Trace elements in saliva and plasma of patients with type 2 diabetes: Association to metabolic control and complications
An analysis is made of the saliva and plasma levels of trace elements in patients with type 2 diabetes mellitus and their association to metabolic control and the presence of chronic complications. A cross-sectional observational clinical study was carried out in 74 patients with type 2 diabetes mel...
Gespeichert in:
| Veröffentlicht in: | Diabetes research and clinical practice 2019-11, Vol.157, p.107871-107871, Article 107871 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 107871 |
|---|---|
| container_issue | |
| container_start_page | 107871 |
| container_title | Diabetes research and clinical practice |
| container_volume | 157 |
| creator | Marín-Martínez, Luis Molino-Pagán, Diana López-Jornet, Pía |
| description | An analysis is made of the saliva and plasma levels of trace elements in patients with type 2 diabetes mellitus and their association to metabolic control and the presence of chronic complications.
A cross-sectional observational clinical study was carried out in 74 patients with type 2 diabetes mellitus. Mass spectrometry (ICP-MS) was used to determine the following trace elements in plasma and unstimulated basal saliva: 13Al, 16S, 4Be, 5B, 20Ca, 27Co, 29Cu, 24Cr, 38Sr, 15P, 3Li, 12Mg, 25Mn, 28Ni, 82Pb, 37Rb, 22Ti, 23V and 30Zn.
The levels of cobalt (p = 0.048) in saliva and of strontium (p = 0.001) in plasma were related to the presence of chronic complications. Significant differences with respect to metabolic control were observed for beryllium (p = 0.038), boron (p = 0.023) and phosphorus in saliva (p = 0.046), and for rubidium (p = 0.005), titanium (p = 0.016) and zinc in plasma (p = 0.013). A significant correlation (p |
| doi_str_mv | 10.1016/j.diabres.2019.107871 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2305047716</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0168822719310599</els_id><sourcerecordid>2305047716</sourcerecordid><originalsourceid>FETCH-LOGICAL-c365t-d70e3546c53462e865c6ca594c5af5bb27ff02cf3a1cd466fd9f9bd1bff19a6c3</originalsourceid><addsrcrecordid>eNqFkEtv1DAQgC0EokvhJ4B85LKL7cROwgVVFS-pEpdytpzxWHiVxMHjLfTf433AldOMRt-8PsZeS7GTQpp3-52PbsxIOyXkUGtd38knbCP7Tm17pbqnbFO5_pRfsRdEeyGEaVr9nF010ohW9GrDft9nB8hxwhmXQjwunNwUHxx3i-fr5Gh2PAW-uhJPwK9YfvDyuCJX_HgBFqT3_IYoQaxMWnhJfMbixjRF4JCWktN0mgZpXmvtRNFL9iy4ifDVJV6z758-3t9-2d59-_z19uZuC43RZes7gY1uDeimNQp7o8GA00ML2gU9jqoLQSgIjZPgW2OCH8IwejmGIAdnoLlmb89z15x-HpCKnSMBTpNbMB3IqkZo0XadNBXVZxRyIsoY7Jrj7PKjlcIepdu9vUi3R-n2LL32vbmsOIwz-n9dfy1X4MMZwProQ8RsCapNQB8zQrE-xf-s-ANr2JfH</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2305047716</pqid></control><display><type>article</type><title>Trace elements in saliva and plasma of patients with type 2 diabetes: Association to metabolic control and complications</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Marín-Martínez, Luis ; Molino-Pagán, Diana ; López-Jornet, Pía</creator><creatorcontrib>Marín-Martínez, Luis ; Molino-Pagán, Diana ; López-Jornet, Pía</creatorcontrib><description>An analysis is made of the saliva and plasma levels of trace elements in patients with type 2 diabetes mellitus and their association to metabolic control and the presence of chronic complications.
A cross-sectional observational clinical study was carried out in 74 patients with type 2 diabetes mellitus. Mass spectrometry (ICP-MS) was used to determine the following trace elements in plasma and unstimulated basal saliva: 13Al, 16S, 4Be, 5B, 20Ca, 27Co, 29Cu, 24Cr, 38Sr, 15P, 3Li, 12Mg, 25Mn, 28Ni, 82Pb, 37Rb, 22Ti, 23V and 30Zn.
The levels of cobalt (p = 0.048) in saliva and of strontium (p = 0.001) in plasma were related to the presence of chronic complications. Significant differences with respect to metabolic control were observed for beryllium (p = 0.038), boron (p = 0.023) and phosphorus in saliva (p = 0.046), and for rubidium (p = 0.005), titanium (p = 0.016) and zinc in plasma (p = 0.013). A significant correlation (p < 0.001) was found between boron in plasma and boron in unstimulated basal saliva.
The determination of trace elements in plasma and saliva constitutes a complementary tool for the assessment of metabolic control and for predicting chronic complications associated to type 2 diabetes mellitus. Further studies involving the biomonitoring of trace elements in saliva and plasma are needed.</description><identifier>ISSN: 0168-8227</identifier><identifier>EISSN: 1872-8227</identifier><identifier>DOI: 10.1016/j.diabres.2019.107871</identifier><identifier>PMID: 31604082</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Adult ; Aged ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2 - metabolism ; Female ; Humans ; Male ; Middle Aged ; Plasma ; Plasma - chemistry ; Saliva ; Saliva - chemistry ; Trace elements ; Trace Elements - metabolism ; Type 2 diabetes mellitus</subject><ispartof>Diabetes research and clinical practice, 2019-11, Vol.157, p.107871-107871, Article 107871</ispartof><rights>2019 Elsevier B.V.</rights><rights>Copyright © 2019 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-d70e3546c53462e865c6ca594c5af5bb27ff02cf3a1cd466fd9f9bd1bff19a6c3</citedby><cites>FETCH-LOGICAL-c365t-d70e3546c53462e865c6ca594c5af5bb27ff02cf3a1cd466fd9f9bd1bff19a6c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0168822719310599$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31604082$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Marín-Martínez, Luis</creatorcontrib><creatorcontrib>Molino-Pagán, Diana</creatorcontrib><creatorcontrib>López-Jornet, Pía</creatorcontrib><title>Trace elements in saliva and plasma of patients with type 2 diabetes: Association to metabolic control and complications</title><title>Diabetes research and clinical practice</title><addtitle>Diabetes Res Clin Pract</addtitle><description>An analysis is made of the saliva and plasma levels of trace elements in patients with type 2 diabetes mellitus and their association to metabolic control and the presence of chronic complications.
A cross-sectional observational clinical study was carried out in 74 patients with type 2 diabetes mellitus. Mass spectrometry (ICP-MS) was used to determine the following trace elements in plasma and unstimulated basal saliva: 13Al, 16S, 4Be, 5B, 20Ca, 27Co, 29Cu, 24Cr, 38Sr, 15P, 3Li, 12Mg, 25Mn, 28Ni, 82Pb, 37Rb, 22Ti, 23V and 30Zn.
The levels of cobalt (p = 0.048) in saliva and of strontium (p = 0.001) in plasma were related to the presence of chronic complications. Significant differences with respect to metabolic control were observed for beryllium (p = 0.038), boron (p = 0.023) and phosphorus in saliva (p = 0.046), and for rubidium (p = 0.005), titanium (p = 0.016) and zinc in plasma (p = 0.013). A significant correlation (p < 0.001) was found between boron in plasma and boron in unstimulated basal saliva.
The determination of trace elements in plasma and saliva constitutes a complementary tool for the assessment of metabolic control and for predicting chronic complications associated to type 2 diabetes mellitus. Further studies involving the biomonitoring of trace elements in saliva and plasma are needed.</description><subject>Adult</subject><subject>Aged</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes Mellitus, Type 2 - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Plasma</subject><subject>Plasma - chemistry</subject><subject>Saliva</subject><subject>Saliva - chemistry</subject><subject>Trace elements</subject><subject>Trace Elements - metabolism</subject><subject>Type 2 diabetes mellitus</subject><issn>0168-8227</issn><issn>1872-8227</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtv1DAQgC0EokvhJ4B85LKL7cROwgVVFS-pEpdytpzxWHiVxMHjLfTf433AldOMRt-8PsZeS7GTQpp3-52PbsxIOyXkUGtd38knbCP7Tm17pbqnbFO5_pRfsRdEeyGEaVr9nF010ohW9GrDft9nB8hxwhmXQjwunNwUHxx3i-fr5Gh2PAW-uhJPwK9YfvDyuCJX_HgBFqT3_IYoQaxMWnhJfMbixjRF4JCWktN0mgZpXmvtRNFL9iy4ifDVJV6z758-3t9-2d59-_z19uZuC43RZes7gY1uDeimNQp7o8GA00ML2gU9jqoLQSgIjZPgW2OCH8IwejmGIAdnoLlmb89z15x-HpCKnSMBTpNbMB3IqkZo0XadNBXVZxRyIsoY7Jrj7PKjlcIepdu9vUi3R-n2LL32vbmsOIwz-n9dfy1X4MMZwProQ8RsCapNQB8zQrE-xf-s-ANr2JfH</recordid><startdate>201911</startdate><enddate>201911</enddate><creator>Marín-Martínez, Luis</creator><creator>Molino-Pagán, Diana</creator><creator>López-Jornet, Pía</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201911</creationdate><title>Trace elements in saliva and plasma of patients with type 2 diabetes: Association to metabolic control and complications</title><author>Marín-Martínez, Luis ; Molino-Pagán, Diana ; López-Jornet, Pía</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-d70e3546c53462e865c6ca594c5af5bb27ff02cf3a1cd466fd9f9bd1bff19a6c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes Mellitus, Type 2 - metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Plasma</topic><topic>Plasma - chemistry</topic><topic>Saliva</topic><topic>Saliva - chemistry</topic><topic>Trace elements</topic><topic>Trace Elements - metabolism</topic><topic>Type 2 diabetes mellitus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marín-Martínez, Luis</creatorcontrib><creatorcontrib>Molino-Pagán, Diana</creatorcontrib><creatorcontrib>López-Jornet, Pía</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes research and clinical practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marín-Martínez, Luis</au><au>Molino-Pagán, Diana</au><au>López-Jornet, Pía</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Trace elements in saliva and plasma of patients with type 2 diabetes: Association to metabolic control and complications</atitle><jtitle>Diabetes research and clinical practice</jtitle><addtitle>Diabetes Res Clin Pract</addtitle><date>2019-11</date><risdate>2019</risdate><volume>157</volume><spage>107871</spage><epage>107871</epage><pages>107871-107871</pages><artnum>107871</artnum><issn>0168-8227</issn><eissn>1872-8227</eissn><abstract>An analysis is made of the saliva and plasma levels of trace elements in patients with type 2 diabetes mellitus and their association to metabolic control and the presence of chronic complications.
A cross-sectional observational clinical study was carried out in 74 patients with type 2 diabetes mellitus. Mass spectrometry (ICP-MS) was used to determine the following trace elements in plasma and unstimulated basal saliva: 13Al, 16S, 4Be, 5B, 20Ca, 27Co, 29Cu, 24Cr, 38Sr, 15P, 3Li, 12Mg, 25Mn, 28Ni, 82Pb, 37Rb, 22Ti, 23V and 30Zn.
The levels of cobalt (p = 0.048) in saliva and of strontium (p = 0.001) in plasma were related to the presence of chronic complications. Significant differences with respect to metabolic control were observed for beryllium (p = 0.038), boron (p = 0.023) and phosphorus in saliva (p = 0.046), and for rubidium (p = 0.005), titanium (p = 0.016) and zinc in plasma (p = 0.013). A significant correlation (p < 0.001) was found between boron in plasma and boron in unstimulated basal saliva.
The determination of trace elements in plasma and saliva constitutes a complementary tool for the assessment of metabolic control and for predicting chronic complications associated to type 2 diabetes mellitus. Further studies involving the biomonitoring of trace elements in saliva and plasma are needed.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>31604082</pmid><doi>10.1016/j.diabres.2019.107871</doi><tpages>1</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0168-8227 |
| ispartof | Diabetes research and clinical practice, 2019-11, Vol.157, p.107871-107871, Article 107871 |
| issn | 0168-8227 1872-8227 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2305047716 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adult Aged Cross-Sectional Studies Diabetes Mellitus, Type 2 - metabolism Female Humans Male Middle Aged Plasma Plasma - chemistry Saliva Saliva - chemistry Trace elements Trace Elements - metabolism Type 2 diabetes mellitus |
| title | Trace elements in saliva and plasma of patients with type 2 diabetes: Association to metabolic control and complications |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-12T01%3A05%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Trace%20elements%20in%20saliva%20and%20plasma%20of%20patients%20with%20type%202%20diabetes:%20Association%20to%20metabolic%20control%20and%20complications&rft.jtitle=Diabetes%20research%20and%20clinical%20practice&rft.au=Mar%C3%ADn-Mart%C3%ADnez,%20Luis&rft.date=2019-11&rft.volume=157&rft.spage=107871&rft.epage=107871&rft.pages=107871-107871&rft.artnum=107871&rft.issn=0168-8227&rft.eissn=1872-8227&rft_id=info:doi/10.1016/j.diabres.2019.107871&rft_dat=%3Cproquest_cross%3E2305047716%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2305047716&rft_id=info:pmid/31604082&rft_els_id=S0168822719310599&rfr_iscdi=true |