Platelet and white blood cell count are independently associated with sarcopenia: A nationwide population-based study
AbstractIntroductionSarcopenia is attracting increasing attention due to its harmful impacts on health. Chronic inflammation is proposed to be a major cause of sarcopenia. Here, we aimed to identify whether white blood cell (WBC) and platelet count have independent roles in sarcopenia occurrence. Me...
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| Veröffentlicht in: | Thrombosis research 2019-11, Vol.183, p.36-44 |
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| creator | Lee, Hye Sun Koh, Il-Hyun Kim, Hyoung Sik Kwon, Yu-Jin |
| description | AbstractIntroductionSarcopenia is attracting increasing attention due to its harmful impacts on health. Chronic inflammation is proposed to be a major cause of sarcopenia. Here, we aimed to identify whether white blood cell (WBC) and platelet count have independent roles in sarcopenia occurrence. Method and materialsThis cross-sectional study analyzed 10,092 adults (4293 men and 5799 women) from the 2008–2011 Korea National Health and Nutrition Survey. Cut-off values for sarcopenia were defined as a skeletal muscle mass index |
| doi_str_mv | 10.1016/j.thromres.2019.09.007 |
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Chronic inflammation is proposed to be a major cause of sarcopenia. Here, we aimed to identify whether white blood cell (WBC) and platelet count have independent roles in sarcopenia occurrence. Method and materialsThis cross-sectional study analyzed 10,092 adults (4293 men and 5799 women) from the 2008–2011 Korea National Health and Nutrition Survey. Cut-off values for sarcopenia were defined as a skeletal muscle mass index <0.789 for men and <0.512 for women. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) using multiple logistic regression analysis after adjusting for confounding variables. ROC curve analysis was used to evaluate the ability of platelet count and white blood cell count to discriminate the presence of sarcopenia. ResultsAfter adjusting for possible confounders, the OR (95% CI) for sarcopenia occurrence according to platelet counts was 1.62 (1.20–2.19) for the T3 group in men and 1.72 (1.28–2.31) for the T3 group in women, relative to the lowest platelet count tertile. After adjusting for same confounders, the ORs (95% CI) for sarcopenia occurrence according to WBC counts was 1.86 (1.35–2.57) for the T3 group in men, and 2.36 (1.77–3.13) for the T3 group in women, relative to the lowest WBC count tertile. We also found independent significant associations between platelet count, WBC count, and sarcopenia. ConclusionsHigher platelet and WBC counts within the normal range are each independently associated with sarcopenia in Korean men and women. The inclusion of platelet, WBC, or combined platelet and WBC counts significantly improved the power to discriminate sarcopenia.</description><identifier>ISSN: 0049-3848</identifier><identifier>EISSN: 1879-2472</identifier><identifier>DOI: 10.1016/j.thromres.2019.09.007</identifier><identifier>PMID: 31614293</identifier><language>eng</language><publisher>United States: Elsevier Ltd</publisher><subject>Adult ; Chronic inflammation ; Cross-Sectional Studies ; Female ; Hematology, Oncology, and Palliative Medicine ; Humans ; Leukocyte Count - methods ; Male ; Middle Aged ; Platelet ; Platelet Count - methods ; Sarcopenia ; Sarcopenia - blood ; White blood cell</subject><ispartof>Thrombosis research, 2019-11, Vol.183, p.36-44</ispartof><rights>2019 Elsevier Ltd</rights><rights>Copyright © 2019 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-9824744489b336a282212795551e9bcec50abae046fd22c4010d25075d7af9f53</citedby><cites>FETCH-LOGICAL-c423t-9824744489b336a282212795551e9bcec50abae046fd22c4010d25075d7af9f53</cites><orcidid>0000-0001-6328-6948 ; 0000-0002-9021-3856</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.thromres.2019.09.007$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31614293$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Hye Sun</creatorcontrib><creatorcontrib>Koh, Il-Hyun</creatorcontrib><creatorcontrib>Kim, Hyoung Sik</creatorcontrib><creatorcontrib>Kwon, Yu-Jin</creatorcontrib><title>Platelet and white blood cell count are independently associated with sarcopenia: A nationwide population-based study</title><title>Thrombosis research</title><addtitle>Thromb Res</addtitle><description>AbstractIntroductionSarcopenia is attracting increasing attention due to its harmful impacts on health. Chronic inflammation is proposed to be a major cause of sarcopenia. Here, we aimed to identify whether white blood cell (WBC) and platelet count have independent roles in sarcopenia occurrence. Method and materialsThis cross-sectional study analyzed 10,092 adults (4293 men and 5799 women) from the 2008–2011 Korea National Health and Nutrition Survey. Cut-off values for sarcopenia were defined as a skeletal muscle mass index <0.789 for men and <0.512 for women. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) using multiple logistic regression analysis after adjusting for confounding variables. ROC curve analysis was used to evaluate the ability of platelet count and white blood cell count to discriminate the presence of sarcopenia. ResultsAfter adjusting for possible confounders, the OR (95% CI) for sarcopenia occurrence according to platelet counts was 1.62 (1.20–2.19) for the T3 group in men and 1.72 (1.28–2.31) for the T3 group in women, relative to the lowest platelet count tertile. After adjusting for same confounders, the ORs (95% CI) for sarcopenia occurrence according to WBC counts was 1.86 (1.35–2.57) for the T3 group in men, and 2.36 (1.77–3.13) for the T3 group in women, relative to the lowest WBC count tertile. We also found independent significant associations between platelet count, WBC count, and sarcopenia. ConclusionsHigher platelet and WBC counts within the normal range are each independently associated with sarcopenia in Korean men and women. The inclusion of platelet, WBC, or combined platelet and WBC counts significantly improved the power to discriminate sarcopenia.</description><subject>Adult</subject><subject>Chronic inflammation</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Hematology, Oncology, and Palliative Medicine</subject><subject>Humans</subject><subject>Leukocyte Count - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Platelet</subject><subject>Platelet Count - methods</subject><subject>Sarcopenia</subject><subject>Sarcopenia - blood</subject><subject>White blood cell</subject><issn>0049-3848</issn><issn>1879-2472</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUU2LFDEQbURxx9W_sOTopcfKV3fHg7gsfsGCgnoO6aSGyZjptEnaZf69aWfXgxehSCjqvVe8V01zRWFLgXavDtuyT_GYMG8ZULWFWtA_ajZ06FXLRM8eNxsAoVo-iOGieZbzAYD2VMmnzQWnHRVM8U2zfAmmYMBCzOTI3d4XJGOI0RGLIRAbl6mOEhI_OZyxPlMJJ2JyjtZXZuX4sifZJBvr2JvX5JpMpvg43XmHZI7zEv607WhyheeyuNPz5snOhIwv7v_L5vv7d99uPra3nz98urm-ba1gvLRqqEaEEIMaOe8MGxijrFdSSopqtGglmNEgiG7nGLMCKDgmoZeuNzu1k_yyeXnWnVP8uWAu-ujzasxMGJesGYeuSkrZV2h3htoUc06403PyR5NOmoJeI9cH_RC5XiPXUAtW4tX9jmU8ovtLe8i4At6eAVid_vKYdLYeJ4vOJ7RFu-j_v-PNPxI2-MlbE37gCfMhLmmqOWqqM9Ogv66HX-9OFQcBvOe_AZ4grEc</recordid><startdate>20191101</startdate><enddate>20191101</enddate><creator>Lee, Hye Sun</creator><creator>Koh, Il-Hyun</creator><creator>Kim, Hyoung Sik</creator><creator>Kwon, Yu-Jin</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6328-6948</orcidid><orcidid>https://orcid.org/0000-0002-9021-3856</orcidid></search><sort><creationdate>20191101</creationdate><title>Platelet and white blood cell count are independently associated with sarcopenia: A nationwide population-based study</title><author>Lee, Hye Sun ; Koh, Il-Hyun ; Kim, Hyoung Sik ; Kwon, Yu-Jin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-9824744489b336a282212795551e9bcec50abae046fd22c4010d25075d7af9f53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Chronic inflammation</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Hematology, Oncology, and Palliative Medicine</topic><topic>Humans</topic><topic>Leukocyte Count - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Platelet</topic><topic>Platelet Count - methods</topic><topic>Sarcopenia</topic><topic>Sarcopenia - blood</topic><topic>White blood cell</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Hye Sun</creatorcontrib><creatorcontrib>Koh, Il-Hyun</creatorcontrib><creatorcontrib>Kim, Hyoung Sik</creatorcontrib><creatorcontrib>Kwon, Yu-Jin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Thrombosis research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Hye Sun</au><au>Koh, Il-Hyun</au><au>Kim, Hyoung Sik</au><au>Kwon, Yu-Jin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Platelet and white blood cell count are independently associated with sarcopenia: A nationwide population-based study</atitle><jtitle>Thrombosis research</jtitle><addtitle>Thromb Res</addtitle><date>2019-11-01</date><risdate>2019</risdate><volume>183</volume><spage>36</spage><epage>44</epage><pages>36-44</pages><issn>0049-3848</issn><eissn>1879-2472</eissn><abstract>AbstractIntroductionSarcopenia is attracting increasing attention due to its harmful impacts on health. Chronic inflammation is proposed to be a major cause of sarcopenia. Here, we aimed to identify whether white blood cell (WBC) and platelet count have independent roles in sarcopenia occurrence. Method and materialsThis cross-sectional study analyzed 10,092 adults (4293 men and 5799 women) from the 2008–2011 Korea National Health and Nutrition Survey. Cut-off values for sarcopenia were defined as a skeletal muscle mass index <0.789 for men and <0.512 for women. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) using multiple logistic regression analysis after adjusting for confounding variables. ROC curve analysis was used to evaluate the ability of platelet count and white blood cell count to discriminate the presence of sarcopenia. ResultsAfter adjusting for possible confounders, the OR (95% CI) for sarcopenia occurrence according to platelet counts was 1.62 (1.20–2.19) for the T3 group in men and 1.72 (1.28–2.31) for the T3 group in women, relative to the lowest platelet count tertile. After adjusting for same confounders, the ORs (95% CI) for sarcopenia occurrence according to WBC counts was 1.86 (1.35–2.57) for the T3 group in men, and 2.36 (1.77–3.13) for the T3 group in women, relative to the lowest WBC count tertile. We also found independent significant associations between platelet count, WBC count, and sarcopenia. ConclusionsHigher platelet and WBC counts within the normal range are each independently associated with sarcopenia in Korean men and women. The inclusion of platelet, WBC, or combined platelet and WBC counts significantly improved the power to discriminate sarcopenia.</abstract><cop>United States</cop><pub>Elsevier Ltd</pub><pmid>31614293</pmid><doi>10.1016/j.thromres.2019.09.007</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-6328-6948</orcidid><orcidid>https://orcid.org/0000-0002-9021-3856</orcidid></addata></record> |
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| subjects | Adult Chronic inflammation Cross-Sectional Studies Female Hematology, Oncology, and Palliative Medicine Humans Leukocyte Count - methods Male Middle Aged Platelet Platelet Count - methods Sarcopenia Sarcopenia - blood White blood cell |
| title | Platelet and white blood cell count are independently associated with sarcopenia: A nationwide population-based study |
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