Inhibitory Effects of Pectinase‐Treated Prunus Mume Fruit Concentrate on Colorectal Cancer Proliferation and Angiogenesis of Endothelial Cells

Pectinase is a well‐known enzyme used in the food processing industry to produce fruit juice and concentrate. This study evaluated the anticancer and antiangiogenesis activities of pectinase‐treated Prunus mume fruit concentrate (PC) and its phenolic components. PC treatment (250 to 1,000 µg/mL) res...

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Veröffentlicht in:	Journal of food science 2019-11, Vol.84 (11), p.3284-3295
Hauptverfasser:	Cho, Hyun‐Dong, Kim, Jeong‐Ho, Won, Yeong‐Seon, Moon, Kwang‐Deok, Seo, Kwon‐Il
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Angiogenesis Inhibitors - chemistry Angiogenesis Inhibitors - pharmacology Animals Anticancer properties Aorta Apoptosis Apoptosis - drug effects Cancer Capillary tubes Caspase Cell adhesion & migration Cell cycle Cell Line, Tumor Cell migration Cell Movement - drug effects Cell proliferation Cell Proliferation - drug effects Colon Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Colorectal Neoplasms - physiopathology Endothelial cells Enzymes Food processing Food processing industry Fruit - chemistry Fruit juices Fruits Functional foods & nutraceuticals Growth factors High-performance liquid chromatography Human Umbilical Vein Endothelial Cells - cytology Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - metabolism Humans Hydroxybenzoates - chemistry Hydroxybenzoates - pharmacology Liquid chromatography Pectinase phenolic compound Phenolic compounds Phenols Phenols - chemistry Phenols - pharmacology Plant Extracts - chemistry Plant Extracts - pharmacology Poly(ADP-ribose) polymerase Polygalacturonase - chemistry Population decline Processing industry Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism Protocatechuic acid Prunus - chemistry Prunus mume Pulp Rats Shrinkage Toxicity Turbidity Umbilical vein Vascular endothelial growth factor Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism Veins
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