Down-regulated long non-coding RNA PVT1 contributes to gestational diabetes mellitus and preeclampsia via regulation of human trophoblast cells

We aimed to explore the expression level and biological function of lncRNA PVT1 in human trophoblast cells. The expression levels of PVT1 in cancer cell lines, HTR8/SVneo cell, HUVEC cell, the maternal placenta of GDM patients, PE patients and normal pregnancy were detected by qRT-PCR. The cell cult...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2019-12, Vol.120, p.109501-109501, Article 109501
Hauptverfasser:	Wang, Qiuhong, Lu, Xun, Li, Chunyan, Zhang, Wen, Lv, Yan, Wang, Luyao, Wu, Lan, Meng, Li, Fan, Yuru, Ding, Hongjuan, Long, Wei, Lv, Mingming
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - physiology Cell Line Cell Line, Tumor Cell Movement Cell Proliferation Diabetes, Gestational - metabolism Down-Regulation Female Gene Knockdown Techniques Gene Silencing Gestational diabetes mellitus Human Umbilical Vein Endothelial Cells Humans lncRNA Pre-Eclampsia - metabolism Preeclampsia Pregnancy PVT1 RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism Trophoblast cells Trophoblasts - metabolism
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