Antibody response to vaccination after haematopoietic cell transplantation in children using a reduced dose schedule—A retrospective cohort study
Children receiving HCT loose protective immunity to vaccines received pre‐HCT. Therefore, revaccination post‐HCT is of major importance. In Denmark, a vaccination schedule with fewer doses post‐HCT has been used, including two doses for diphtheria, tetanus, polio, measles, mumps, and rubella, and on...
Gespeichert in:
Veröffentlicht in: | Pediatric transplantation 2020-02, Vol.24 (1), p.e13599-n/a |
---|---|
Hauptverfasser: | , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | n/a |
---|---|
container_issue | 1 |
container_start_page | e13599 |
container_title | Pediatric transplantation |
container_volume | 24 |
creator | Jensen, Lotte Poulsen, Anja Nygaard, Ulrikka Scheike, Thomas Riis, Margit Schilling Pedersen, Freddy Karup Heilmann, Carsten |
description | Children receiving HCT loose protective immunity to vaccines received pre‐HCT. Therefore, revaccination post‐HCT is of major importance. In Denmark, a vaccination schedule with fewer doses post‐HCT has been used, including two doses for diphtheria, tetanus, polio, measles, mumps, and rubella, and one dose only for Haemophilus influenzae type B. The background for this was the presumption that post‐HCT immunization constituted booster vaccination of donor immunity. Our objective was to evaluate the proportion of children protected after the scheduled vaccination programme. A nationwide retrospective cohort study of all children who have received an HCT in Denmark during 1994‐2012. Antibody levels were analysed in blood samples drawn before and after vaccination, and the probability of achieving protection after the scheduled immunization programme was estimated. A total of 198 children were included. The protection post‐immunization was as follows: diphtheria 75.3%, tetanus 89.1%, polio 97.7%, and Haemophilus influenzae type B 94.8%. For diphtheria and tetanus, the probability of achieving protection increased to 93.8% and 97.3%, respectively, after a third dose. For measles, mumps, and rubella, the probability of achieving protection was 89.4%, 80.9%, and 94.2%, respectively. In conclusion, our findings support a more extensive vaccination schedule including three doses for diphtheria and tetanus which are in line with current international guidelines. |
doi_str_mv | 10.1111/petr.13599 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2306219899</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2344057142</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3169-a352e5f732a753f48e687c3b4c652de1659aec25b4df43663607f5e13caec11e3</originalsourceid><addsrcrecordid>eNp9kctO3DAUhq0KVCjtpg-ALHVTVQq140vGyxHiUgkJhOg68tgnHaOMHWxn0Oz6DvCEfRI8BFh0gTf2sT99Osc_Ql8pOaJl_RwgxyPKhFIf0D5lSlWMcLnzfG4qRnm9hz6ldEsIlXzGP6I9RiVt6obso4e5z24R7AZHSEPwCXAOeK2NcV5nFzzWXYaIlxpWOochOMjOYAN9j3PUPg299nkincdm6XobweMxOf8H62K1owGLbSjmZJal7OHf38d5eckxpAFMdmvAJixDzDjl0W4-o91O9wm-vOwH6Pfpyc3xeXVxefbreH5RmdK_qjQTNYiuYbVuBOv4DOSsMWzBjRS1BSqF0mBqseC240xKJknTCaDMlGtKgR2g75N3iOFuhJTblUvbybSHMKa2ZkTWVM2UKui3_9DbMEZfuisU50Q05ZcL9WOiTJksRejaIbqVjpuWknYbVbuNqn2OqsCHL8pxsQL7hr5mUwA6Afeuh807qvbq5OZ6kj4BAhmi6g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2344057142</pqid></control><display><type>article</type><title>Antibody response to vaccination after haematopoietic cell transplantation in children using a reduced dose schedule—A retrospective cohort study</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Jensen, Lotte ; Poulsen, Anja ; Nygaard, Ulrikka ; Scheike, Thomas ; Riis, Margit Schilling ; Pedersen, Freddy Karup ; Heilmann, Carsten</creator><creatorcontrib>Jensen, Lotte ; Poulsen, Anja ; Nygaard, Ulrikka ; Scheike, Thomas ; Riis, Margit Schilling ; Pedersen, Freddy Karup ; Heilmann, Carsten</creatorcontrib><description>Children receiving HCT loose protective immunity to vaccines received pre‐HCT. Therefore, revaccination post‐HCT is of major importance. In Denmark, a vaccination schedule with fewer doses post‐HCT has been used, including two doses for diphtheria, tetanus, polio, measles, mumps, and rubella, and one dose only for Haemophilus influenzae type B. The background for this was the presumption that post‐HCT immunization constituted booster vaccination of donor immunity. Our objective was to evaluate the proportion of children protected after the scheduled vaccination programme. A nationwide retrospective cohort study of all children who have received an HCT in Denmark during 1994‐2012. Antibody levels were analysed in blood samples drawn before and after vaccination, and the probability of achieving protection after the scheduled immunization programme was estimated. A total of 198 children were included. The protection post‐immunization was as follows: diphtheria 75.3%, tetanus 89.1%, polio 97.7%, and Haemophilus influenzae type B 94.8%. For diphtheria and tetanus, the probability of achieving protection increased to 93.8% and 97.3%, respectively, after a third dose. For measles, mumps, and rubella, the probability of achieving protection was 89.4%, 80.9%, and 94.2%, respectively. In conclusion, our findings support a more extensive vaccination schedule including three doses for diphtheria and tetanus which are in line with current international guidelines.</description><identifier>ISSN: 1397-3142</identifier><identifier>EISSN: 1399-3046</identifier><identifier>DOI: 10.1111/petr.13599</identifier><identifier>PMID: 31617270</identifier><language>eng</language><publisher>Denmark: Wiley Subscription Services, Inc</publisher><subject>Adolescent ; Aftercare - methods ; Aftercare - standards ; Antibodies, Viral - blood ; antibody ; Antibody response ; Biomarkers - blood ; Child ; Child, Preschool ; Children ; Cohort analysis ; Denmark ; Diphtheria ; Female ; Follow-Up Studies ; haematopoietic cell transplantation ; Haemophilus influenzae ; Health risk assessment ; Hematopoietic Stem Cell Transplantation ; Humans ; Immunization Schedule ; Immunization, Secondary - methods ; Immunization, Secondary - standards ; Infant ; Infant, Newborn ; Logistic Models ; Male ; Measles ; Mumps ; paediatric ; Poliomyelitis ; Practice Guidelines as Topic ; Retrospective Studies ; Rubella ; Schedules ; Tetanus ; Transplantation ; vaccination ; Vaccines - administration & dosage ; Vaccines - immunology</subject><ispartof>Pediatric transplantation, 2020-02, Vol.24 (1), p.e13599-n/a</ispartof><rights>2019 Wiley Periodicals, Inc.</rights><rights>2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3169-a352e5f732a753f48e687c3b4c652de1659aec25b4df43663607f5e13caec11e3</cites><orcidid>0000-0001-7855-4036</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fpetr.13599$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fpetr.13599$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31617270$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jensen, Lotte</creatorcontrib><creatorcontrib>Poulsen, Anja</creatorcontrib><creatorcontrib>Nygaard, Ulrikka</creatorcontrib><creatorcontrib>Scheike, Thomas</creatorcontrib><creatorcontrib>Riis, Margit Schilling</creatorcontrib><creatorcontrib>Pedersen, Freddy Karup</creatorcontrib><creatorcontrib>Heilmann, Carsten</creatorcontrib><title>Antibody response to vaccination after haematopoietic cell transplantation in children using a reduced dose schedule—A retrospective cohort study</title><title>Pediatric transplantation</title><addtitle>Pediatr Transplant</addtitle><description>Children receiving HCT loose protective immunity to vaccines received pre‐HCT. Therefore, revaccination post‐HCT is of major importance. In Denmark, a vaccination schedule with fewer doses post‐HCT has been used, including two doses for diphtheria, tetanus, polio, measles, mumps, and rubella, and one dose only for Haemophilus influenzae type B. The background for this was the presumption that post‐HCT immunization constituted booster vaccination of donor immunity. Our objective was to evaluate the proportion of children protected after the scheduled vaccination programme. A nationwide retrospective cohort study of all children who have received an HCT in Denmark during 1994‐2012. Antibody levels were analysed in blood samples drawn before and after vaccination, and the probability of achieving protection after the scheduled immunization programme was estimated. A total of 198 children were included. The protection post‐immunization was as follows: diphtheria 75.3%, tetanus 89.1%, polio 97.7%, and Haemophilus influenzae type B 94.8%. For diphtheria and tetanus, the probability of achieving protection increased to 93.8% and 97.3%, respectively, after a third dose. For measles, mumps, and rubella, the probability of achieving protection was 89.4%, 80.9%, and 94.2%, respectively. In conclusion, our findings support a more extensive vaccination schedule including three doses for diphtheria and tetanus which are in line with current international guidelines.</description><subject>Adolescent</subject><subject>Aftercare - methods</subject><subject>Aftercare - standards</subject><subject>Antibodies, Viral - blood</subject><subject>antibody</subject><subject>Antibody response</subject><subject>Biomarkers - blood</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Cohort analysis</subject><subject>Denmark</subject><subject>Diphtheria</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>haematopoietic cell transplantation</subject><subject>Haemophilus influenzae</subject><subject>Health risk assessment</subject><subject>Hematopoietic Stem Cell Transplantation</subject><subject>Humans</subject><subject>Immunization Schedule</subject><subject>Immunization, Secondary - methods</subject><subject>Immunization, Secondary - standards</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Measles</subject><subject>Mumps</subject><subject>paediatric</subject><subject>Poliomyelitis</subject><subject>Practice Guidelines as Topic</subject><subject>Retrospective Studies</subject><subject>Rubella</subject><subject>Schedules</subject><subject>Tetanus</subject><subject>Transplantation</subject><subject>vaccination</subject><subject>Vaccines - administration & dosage</subject><subject>Vaccines - immunology</subject><issn>1397-3142</issn><issn>1399-3046</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctO3DAUhq0KVCjtpg-ALHVTVQq140vGyxHiUgkJhOg68tgnHaOMHWxn0Oz6DvCEfRI8BFh0gTf2sT99Osc_Ql8pOaJl_RwgxyPKhFIf0D5lSlWMcLnzfG4qRnm9hz6ldEsIlXzGP6I9RiVt6obso4e5z24R7AZHSEPwCXAOeK2NcV5nFzzWXYaIlxpWOochOMjOYAN9j3PUPg299nkincdm6XobweMxOf8H62K1owGLbSjmZJal7OHf38d5eckxpAFMdmvAJixDzDjl0W4-o91O9wm-vOwH6Pfpyc3xeXVxefbreH5RmdK_qjQTNYiuYbVuBOv4DOSsMWzBjRS1BSqF0mBqseC240xKJknTCaDMlGtKgR2g75N3iOFuhJTblUvbybSHMKa2ZkTWVM2UKui3_9DbMEZfuisU50Q05ZcL9WOiTJksRejaIbqVjpuWknYbVbuNqn2OqsCHL8pxsQL7hr5mUwA6Afeuh807qvbq5OZ6kj4BAhmi6g</recordid><startdate>202002</startdate><enddate>202002</enddate><creator>Jensen, Lotte</creator><creator>Poulsen, Anja</creator><creator>Nygaard, Ulrikka</creator><creator>Scheike, Thomas</creator><creator>Riis, Margit Schilling</creator><creator>Pedersen, Freddy Karup</creator><creator>Heilmann, Carsten</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7855-4036</orcidid></search><sort><creationdate>202002</creationdate><title>Antibody response to vaccination after haematopoietic cell transplantation in children using a reduced dose schedule—A retrospective cohort study</title><author>Jensen, Lotte ; Poulsen, Anja ; Nygaard, Ulrikka ; Scheike, Thomas ; Riis, Margit Schilling ; Pedersen, Freddy Karup ; Heilmann, Carsten</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3169-a352e5f732a753f48e687c3b4c652de1659aec25b4df43663607f5e13caec11e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adolescent</topic><topic>Aftercare - methods</topic><topic>Aftercare - standards</topic><topic>Antibodies, Viral - blood</topic><topic>antibody</topic><topic>Antibody response</topic><topic>Biomarkers - blood</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Cohort analysis</topic><topic>Denmark</topic><topic>Diphtheria</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>haematopoietic cell transplantation</topic><topic>Haemophilus influenzae</topic><topic>Health risk assessment</topic><topic>Hematopoietic Stem Cell Transplantation</topic><topic>Humans</topic><topic>Immunization Schedule</topic><topic>Immunization, Secondary - methods</topic><topic>Immunization, Secondary - standards</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Measles</topic><topic>Mumps</topic><topic>paediatric</topic><topic>Poliomyelitis</topic><topic>Practice Guidelines as Topic</topic><topic>Retrospective Studies</topic><topic>Rubella</topic><topic>Schedules</topic><topic>Tetanus</topic><topic>Transplantation</topic><topic>vaccination</topic><topic>Vaccines - administration & dosage</topic><topic>Vaccines - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jensen, Lotte</creatorcontrib><creatorcontrib>Poulsen, Anja</creatorcontrib><creatorcontrib>Nygaard, Ulrikka</creatorcontrib><creatorcontrib>Scheike, Thomas</creatorcontrib><creatorcontrib>Riis, Margit Schilling</creatorcontrib><creatorcontrib>Pedersen, Freddy Karup</creatorcontrib><creatorcontrib>Heilmann, Carsten</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jensen, Lotte</au><au>Poulsen, Anja</au><au>Nygaard, Ulrikka</au><au>Scheike, Thomas</au><au>Riis, Margit Schilling</au><au>Pedersen, Freddy Karup</au><au>Heilmann, Carsten</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antibody response to vaccination after haematopoietic cell transplantation in children using a reduced dose schedule—A retrospective cohort study</atitle><jtitle>Pediatric transplantation</jtitle><addtitle>Pediatr Transplant</addtitle><date>2020-02</date><risdate>2020</risdate><volume>24</volume><issue>1</issue><spage>e13599</spage><epage>n/a</epage><pages>e13599-n/a</pages><issn>1397-3142</issn><eissn>1399-3046</eissn><abstract>Children receiving HCT loose protective immunity to vaccines received pre‐HCT. Therefore, revaccination post‐HCT is of major importance. In Denmark, a vaccination schedule with fewer doses post‐HCT has been used, including two doses for diphtheria, tetanus, polio, measles, mumps, and rubella, and one dose only for Haemophilus influenzae type B. The background for this was the presumption that post‐HCT immunization constituted booster vaccination of donor immunity. Our objective was to evaluate the proportion of children protected after the scheduled vaccination programme. A nationwide retrospective cohort study of all children who have received an HCT in Denmark during 1994‐2012. Antibody levels were analysed in blood samples drawn before and after vaccination, and the probability of achieving protection after the scheduled immunization programme was estimated. A total of 198 children were included. The protection post‐immunization was as follows: diphtheria 75.3%, tetanus 89.1%, polio 97.7%, and Haemophilus influenzae type B 94.8%. For diphtheria and tetanus, the probability of achieving protection increased to 93.8% and 97.3%, respectively, after a third dose. For measles, mumps, and rubella, the probability of achieving protection was 89.4%, 80.9%, and 94.2%, respectively. In conclusion, our findings support a more extensive vaccination schedule including three doses for diphtheria and tetanus which are in line with current international guidelines.</abstract><cop>Denmark</cop><pub>Wiley Subscription Services, Inc</pub><pmid>31617270</pmid><doi>10.1111/petr.13599</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-7855-4036</orcidid></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1397-3142 |
ispartof | Pediatric transplantation, 2020-02, Vol.24 (1), p.e13599-n/a |
issn | 1397-3142 1399-3046 |
language | eng |
recordid | cdi_proquest_miscellaneous_2306219899 |
source | MEDLINE; Wiley Online Library All Journals |
subjects | Adolescent Aftercare - methods Aftercare - standards Antibodies, Viral - blood antibody Antibody response Biomarkers - blood Child Child, Preschool Children Cohort analysis Denmark Diphtheria Female Follow-Up Studies haematopoietic cell transplantation Haemophilus influenzae Health risk assessment Hematopoietic Stem Cell Transplantation Humans Immunization Schedule Immunization, Secondary - methods Immunization, Secondary - standards Infant Infant, Newborn Logistic Models Male Measles Mumps paediatric Poliomyelitis Practice Guidelines as Topic Retrospective Studies Rubella Schedules Tetanus Transplantation vaccination Vaccines - administration & dosage Vaccines - immunology |
title | Antibody response to vaccination after haematopoietic cell transplantation in children using a reduced dose schedule—A retrospective cohort study |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T03%3A47%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Antibody%20response%20to%20vaccination%20after%20haematopoietic%20cell%20transplantation%20in%20children%20using%20a%20reduced%20dose%20schedule%E2%80%94A%20retrospective%20cohort%20study&rft.jtitle=Pediatric%20transplantation&rft.au=Jensen,%20Lotte&rft.date=2020-02&rft.volume=24&rft.issue=1&rft.spage=e13599&rft.epage=n/a&rft.pages=e13599-n/a&rft.issn=1397-3142&rft.eissn=1399-3046&rft_id=info:doi/10.1111/petr.13599&rft_dat=%3Cproquest_cross%3E2344057142%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2344057142&rft_id=info:pmid/31617270&rfr_iscdi=true |