The ADP/ATP translocase drives mitophagy independent of nucleotide exchange

Mitochondrial homeostasis depends on mitophagy, the programmed degradation of mitochondria. Only a few proteins are known to participate in mitophagy. Here we develop a multidimensional CRISPR–Cas9 genetic screen, using multiple mitophagy reporter systems and pro-mitophagy triggers, and identify num...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature (London) 2019-11, Vol.575 (7782), p.375-379
Hauptverfasser:	Hoshino, Atsushi, Wang, Wei-jia, Wada, Shogo, McDermott-Roe, Chris, Evans, Chantell S., Gosis, Bridget, Morley, Michael P., Rathi, Komal S., Li, Jian, Li, Kristina, Yang, Steven, McManus, Meagan J., Bowman, Caitlyn, Potluri, Prasanth, Levin, Michael, Damrauer, Scott, Wallace, Douglas C., Holzbaur, Erika L. F., Arany, Zoltan
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/1 13/106 13/109 13/31 13/44 13/51 13/89 14 14/19 38 38/39 38/47 38/77 38/89 631/337 631/80/304 631/80/39/2348 631/80/642/333 64/60 Ablation Adenine Adenosine diphosphate Adenosine triphosphate ADP/ATP translocase Analysis Animals Autophagy Autophagy (Cytology) Bioenergetics Bioinformatics Cardiomyopathy Catalytic activity Cell Line Collapse Control CRISPR Deoxyribonucleic acid DNA Exchanging Genes Genetic screening Genomes Homeostasis Humanities and Social Sciences Influence Kinases Mice Mitochondria Mitochondrial DNA Mitochondrial Membrane Transport Proteins - genetics Mitochondrial Membrane Transport Proteins - metabolism Mitochondrial Precursor Protein Import Complex Proteins Mitophagy multidisciplinary Mutation Neuroblastoma Nucleotides Nucleotides - metabolism Parkin protein Phosphorylation Protein Binding Protein Kinases - genetics Protein Kinases - metabolism Proteins PTEN-induced putative kinase Science Science (multidisciplinary) Translocase Translocation (Genetics)
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!