments Fungi Itraconazole Laboratories Microbial Sensitivity Tests Microorganisms Natural products Oils & fats Potassium Spectrophotometry Sporothrix Sporothrix - drug effects Sporothrix - growth & development Sporothrix schenckii Sterols Synergism Terbinafine Terpenes - pharmacology Terpinene |
| title | Terpinen-4-ol inhibits the growth of Sporothrix schenckii complex and exhibits synergism with antifungal agents |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-04T20%3A52%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Terpinen-4-ol%20inhibits%20the%20growth%20of%20Sporothrix%20schenckii%20complex%20and%20exhibits%20synergism%20with%20antifungal%20agents&rft.jtitle=Future%20microbiology&rft.au=Brilhante,%20Raimunda%20Sn&rft.date=2019-09-01&rft.volume=14&rft.issue=14&rft.spage=1221&rft.epage=1233&rft.pages=1221-1233&rft.issn=1746-0913&rft.eissn=1746-0921&rft_id=info:doi/10.2217/fmb-2019-0146&rft_dat=%3Cproquest_cross%3E2307138563%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2312473630&rft_id=info:pmid/31625442&rfr_iscdi=true |