Tolerance regeneration by T regulatory cells in autologous haematopoietic stem cell transplantation for autoimmune diseases
Autologous haematopoietic stem cell transplantation shows increasing promise as a therapeutic option for patients with treatment-refractory autoimmune disease, particularly systemic sclerosis and multiple sclerosis. However, this intensive chemotherapy-based procedure is not always possible due to p...
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| Veröffentlicht in: | Bone marrow transplantation (Basingstoke) 2020-05, Vol.55 (5), p.857-866 |
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| creator | Hendrawan, Kevin Visweswaran, Malini Ma, David D. F. Moore, John J. |
| description | Autologous haematopoietic stem cell transplantation shows increasing promise as a therapeutic option for patients with treatment-refractory autoimmune disease, particularly systemic sclerosis and multiple sclerosis. However, this intensive chemotherapy-based procedure is not always possible due to potential treatment toxicities and comorbidities. The biological mechanisms of how this procedure induces long-term remission in autoimmune disease are increasingly understood. The focus of this review is on recent research findings on the role of CD4+ T regulatory cells (Tregs) in resetting the immune system leading to the eradication of the autoimmune disease after transplantation. Discovery of the precise mechanisms of this process will allow development of novel Treg-based therapies and thus avoid the need for intensive chemotherapy-based treatment for these autoimmune diseases in the future. |
| doi_str_mv | 10.1038/s41409-019-0710-2 |
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F.</creatorcontrib><creatorcontrib>Moore, John J.</creatorcontrib><title>Tolerance regeneration by T regulatory cells in autologous haematopoietic stem cell transplantation for autoimmune diseases</title><title>Bone marrow transplantation (Basingstoke)</title><addtitle>Bone Marrow Transplant</addtitle><addtitle>Bone Marrow Transplant</addtitle><description>Autologous haematopoietic stem cell transplantation shows increasing promise as a therapeutic option for patients with treatment-refractory autoimmune disease, particularly systemic sclerosis and multiple sclerosis. However, this intensive chemotherapy-based procedure is not always possible due to potential treatment toxicities and comorbidities. The biological mechanisms of how this procedure induces long-term remission in autoimmune disease are increasingly understood. The focus of this review is on recent research findings on the role of CD4+ T regulatory cells (Tregs) in resetting the immune system leading to the eradication of the autoimmune disease after transplantation. 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The biological mechanisms of how this procedure induces long-term remission in autoimmune disease are increasingly understood. The focus of this review is on recent research findings on the role of CD4+ T regulatory cells (Tregs) in resetting the immune system leading to the eradication of the autoimmune disease after transplantation. Discovery of the precise mechanisms of this process will allow development of novel Treg-based therapies and thus avoid the need for intensive chemotherapy-based treatment for these autoimmune diseases in the future.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>31619766</pmid><doi>10.1038/s41409-019-0710-2</doi><tpages>10</tpages></addata></record> |
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| ispartof | Bone marrow transplantation (Basingstoke), 2020-05, Vol.55 (5), p.857-866 |
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| source | Springer Nature - Complete Springer Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | 631/250/1854/2813 631/250/1904 Autografts Autoimmune diseases B cells Cancer CD4 antigen Cell Biology Chemotherapy Disease Health aspects Health services Hematology Hematopoietic stem cells Immune system Immunological tolerance Immunoregulation Internal Medicine Lymphocytes T Medical treatment Medicine Medicine & Public Health Multiple sclerosis Public Health Regeneration Remission Review Article Scleroderma Scleroderma (Disease) Stem cell research Stem cell transplantation Stem Cells Systemic scleroderma Systemic sclerosis Therapeutic applications Toxicity Transplantation |
| title | Tolerance regeneration by T regulatory cells in autologous haematopoietic stem cell transplantation for autoimmune diseases |
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