The activity prediction of indole inhibitors against HCV NS5B polymerase

Non‐structural viral protein 5B (NS5B) is a viral protein in hepatitis C virus. Although various inhibitors against NS5B have been found, the activity prediction of similar untested inhibitors is still highly desirable. In this respect, the Tchebichef moments (TMs) calculated from the images of mole...

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Veröffentlicht in:	Chemical biology & drug design 2020-02, Vol.95 (2), p.240-247
Hauptverfasser:	Muhire, Jules, Zhai, Hong Lin, Lu, Shao Hua, Li, Sha Sha, Yin, Bo, Mi, Jia Ying
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral Agents - chemistry Antiviral Agents - pharmacology biological activity prediction model Hepacivirus - drug effects Hepacivirus - enzymology hepatitis C virus Indoles - chemistry Indoles - pharmacology Models, Molecular NS5B polymerase inhibitors Quantitative Structure-Activity Relationship Tchebichef image moments Viral Nonstructural Proteins - antagonists & inhibitors
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