The role of N6‐methyladenosine modification on diapause in silkworm (Bombyx mori) strains that exhibit different voltinism
N6‐methyladenosine (m6A) plays a key role in regulating gene expression in myriad organisms. Diapause is an important plastic phenotype that allows insects to survive under specific environmental conditions. However, the diapause molecular mechanism remains unknown. In this study, we analyzed the ph...
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| Veröffentlicht in: | Molecular reproduction and development 2019-12, Vol.86 (12), p.1981-1992 |
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| container_end_page | 1992 |
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| container_issue | 12 |
| container_start_page | 1981 |
| container_title | Molecular reproduction and development |
| container_volume | 86 |
| creator | Jiang, Tao Li, Jiashuang Qian, Ping Xue, Peng Xu, Jin Chen, Yanrong Zhu, Juan Tang, Shunming Zhao, Qiaoling Qian, Heying Shen, Xingjia |
| description | N6‐methyladenosine (m6A) plays a key role in regulating gene expression in myriad organisms. Diapause is an important plastic phenotype that allows insects to survive under specific environmental conditions. However, the diapause molecular mechanism remains unknown. In this study, we analyzed the phylogenetics of genes related to the m6A modification complex in the silkworm (Bombyx mori) based on identified sequences from other organisms. We detected the expression of these genes during different developmental phases from four strains with different voltinism. We also determined total m6A content in cells treated with different diapause hormone concentrations or eggs exposed to hydrochloric acid. Our data revealed that m6A‐modification‐related gene expression and m6A content were greater in diapause‐destinated compared to nondiapause‐destined strains. Our findings suggest that m6A modification may provide significant epigenetic regulation of diapause‐related genes in the silkworm.
N6‐methyladenosine (m6A)‐modification‐related gene expression and m6A content were greater in diapause‐destinated compared to nondiapause‐destined strains. Our findings suggest that m6A modification may provide significant epigenetic regulation of diapause‐related genes in the silkworm. |
| doi_str_mv | 10.1002/mrd.23283 |
| format | Article |
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N6‐methyladenosine (m6A)‐modification‐related gene expression and m6A content were greater in diapause‐destinated compared to nondiapause‐destined strains. Our findings suggest that m6A modification may provide significant epigenetic regulation of diapause‐related genes in the silkworm.</description><identifier>ISSN: 1040-452X</identifier><identifier>EISSN: 1098-2795</identifier><identifier>DOI: 10.1002/mrd.23283</identifier><identifier>PMID: 31612574</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Bombyx mori ; Diapause ; Eggs ; Environmental conditions ; Epigenetics ; Gene expression ; Gene regulation ; Hydrochloric acid ; N6-methyladenosine ; Phenotypes ; Phenotypic plasticity ; Phylogeny ; response ; RNA methylation ; Strains (organisms) ; Voltinism</subject><ispartof>Molecular reproduction and development, 2019-12, Vol.86 (12), p.1981-1992</ispartof><rights>2019 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3533-5ea972a6303fed6b9ec065b6dd09180dcd58f285c7869532d44d78f36ba623c23</citedby><cites>FETCH-LOGICAL-c3533-5ea972a6303fed6b9ec065b6dd09180dcd58f285c7869532d44d78f36ba623c23</cites><orcidid>0000-0002-3539-3292</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmrd.23283$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmrd.23283$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31612574$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jiang, Tao</creatorcontrib><creatorcontrib>Li, Jiashuang</creatorcontrib><creatorcontrib>Qian, Ping</creatorcontrib><creatorcontrib>Xue, Peng</creatorcontrib><creatorcontrib>Xu, Jin</creatorcontrib><creatorcontrib>Chen, Yanrong</creatorcontrib><creatorcontrib>Zhu, Juan</creatorcontrib><creatorcontrib>Tang, Shunming</creatorcontrib><creatorcontrib>Zhao, Qiaoling</creatorcontrib><creatorcontrib>Qian, Heying</creatorcontrib><creatorcontrib>Shen, Xingjia</creatorcontrib><title>The role of N6‐methyladenosine modification on diapause in silkworm (Bombyx mori) strains that exhibit different voltinism</title><title>Molecular reproduction and development</title><addtitle>Mol Reprod Dev</addtitle><description>N6‐methyladenosine (m6A) plays a key role in regulating gene expression in myriad organisms. Diapause is an important plastic phenotype that allows insects to survive under specific environmental conditions. However, the diapause molecular mechanism remains unknown. In this study, we analyzed the phylogenetics of genes related to the m6A modification complex in the silkworm (Bombyx mori) based on identified sequences from other organisms. We detected the expression of these genes during different developmental phases from four strains with different voltinism. We also determined total m6A content in cells treated with different diapause hormone concentrations or eggs exposed to hydrochloric acid. Our data revealed that m6A‐modification‐related gene expression and m6A content were greater in diapause‐destinated compared to nondiapause‐destined strains. Our findings suggest that m6A modification may provide significant epigenetic regulation of diapause‐related genes in the silkworm.
N6‐methyladenosine (m6A)‐modification‐related gene expression and m6A content were greater in diapause‐destinated compared to nondiapause‐destined strains. Our findings suggest that m6A modification may provide significant epigenetic regulation of diapause‐related genes in the silkworm.</description><subject>Bombyx mori</subject><subject>Diapause</subject><subject>Eggs</subject><subject>Environmental conditions</subject><subject>Epigenetics</subject><subject>Gene expression</subject><subject>Gene regulation</subject><subject>Hydrochloric acid</subject><subject>N6-methyladenosine</subject><subject>Phenotypes</subject><subject>Phenotypic plasticity</subject><subject>Phylogeny</subject><subject>response</subject><subject>RNA methylation</subject><subject>Strains (organisms)</subject><subject>Voltinism</subject><issn>1040-452X</issn><issn>1098-2795</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp10c1qFTEYBuAgiq3VhTcgATftYtr8TDKZpdafFloFqeBuyEy-cFInyWmSsT3gwkvwGr0SU0_rQhACXxZPXj7yIvSckkNKCDvyyRwyzhR_gHYp6VXDul48vL23pGkF-7KDnuR8SQjpe0Ueox1OJWWia3fR94sV4BRnwNHiD_LXj58eymozawMhZhcA-2icdZMuLgZcj3F6rZcM2AWc3fz1OiaP919HP25uKk7uAOeStAsZl5UuGG5WbnSlvrMWEoSCv8W5uOCyf4oeWT1neHY399Dnd28vjk-as4_vT49fnTUTF5w3AnTfMS054RaMHHuYiBSjNIb0VBEzGaEsU2LqlOwFZ6ZtTacsl6OWjE-M76H9be46xasFchm8yxPMsw4QlzwwTkT9sY7QSl_-Qy_jkkLdriomKO2oklUdbNWUYs4J7LBOzuu0GSgZbisZaiXDn0qqfXGXuIwezF9530EFR1tw7WbY_D9pOP_0Zhv5Gze4ly0</recordid><startdate>201912</startdate><enddate>201912</enddate><creator>Jiang, Tao</creator><creator>Li, Jiashuang</creator><creator>Qian, Ping</creator><creator>Xue, Peng</creator><creator>Xu, Jin</creator><creator>Chen, Yanrong</creator><creator>Zhu, Juan</creator><creator>Tang, Shunming</creator><creator>Zhao, Qiaoling</creator><creator>Qian, Heying</creator><creator>Shen, Xingjia</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3539-3292</orcidid></search><sort><creationdate>201912</creationdate><title>The role of N6‐methyladenosine modification on diapause in silkworm (Bombyx mori) strains that exhibit different voltinism</title><author>Jiang, Tao ; Li, Jiashuang ; Qian, Ping ; Xue, Peng ; Xu, Jin ; Chen, Yanrong ; Zhu, Juan ; Tang, Shunming ; Zhao, Qiaoling ; Qian, Heying ; Shen, Xingjia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3533-5ea972a6303fed6b9ec065b6dd09180dcd58f285c7869532d44d78f36ba623c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Bombyx mori</topic><topic>Diapause</topic><topic>Eggs</topic><topic>Environmental conditions</topic><topic>Epigenetics</topic><topic>Gene expression</topic><topic>Gene regulation</topic><topic>Hydrochloric acid</topic><topic>N6-methyladenosine</topic><topic>Phenotypes</topic><topic>Phenotypic plasticity</topic><topic>Phylogeny</topic><topic>response</topic><topic>RNA methylation</topic><topic>Strains (organisms)</topic><topic>Voltinism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jiang, Tao</creatorcontrib><creatorcontrib>Li, Jiashuang</creatorcontrib><creatorcontrib>Qian, Ping</creatorcontrib><creatorcontrib>Xue, Peng</creatorcontrib><creatorcontrib>Xu, Jin</creatorcontrib><creatorcontrib>Chen, Yanrong</creatorcontrib><creatorcontrib>Zhu, Juan</creatorcontrib><creatorcontrib>Tang, Shunming</creatorcontrib><creatorcontrib>Zhao, Qiaoling</creatorcontrib><creatorcontrib>Qian, Heying</creatorcontrib><creatorcontrib>Shen, Xingjia</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular reproduction and development</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jiang, Tao</au><au>Li, Jiashuang</au><au>Qian, Ping</au><au>Xue, Peng</au><au>Xu, Jin</au><au>Chen, Yanrong</au><au>Zhu, Juan</au><au>Tang, Shunming</au><au>Zhao, Qiaoling</au><au>Qian, Heying</au><au>Shen, Xingjia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of N6‐methyladenosine modification on diapause in silkworm (Bombyx mori) strains that exhibit different voltinism</atitle><jtitle>Molecular reproduction and development</jtitle><addtitle>Mol Reprod Dev</addtitle><date>2019-12</date><risdate>2019</risdate><volume>86</volume><issue>12</issue><spage>1981</spage><epage>1992</epage><pages>1981-1992</pages><issn>1040-452X</issn><eissn>1098-2795</eissn><abstract>N6‐methyladenosine (m6A) plays a key role in regulating gene expression in myriad organisms. Diapause is an important plastic phenotype that allows insects to survive under specific environmental conditions. However, the diapause molecular mechanism remains unknown. In this study, we analyzed the phylogenetics of genes related to the m6A modification complex in the silkworm (Bombyx mori) based on identified sequences from other organisms. We detected the expression of these genes during different developmental phases from four strains with different voltinism. We also determined total m6A content in cells treated with different diapause hormone concentrations or eggs exposed to hydrochloric acid. Our data revealed that m6A‐modification‐related gene expression and m6A content were greater in diapause‐destinated compared to nondiapause‐destined strains. Our findings suggest that m6A modification may provide significant epigenetic regulation of diapause‐related genes in the silkworm.
N6‐methyladenosine (m6A)‐modification‐related gene expression and m6A content were greater in diapause‐destinated compared to nondiapause‐destined strains. Our findings suggest that m6A modification may provide significant epigenetic regulation of diapause‐related genes in the silkworm.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>31612574</pmid><doi>10.1002/mrd.23283</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-3539-3292</orcidid></addata></record> |
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| ispartof | Molecular reproduction and development, 2019-12, Vol.86 (12), p.1981-1992 |
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| subjects | Bombyx mori Diapause Eggs Environmental conditions Epigenetics Gene expression Gene regulation Hydrochloric acid N6-methyladenosine Phenotypes Phenotypic plasticity Phylogeny response RNA methylation Strains (organisms) Voltinism |
| title | The role of N6‐methyladenosine modification on diapause in silkworm (Bombyx mori) strains that exhibit different voltinism |
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