Clonal diversity of MYC amplification evaluated by fluorescent in situ hybridisation and digital droplet polymerase chain reaction in oesophagogastric cancer: Results from a prospective clinical trial screening programme

The MYC proto-oncogene is among the most commonly dysregulated genes in human cancers. We report screening data from the iMYC trial, an ongoing phase II study assessing ibrutinib monotherapy in advanced pretreated MYC- and/or HER2-amplified oesophagogastric cancer, representing the first attempt to...

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Veröffentlicht in:	European journal of cancer (1990) 2019-11, Vol.122, p.12-21
Hauptverfasser:	Davidson, Michael, Aronson, Lauren I., Howard-Reeves, Julie, Bryant, Hanna, Cutts, Rosalind J., Hulkki-Wilson, Sanna, Kouvelakis, Kyriakos, Kalaitzaki, Eftheleria, Watkins, David, Starling, Naureen, Rao, Sheela, Cardenosa, Marta Llorca, Begum, Ruwaida, Rana, Isma, Lazaro-Alcausi, Retchel, Terlizzo, Monica, Wotherspoon, Andrew, Brown, Gina, Swansbury, John, Lord, Christopher J., Cunningham, David, Chau, Ian, Chong, Irene Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Amplification Biomarkers Biomarkers, Tumor - genetics Cancer Chemotherapy Clonal diversity Deoxyribonucleic acid Digital PCR DNA Droplets Early Detection of Cancer - methods ErbB-2 protein Esophageal Neoplasms - diagnosis Esophageal Neoplasms - genetics Female FISH Fluorescence Heterogeneity Humans Hybridization In Situ Hybridization, Fluorescence - methods Male Middle Aged MYC Myc protein Oesophagogastric cancer Polymerase chain reaction Polymerase Chain Reaction - methods Prospective screening Prospective Studies Proto-Oncogene Mas Proto-Oncogene Proteins c-myc - genetics Screening Stomach Neoplasms - diagnosis Stomach Neoplasms - genetics Therapeutic targets Tumors
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