In vitro anti-inflammatory properties of Smilax campestris aqueous extract in human macrophages, and characterization of its flavonoid profile

Extracts of Smilax campestris Griseb (Smilacaceae) have been employed in the treatment of several inflammatory diseases as a traditional herbal medicine. However, the cellular and molecular mechanisms involved in the observed effects remain elusive. Macrophages are known to play a central role in in...

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Veröffentlicht in:	Journal of ethnopharmacology 2020-01, Vol.247, p.112282-112282, Article 112282
Hauptverfasser:	Salaverry, Luciana S., Parrado, Andrea C., Mangone, Franco M., Dobrecky, Cecilia B., Flor, Sabrina A., Lombardo, Tomás, Sotelo, Agustina D., Saccodossi, Natalia, Rugna, Ana Z., Blanco, Guillermo, Canellada, Andrea, Rey-Roldán, Estela B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Inflammatory Agents - analysis Anti-Inflammatory Agents - isolation & purification Anti-Inflammatory Agents - pharmacology Argentina Cell Line Cytokines - immunology Cytokines - metabolism Ethnopharmacology Flavonoids Flavonoids - analysis Flavonoids - isolation & purification Flavonoids - pharmacology Glutathione - metabolism Humans Lipopolysaccharides - immunology Macrophages - drug effects Macrophages - immunology Medicine, Traditional - methods Metalloproteinases NF-κB Oxidative Stress - drug effects Plant Extracts - analysis Plant Extracts - isolation & purification Plant Extracts - pharmacology Pro-inflammatory cytokines Smilax - chemistry Smilax campestris aqueous extract Superoxide anion Superoxides - metabolism Toxicity Tests Water - chemistry
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