Cystatin C improves blood–brain barrier integrity after ischemic brain injury in mice

Cystatin C, a well‐established biomarker of renal function, has been associated with a protective effect against stroke. However, the potential neuroprotective mechanism of cystatin C in ischemic brain injury remains unclear. Our study hypothesized that cystatin C can ameliorate blood–brain barrier...

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Veröffentlicht in:	Journal of neurochemistry 2020-05, Vol.153 (3), p.413-425
Hauptverfasser:	Yang, Bo, Xu, Junjie, Chang, Liuhui, Miao, Zhigang, Heang, Dara, Pu, Yuwei, Zhou, Xun, Zhang, Lingwei, Xie, Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	bEnd.3 Biomarkers Blood-brain barrier Brain injury Caveolin caveolin‐1 Cerebral blood flow Cystatin C Deprivation Disruption Endothelial cells Enzymatic activity Gelatin Head injuries Immunofluorescence Immunohistochemistry Immunoprecipitation Injury prevention Integrity Ischemia ischemic brain injury Matrix metalloproteinases Metalloproteinase Microvasculature Neuroprotection occludin Occlusion Renal function siRNA Stroke Transfection Traumatic brain injury Western blotting
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