Genetic polymorphisms of the SHBG gene can be the effect on SHBG and HDL-cholesterol levels in Coronary Heart Disease: a case–control study
Sex hormone binding globulin (SHBG) level is positively associated with the high-density lipoprotein cholesterol (HDL-C) levels. The aim of this study was to investigate the effects of the SHBG gene variations (D356N, rs1799941, and P156L) on SHBG and HDL-C levels and Coronary Heart Disease (CHD) ri...
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| Veröffentlicht in: | Molecular biology reports 2019-08, Vol.46 (4), p.4259-4269 |
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| description | Sex hormone binding globulin (SHBG) level is positively associated with the high-density lipoprotein cholesterol (HDL-C) levels. The aim of this study was to investigate the effects of the SHBG gene variations (D356N, rs1799941, and P156L) on SHBG and HDL-C levels and Coronary Heart Disease (CHD) risk. The SHBG D356 N (rs6259,G > A), P156L (rs6258,C > T), and rs1799941(G > A) polymorphisms were determined in 131 male CHD patients and 55 male controls by PCR-RFLP and real-time PCR techniques. SHGB levels were measured by Electro-chemiluminescence immunoassay (ECLIA). In the patients who had SHBG levels lower than threshold 35 nmol/l value, the risk of being HDL-C levels lower than threshold 0.90 mmol/l value was observed statistically significant (p = 0.017; OR 2.522, 95% CI 1.170–5.438). The rs1799941 GG was associated with increased CHD risk when compared with the A allele carriers (GA + AA) (p = 0.019, OR 2.222, 95% CI 1.130–4.371). In addition, the rs1799941 GG genotype and D356 N N allele were associated with lower SHBG in the CHD group (p |
| doi_str_mv | 10.1007/s11033-019-04880-x |
| format | Article |
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The aim of this study was to investigate the effects of the SHBG gene variations (D356N, rs1799941, and P156L) on SHBG and HDL-C levels and Coronary Heart Disease (CHD) risk. The SHBG D356 N (rs6259,G > A), P156L (rs6258,C > T), and rs1799941(G > A) polymorphisms were determined in 131 male CHD patients and 55 male controls by PCR-RFLP and real-time PCR techniques. SHGB levels were measured by Electro-chemiluminescence immunoassay (ECLIA). In the patients who had SHBG levels lower than threshold 35 nmol/l value, the risk of being HDL-C levels lower than threshold 0.90 mmol/l value was observed statistically significant (p = 0.017; OR 2.522, 95% CI 1.170–5.438). The rs1799941 GG was associated with increased CHD risk when compared with the A allele carriers (GA + AA) (p = 0.019, OR 2.222, 95% CI 1.130–4.371). In addition, the rs1799941 GG genotype and D356 N N allele were associated with lower SHBG in the CHD group (p < 0.01). The logistic regression analysis also revealed the rs1799941 GG genotype was significantly associated with low SHBG in CHD patients. It was observed that Haplotype-1(rs1799941 G allele—P156L P allele—D356 N D allele) was associated with increased CHD risk, while Haplotype-2 (rs1799941 rare A allele-P156L C allele- D356 N G allele) was correlated with the decreased CHD risk (p = 0.0167). Our findings suggest that there is a positive correlation between SHBG and HDL-C levels in CHD patients, and this association might be affected by SHBG gene variations.</description><identifier>ISSN: 0301-4851</identifier><identifier>EISSN: 1573-4978</identifier><identifier>DOI: 10.1007/s11033-019-04880-x</identifier><identifier>PMID: 31111369</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Adult ; Alleles ; Animal Anatomy ; Animal Biochemistry ; Biomedical and Life Sciences ; Cardiovascular disease ; Case-Control Studies ; Chemiluminescence ; Cholesterol ; Cholesterol, HDL - genetics ; Coronary artery disease ; coronary disease ; Coronary Disease - genetics ; electrochemiluminescence ; Gene Frequency ; Genotype ; Globulins ; Haplotypes ; Health risk assessment ; Heart diseases ; High density lipoprotein ; high density lipoprotein cholesterol ; Histology ; Humans ; immunoassays ; Life Sciences ; Male ; males ; Middle Aged ; Morphology ; Original Article ; Polymerase chain reaction ; Polymorphism, Single Nucleotide ; quantitative polymerase chain reaction ; regression analysis ; Restriction fragment length polymorphism ; risk ; Risk Factors ; Sex Hormone-Binding Globulin - genetics ; Sex Hormone-Binding Globulin - metabolism ; Statistical analysis</subject><ispartof>Molecular biology reports, 2019-08, Vol.46 (4), p.4259-4269</ispartof><rights>Springer Nature B.V. 2019</rights><rights>Molecular Biology Reports is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-a40e643079d3fdfc36f55cb51d9a343b1fc1fed690551a7f8fc4a27c8f39b6ba3</citedby><cites>FETCH-LOGICAL-c408t-a40e643079d3fdfc36f55cb51d9a343b1fc1fed690551a7f8fc4a27c8f39b6ba3</cites><orcidid>0000-0002-9904-0146 ; 0000-0001-7938-6281 ; 0000-0003-3618-0560 ; 0000-0001-9827-5253 ; 0000-0002-8837-6664</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11033-019-04880-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11033-019-04880-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31111369$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kurnaz-Gomleksiz, Ozlem</creatorcontrib><creatorcontrib>Akadam-Teker, Basak</creatorcontrib><creatorcontrib>Bugra, Zehra</creatorcontrib><creatorcontrib>Omer, Beyhan</creatorcontrib><creatorcontrib>Yilmaz-Aydogan, Hulya</creatorcontrib><title>Genetic polymorphisms of the SHBG gene can be the effect on SHBG and HDL-cholesterol levels in Coronary Heart Disease: a case–control study</title><title>Molecular biology reports</title><addtitle>Mol Biol Rep</addtitle><addtitle>Mol Biol Rep</addtitle><description>Sex hormone binding globulin (SHBG) level is positively associated with the high-density lipoprotein cholesterol (HDL-C) levels. The aim of this study was to investigate the effects of the SHBG gene variations (D356N, rs1799941, and P156L) on SHBG and HDL-C levels and Coronary Heart Disease (CHD) risk. The SHBG D356 N (rs6259,G > A), P156L (rs6258,C > T), and rs1799941(G > A) polymorphisms were determined in 131 male CHD patients and 55 male controls by PCR-RFLP and real-time PCR techniques. SHGB levels were measured by Electro-chemiluminescence immunoassay (ECLIA). In the patients who had SHBG levels lower than threshold 35 nmol/l value, the risk of being HDL-C levels lower than threshold 0.90 mmol/l value was observed statistically significant (p = 0.017; OR 2.522, 95% CI 1.170–5.438). The rs1799941 GG was associated with increased CHD risk when compared with the A allele carriers (GA + AA) (p = 0.019, OR 2.222, 95% CI 1.130–4.371). In addition, the rs1799941 GG genotype and D356 N N allele were associated with lower SHBG in the CHD group (p < 0.01). The logistic regression analysis also revealed the rs1799941 GG genotype was significantly associated with low SHBG in CHD patients. It was observed that Haplotype-1(rs1799941 G allele—P156L P allele—D356 N D allele) was associated with increased CHD risk, while Haplotype-2 (rs1799941 rare A allele-P156L C allele- D356 N G allele) was correlated with the decreased CHD risk (p = 0.0167). Our findings suggest that there is a positive correlation between SHBG and HDL-C levels in CHD patients, and this association might be affected by SHBG gene variations.</description><subject>Adult</subject><subject>Alleles</subject><subject>Animal Anatomy</subject><subject>Animal Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Cardiovascular disease</subject><subject>Case-Control Studies</subject><subject>Chemiluminescence</subject><subject>Cholesterol</subject><subject>Cholesterol, HDL - genetics</subject><subject>Coronary artery disease</subject><subject>coronary disease</subject><subject>Coronary Disease - genetics</subject><subject>electrochemiluminescence</subject><subject>Gene Frequency</subject><subject>Genotype</subject><subject>Globulins</subject><subject>Haplotypes</subject><subject>Health risk assessment</subject><subject>Heart diseases</subject><subject>High density lipoprotein</subject><subject>high density lipoprotein cholesterol</subject><subject>Histology</subject><subject>Humans</subject><subject>immunoassays</subject><subject>Life Sciences</subject><subject>Male</subject><subject>males</subject><subject>Middle Aged</subject><subject>Morphology</subject><subject>Original Article</subject><subject>Polymerase chain reaction</subject><subject>Polymorphism, Single Nucleotide</subject><subject>quantitative polymerase chain reaction</subject><subject>regression analysis</subject><subject>Restriction fragment length polymorphism</subject><subject>risk</subject><subject>Risk Factors</subject><subject>Sex Hormone-Binding Globulin - 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metabolism</topic><topic>Statistical analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kurnaz-Gomleksiz, Ozlem</creatorcontrib><creatorcontrib>Akadam-Teker, Basak</creatorcontrib><creatorcontrib>Bugra, Zehra</creatorcontrib><creatorcontrib>Omer, Beyhan</creatorcontrib><creatorcontrib>Yilmaz-Aydogan, Hulya</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Molecular biology reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kurnaz-Gomleksiz, Ozlem</au><au>Akadam-Teker, Basak</au><au>Bugra, Zehra</au><au>Omer, Beyhan</au><au>Yilmaz-Aydogan, Hulya</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic polymorphisms of the SHBG gene can be the effect on SHBG and HDL-cholesterol levels in Coronary Heart Disease: a case–control study</atitle><jtitle>Molecular biology reports</jtitle><stitle>Mol Biol Rep</stitle><addtitle>Mol Biol Rep</addtitle><date>2019-08-01</date><risdate>2019</risdate><volume>46</volume><issue>4</issue><spage>4259</spage><epage>4269</epage><pages>4259-4269</pages><issn>0301-4851</issn><eissn>1573-4978</eissn><abstract>Sex hormone binding globulin (SHBG) level is positively associated with the high-density lipoprotein cholesterol (HDL-C) levels. The aim of this study was to investigate the effects of the SHBG gene variations (D356N, rs1799941, and P156L) on SHBG and HDL-C levels and Coronary Heart Disease (CHD) risk. The SHBG D356 N (rs6259,G > A), P156L (rs6258,C > T), and rs1799941(G > A) polymorphisms were determined in 131 male CHD patients and 55 male controls by PCR-RFLP and real-time PCR techniques. SHGB levels were measured by Electro-chemiluminescence immunoassay (ECLIA). In the patients who had SHBG levels lower than threshold 35 nmol/l value, the risk of being HDL-C levels lower than threshold 0.90 mmol/l value was observed statistically significant (p = 0.017; OR 2.522, 95% CI 1.170–5.438). The rs1799941 GG was associated with increased CHD risk when compared with the A allele carriers (GA + AA) (p = 0.019, OR 2.222, 95% CI 1.130–4.371). In addition, the rs1799941 GG genotype and D356 N N allele were associated with lower SHBG in the CHD group (p < 0.01). The logistic regression analysis also revealed the rs1799941 GG genotype was significantly associated with low SHBG in CHD patients. It was observed that Haplotype-1(rs1799941 G allele—P156L P allele—D356 N D allele) was associated with increased CHD risk, while Haplotype-2 (rs1799941 rare A allele-P156L C allele- D356 N G allele) was correlated with the decreased CHD risk (p = 0.0167). Our findings suggest that there is a positive correlation between SHBG and HDL-C levels in CHD patients, and this association might be affected by SHBG gene variations.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>31111369</pmid><doi>10.1007/s11033-019-04880-x</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-9904-0146</orcidid><orcidid>https://orcid.org/0000-0001-7938-6281</orcidid><orcidid>https://orcid.org/0000-0003-3618-0560</orcidid><orcidid>https://orcid.org/0000-0001-9827-5253</orcidid><orcidid>https://orcid.org/0000-0002-8837-6664</orcidid></addata></record> |
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| subjects | Adult Alleles Animal Anatomy Animal Biochemistry Biomedical and Life Sciences Cardiovascular disease Case-Control Studies Chemiluminescence Cholesterol Cholesterol, HDL - genetics Coronary artery disease coronary disease Coronary Disease - genetics electrochemiluminescence Gene Frequency Genotype Globulins Haplotypes Health risk assessment Heart diseases High density lipoprotein high density lipoprotein cholesterol Histology Humans immunoassays Life Sciences Male males Middle Aged Morphology Original Article Polymerase chain reaction Polymorphism, Single Nucleotide quantitative polymerase chain reaction regression analysis Restriction fragment length polymorphism risk Risk Factors Sex Hormone-Binding Globulin - genetics Sex Hormone-Binding Globulin - metabolism Statistical analysis |
| title | Genetic polymorphisms of the SHBG gene can be the effect on SHBG and HDL-cholesterol levels in Coronary Heart Disease: a case–control study |
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