Chromosome Engineering of Human Colon-Derived Organoids to Develop a Model of Traditional Serrated Adenoma

Traditional serrated adenomas (TSAs) are rare colorectal polyps with unique histologic features. Fusions in R-spondin genes have been found in TSAs, but it is not clear whether these are sufficient for TSA development, due to the lack of a chromosome engineering platform for human tissues. We studie...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2020-02, Vol.158 (3), p.638-651.e8
Hauptverfasser:	Kawasaki, Kenta, Fujii, Masayuki, Sugimoto, Shinya, Ishikawa, Keiko, Matano, Mami, Ohta, Yuki, Toshimitsu, Kohta, Takahashi, Sirirat, Hosoe, Naoki, Sekine, Shigeki, Kanai, Takanori, Sato, Toshiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoma - genetics Adenoma - pathology Animals BMP Signaling Colonic Neoplasms - genetics Colonic Neoplasms - pathology Colorectal Cancer CRISPR-Cas Systems Ectopic Crypt Eukaryotic Initiation Factor-3 - genetics Gene Fusion Genetic Engineering Humans Intercellular Signaling Peptides and Proteins - genetics Intestinal Stem Cells Male Mice Models, Biological Neoplasm Transplantation Organoids - pathology Proto-Oncogene Proteins B-raf - genetics Receptor-Like Protein Tyrosine Phosphatases, Class 2 - genetics Receptors, G-Protein-Coupled - genetics Thrombospondins - genetics Tumor Suppressor Protein p53 - genetics Wnt Signaling Pathway
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