A positive feedback self-regulatory loop between miR-210 and HIF-1α mediated by CPEB2 is involved in trophoblast syncytialization: implication of trophoblast malfunction in preeclampsia

The pregnancy complication preeclampsia is directly associated with hypoxic stress and insufficient trophoblast cell differentiation. The hypoxia-inducible microRNA (miRNA), miR-210, has been identified as a significantly up-regulated miRNA in preeclamptic placenta, and evidence in other cell types...

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Veröffentlicht in:	Biology of reproduction 2020-03, Vol.102 (3), p.560-570
Hauptverfasser:	Wang, Hao, Zhao, Yangyu, Luo, Rongcan, Bian, Xiaotao, Wang, Yongqing, Shao, Xuan, Li, Yu-Xia, Liu, Ming, Wang, Yan-Ling
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding sites Biology Blood pressure CPEB2 HIF-1α Hypertension Hypoxia MicroRNAs miR-210 Placenta Preeclampsia Pregnancy complications Reproductive health Stem cells trophoblast syncytialization
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