pH-Responsive Nanoprobe for In Vivo Photoacoustic Imaging of Gastric Acid
In vivo real-time monitoring gastric acid is of great importance for diagnosis and treatment of gastrointestinal diseases. Herein, we synthesized a pH-responsive photoacoustic (PA) nanoprobe (denoted as LET-4) based on near-infrared (NIR) dye (IR1061) for in vivo photoacoustic imaging (PAI) of gastr...
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| Veröffentlicht in: | Analytical chemistry (Washington) 2019-11, Vol.91 (21), p.13570-13575 |
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| container_title | Analytical chemistry (Washington) |
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| creator | Ma, Gongcheng Gao, Xiaoting Jiang, Chao Xing, Shaojun Wei, Chaoliang Huang, Peng Lin, Jing |
| description | In vivo real-time monitoring gastric acid is of great importance for diagnosis and treatment of gastrointestinal diseases. Herein, we synthesized a pH-responsive photoacoustic (PA) nanoprobe (denoted as LET-4) based on near-infrared (NIR) dye (IR1061) for in vivo photoacoustic imaging (PAI) of gastric acid in living subjects. In the acidic condition, the protonated LET-4 nanoprobe has a strong absorbance peak at 808 nm, followed by a strong PA signal output at 808 nm. The PA808 signal at pH 3 is 3.45-fold higher than the signal at pH 7. More importantly, the LET-4 nanoprobe could monitor in vivo gastric acid secretion assessment in animal model using PAI. This organic small molecule NIR dye-based probe with simple components, facile preparation, good biocompatibility, and rapid excretion has great potential for gastrointestinal disease diagnosis. |
| doi_str_mv | 10.1021/acs.analchem.9b02701 |
| format | Article |
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Herein, we synthesized a pH-responsive photoacoustic (PA) nanoprobe (denoted as LET-4) based on near-infrared (NIR) dye (IR1061) for in vivo photoacoustic imaging (PAI) of gastric acid in living subjects. In the acidic condition, the protonated LET-4 nanoprobe has a strong absorbance peak at 808 nm, followed by a strong PA signal output at 808 nm. The PA808 signal at pH 3 is 3.45-fold higher than the signal at pH 7. More importantly, the LET-4 nanoprobe could monitor in vivo gastric acid secretion assessment in animal model using PAI. This organic small molecule NIR dye-based probe with simple components, facile preparation, good biocompatibility, and rapid excretion has great potential for gastrointestinal disease diagnosis.</description><identifier>ISSN: 0003-2700</identifier><identifier>EISSN: 1520-6882</identifier><identifier>DOI: 10.1021/acs.analchem.9b02701</identifier><identifier>PMID: 31610654</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Acids ; Analytical chemistry ; Animal models ; Biocompatibility ; Chemistry ; Diagnosis ; Dyes ; Gastric juice ; Gastrointestinal diseases ; Histamine ; Medical imaging ; Medical treatment ; pH effects ; Secretion</subject><ispartof>Analytical chemistry (Washington), 2019-11, Vol.91 (21), p.13570-13575</ispartof><rights>Copyright American Chemical Society Nov 5, 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a376t-887003499e004da05fa900e3b2cf484ef4788d52f64de560b726027f83cea5bb3</citedby><cites>FETCH-LOGICAL-a376t-887003499e004da05fa900e3b2cf484ef4788d52f64de560b726027f83cea5bb3</cites><orcidid>0000-0001-9865-2098 ; 0000-0003-3651-7813</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/acs.analchem.9b02701$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/acs.analchem.9b02701$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,778,782,2754,27063,27911,27912,56725,56775</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31610654$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ma, Gongcheng</creatorcontrib><creatorcontrib>Gao, Xiaoting</creatorcontrib><creatorcontrib>Jiang, Chao</creatorcontrib><creatorcontrib>Xing, Shaojun</creatorcontrib><creatorcontrib>Wei, Chaoliang</creatorcontrib><creatorcontrib>Huang, Peng</creatorcontrib><creatorcontrib>Lin, Jing</creatorcontrib><title>pH-Responsive Nanoprobe for In Vivo Photoacoustic Imaging of Gastric Acid</title><title>Analytical chemistry (Washington)</title><addtitle>Anal. 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This organic small molecule NIR dye-based probe with simple components, facile preparation, good biocompatibility, and rapid excretion has great potential for gastrointestinal disease diagnosis.</description><subject>Acids</subject><subject>Analytical chemistry</subject><subject>Animal models</subject><subject>Biocompatibility</subject><subject>Chemistry</subject><subject>Diagnosis</subject><subject>Dyes</subject><subject>Gastric juice</subject><subject>Gastrointestinal diseases</subject><subject>Histamine</subject><subject>Medical imaging</subject><subject>Medical treatment</subject><subject>pH effects</subject><subject>Secretion</subject><issn>0003-2700</issn><issn>1520-6882</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kF1LwzAUhoMobk7_gUjBG286T9ImTS_H0K0wVES9DWmabB1tM5t24L83Yx8XXngVODzvm3MehG4xjDEQ_CiVG8tGVmql63GaA0kAn6EhpgRCxjk5R0MAiEI_hwG6cm4NgDFgdokGEWYYGI2HKNvMw3ftNrZx5VYHL7Kxm9bmOjC2DbIm-Cq3Nnhb2c5KZXvXlSrIarksm2VgTTCTrmv9aKLK4hpdGFk5fXN4R-jz-eljOg8Xr7NsOlmEMkpYF3Lu94niNNUAcSGBGpkC6CgnysQ81iZOOC8oMSwuNGWQJ4T52wyPlJY0z6MRetj3-j2_e-06UZdO6aqSjfYbChIBTdKUAvXo_R90bfvWO9tRmCRJwoF5Kt5TqrXOtdqITVvWsv0RGMROtfCqxVG1OKj2sbtDeZ_XujiFjm49AHtgFz99_G_nL8ADi3s</recordid><startdate>20191105</startdate><enddate>20191105</enddate><creator>Ma, Gongcheng</creator><creator>Gao, Xiaoting</creator><creator>Jiang, Chao</creator><creator>Xing, Shaojun</creator><creator>Wei, Chaoliang</creator><creator>Huang, Peng</creator><creator>Lin, Jing</creator><general>American Chemical Society</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7TM</scope><scope>7U5</scope><scope>7U7</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9865-2098</orcidid><orcidid>https://orcid.org/0000-0003-3651-7813</orcidid></search><sort><creationdate>20191105</creationdate><title>pH-Responsive Nanoprobe for In Vivo Photoacoustic Imaging of Gastric Acid</title><author>Ma, Gongcheng ; 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| subjects | Acids Analytical chemistry Animal models Biocompatibility Chemistry Diagnosis Dyes Gastric juice Gastrointestinal diseases Histamine Medical imaging Medical treatment pH effects Secretion |
| title | pH-Responsive Nanoprobe for In Vivo Photoacoustic Imaging of Gastric Acid |
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