Antibody response to vaccination after haematopoietic cell transplantation in children using a reduced dose schedule—A retrospective cohort study

Children receiving HCT loose protective immunity to vaccines received pre‐HCT. Therefore, revaccination post‐HCT is of major importance. In Denmark, a vaccination schedule with fewer doses post‐HCT has been used, including two doses for diphtheria, tetanus, polio, measles, mumps, and rubella, and on...

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Veröffentlicht in:Pediatric transplantation 2020-02, Vol.24 (1), p.e13599-n/a
Hauptverfasser: Jensen, Lotte, Poulsen, Anja, Nygaard, Ulrikka, Scheike, Thomas, Riis, Margit Schilling, Pedersen, Freddy Karup, Heilmann, Carsten
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container_issue 1
container_start_page e13599
container_title Pediatric transplantation
container_volume 24
creator Jensen, Lotte
Poulsen, Anja
Nygaard, Ulrikka
Scheike, Thomas
Riis, Margit Schilling
Pedersen, Freddy Karup
Heilmann, Carsten
description Children receiving HCT loose protective immunity to vaccines received pre‐HCT. Therefore, revaccination post‐HCT is of major importance. In Denmark, a vaccination schedule with fewer doses post‐HCT has been used, including two doses for diphtheria, tetanus, polio, measles, mumps, and rubella, and one dose only for Haemophilus influenzae type B. The background for this was the presumption that post‐HCT immunization constituted booster vaccination of donor immunity. Our objective was to evaluate the proportion of children protected after the scheduled vaccination programme. A nationwide retrospective cohort study of all children who have received an HCT in Denmark during 1994‐2012. Antibody levels were analysed in blood samples drawn before and after vaccination, and the probability of achieving protection after the scheduled immunization programme was estimated. A total of 198 children were included. The protection post‐immunization was as follows: diphtheria 75.3%, tetanus 89.1%, polio 97.7%, and Haemophilus influenzae type B 94.8%. For diphtheria and tetanus, the probability of achieving protection increased to 93.8% and 97.3%, respectively, after a third dose. For measles, mumps, and rubella, the probability of achieving protection was 89.4%, 80.9%, and 94.2%, respectively. In conclusion, our findings support a more extensive vaccination schedule including three doses for diphtheria and tetanus which are in line with current international guidelines.
doi_str_mv 10.1111/petr.13599
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For diphtheria and tetanus, the probability of achieving protection increased to 93.8% and 97.3%, respectively, after a third dose. For measles, mumps, and rubella, the probability of achieving protection was 89.4%, 80.9%, and 94.2%, respectively. 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subjects Adolescent
Aftercare - methods
Aftercare - standards
Antibodies, Viral - blood
antibody
Antibody response
Biomarkers - blood
Child
Child, Preschool
Children
Cohort analysis
Denmark
Diphtheria
Female
Follow-Up Studies
haematopoietic cell transplantation
Haemophilus influenzae
Health risk assessment
Hematopoietic Stem Cell Transplantation
Humans
Immunization Schedule
Immunization, Secondary - methods
Immunization, Secondary - standards
Infant
Infant, Newborn
Logistic Models
Male
Measles
Mumps
paediatric
Poliomyelitis
Practice Guidelines as Topic
Retrospective Studies
Rubella
Schedules
Tetanus
Transplantation
vaccination
Vaccines - administration & dosage
Vaccines - immunology
title Antibody response to vaccination after haematopoietic cell transplantation in children using a reduced dose schedule—A retrospective cohort study
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