Substrate stiffness affects the immunosuppressive and trophic function of hMSCs via modulating cytoskeletal polymerization and tension

Mesenchymal stem cells (MSCs) have broad therapeutic potential due to their ability to secrete bioactive factors that are immunomodulatory and trophic (regenerative). In this study, polyacrylamide (PAAm) hydrogels with different stiffness are used as a model to explore the effects of substrate stiff...

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Veröffentlicht in:	Biomaterials science 2019-12, Vol.7 (12), p.5292-5300
Hauptverfasser:	Ji, Yurong, Li, Jing, Wei, Yingqi, Gao, Wendong, Fu, Xiaoling, Wang, Yingjun
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylic Resins - pharmacology Amides - pharmacology Cell Movement - drug effects Cells, Cultured Coculture Techniques Culture Media, Conditioned - chemistry Elastic Modulus Endothelial cells Human Umbilical Vein Endothelial Cells Humans Hydrogels Macrophages Mesenchymal Stem Cells - cytology Mesenchymal Stem Cells - metabolism Myosin Paracrine Communication - drug effects Polyacrylamide Polymerization Pyridines - pharmacology Secretions Stem cells Stiffness Substrate inhibition
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