Rheumatoid arthritis induces enteric neurodegeneration and jejunal inflammation, and quercetin promotes neuroprotective and anti-inflammatory actions

The aim of our study was to study the pathological mechanisms induced by the rheumatoid arthritis (RA) on the Enteric Nervous System (ENS). We evaluated the effect of the chronic arthritis and its treatment with 50 mg/kg quercetin alone (AQ) and combined with 17.5 mg/kg ibuprofen (AIQ) for 60 days o...

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Veröffentlicht in:	Life sciences (1973) 2019-12, Vol.238, p.116956-116956, Article 116956
Hauptverfasser:	Piovezana Bossolani, Gleison Daion, Silva, Bruna Thais, Colombo Martins Perles, Juliana Vanessa, Lima, Mariana Machado, Vieira Frez, Flávia Cristina, Garcia de Souza, Sara Raquel, Sehaber-Sierakowski, Camila Caviquioli, Bersani-Amado, Ciomar Aparecida, Zanoni, Jacqueline Nelisis
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - pharmacology Antioxidants Antioxidants - pharmacology Arthritis Arthritis, Experimental - chemically induced Arthritis, Experimental - complications Arthritis, Rheumatoid - complications Atrophy CD20 antigen CD45 antigen Enteric nervous system Enteric Nervous System - drug effects Enteric Nervous System - pathology Glia Glial cell line-derived neurotrophic factor Glial cells Glial fibrillary acidic protein Ibuprofen Inflammation Inflammation - drug therapy Inflammation - etiology Inflammation - pathology Intestine Jejunum Jejunum - drug effects Jejunum - immunology Jejunum - pathology Lymphocytes Male Mucosa Myenteric plexus Nervous system Neurodegeneration Neurodegenerative Diseases - drug therapy Neurodegenerative Diseases - etiology Neurodegenerative Diseases - pathology Neuronal-glial interactions Neurons Neuroprotection Neuroprotection - drug effects Neuroprotective Agents - pharmacology Nonsteroidal anti-inflammatory drugs Occupancy Parameters Quercetin Quercetin - pharmacology Rats Rats, Sprague-Dawley Rheumatoid arthritis
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