Neonatal frontal lobe: sonographic reference values and suggested clinical use
Background Intraventricular hemorrhage (IVH) and post-hemorrhagic hydrocephalus (PHHC) remain major problems among premature infants. The need, timing and type of ventricular drainage are based on sonographic ventricular measures, without assessment of the dimensions of the frontal lobe. The aim of...
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| Veröffentlicht in: | Pediatric research 2020-02, Vol.87 (3), p.536-540 |
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| creator | Borenstein-Levin, Liron Makhoul, Shada Ilivitzki, Anat Zreik, Merna Hochwald, Ori Makhoul, Joanne S. Kugelman, Amir Makhoul, Imad R. |
| description | Background
Intraventricular hemorrhage (IVH) and post-hemorrhagic hydrocephalus (PHHC) remain major problems among premature infants. The need, timing and type of ventricular drainage are based on sonographic ventricular measures, without assessment of the dimensions of the frontal lobe. The aim of our study was to establish new reference values for sonographic frontal lobe cortico-ventricular thickness (FL-CVT) in a large cohort of infants.
Methods
All normal head ultrasound scans that were performed in our center during the first 4 days of life between January 2014 and December 2016 were retrospectively evaluated.
Results
Scans were evaluated and plotted to create a reference range for the thickness of the frontal lobe in normal infants of 24–40 weeks’ gestation. The FL-CVT increased significantly during gestation. Calculating the area under the curve of the FL-CVT in 9 infants with post-hemorrhagic-hydrocephalus (PHHC) reveals a 20% mean loss of FL-CVT. The impact of increasing ventricular dilatation and of the various ventricular drainage procedures on the frontal lobe growth were described in two infants demonstrating the potential clinical value of this tool.
Conclusions
Head ultrasound provides a simple, non-invasive method for measuring the thickness of the frontal lobe, which grows significantly between 24 and 40 weeks’ gestation. In premature infants with PHHC, we suggest the use of the FL-CVT measure, in addition to ventricular size measures, as a direct assessment of the impact of the enlarged ventricles on the surrounding brain parenchyma. This could assist in the management of PHHC and determine the need and optimal timing for intervention. |
| doi_str_mv | 10.1038/s41390-019-0605-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2305046733</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2359369571</sourcerecordid><originalsourceid>FETCH-LOGICAL-c415t-467f8418d2008cf59c36ce893a4b46d31c2bcf31ee877ddf6ee1eccafb7b7a0c3</originalsourceid><addsrcrecordid>eNp1kE1LxDAQhoMo7rr6A7xIwYuX6mQnbVpvsvgFy3rRc0jT6dqlm6xJK_jvzbJ-gOBpIHnmnZmHsVMOlxywuAqCYwkp8DKFHLIU99iYZxhfhJD7bAyAPMWyLEbsKIQVABdZIQ7ZCHkOICWO2WJBzuped0njnd3WzlV0nQRn3dLrzWtrEk8NebKGknfdDRQSbeskDMslhZ7qxHStbU3sHAIds4NGd4FOvuqEvdzdPs8e0vnT_ePsZp4awbM-FblsCsGLegpQmCYrDeaGihK1qEReIzfTyjTIiQop67rJiTgZo5tKVlKDwQm72OVuvHuLK_Vq3QZDXactuSGoKUIGcQpiRM__oCs3eBu3i1RWYl5mkkeK7yjjXQjxYrXx7Vr7D8VBbWWrnWwVZautbLVNPvtKHqo11T8d33YjMN0BIX7ZJfnf0f-nfgKodIo4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2359369571</pqid></control><display><type>article</type><title>Neonatal frontal lobe: sonographic reference values and suggested clinical use</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><source>SpringerNature Complete Journals</source><creator>Borenstein-Levin, Liron ; Makhoul, Shada ; Ilivitzki, Anat ; Zreik, Merna ; Hochwald, Ori ; Makhoul, Joanne S. ; Kugelman, Amir ; Makhoul, Imad R.</creator><creatorcontrib>Borenstein-Levin, Liron ; Makhoul, Shada ; Ilivitzki, Anat ; Zreik, Merna ; Hochwald, Ori ; Makhoul, Joanne S. ; Kugelman, Amir ; Makhoul, Imad R.</creatorcontrib><description>Background
Intraventricular hemorrhage (IVH) and post-hemorrhagic hydrocephalus (PHHC) remain major problems among premature infants. The need, timing and type of ventricular drainage are based on sonographic ventricular measures, without assessment of the dimensions of the frontal lobe. The aim of our study was to establish new reference values for sonographic frontal lobe cortico-ventricular thickness (FL-CVT) in a large cohort of infants.
Methods
All normal head ultrasound scans that were performed in our center during the first 4 days of life between January 2014 and December 2016 were retrospectively evaluated.
Results
Scans were evaluated and plotted to create a reference range for the thickness of the frontal lobe in normal infants of 24–40 weeks’ gestation. The FL-CVT increased significantly during gestation. Calculating the area under the curve of the FL-CVT in 9 infants with post-hemorrhagic-hydrocephalus (PHHC) reveals a 20% mean loss of FL-CVT. The impact of increasing ventricular dilatation and of the various ventricular drainage procedures on the frontal lobe growth were described in two infants demonstrating the potential clinical value of this tool.
Conclusions
Head ultrasound provides a simple, non-invasive method for measuring the thickness of the frontal lobe, which grows significantly between 24 and 40 weeks’ gestation. In premature infants with PHHC, we suggest the use of the FL-CVT measure, in addition to ventricular size measures, as a direct assessment of the impact of the enlarged ventricles on the surrounding brain parenchyma. This could assist in the management of PHHC and determine the need and optimal timing for intervention.</description><identifier>ISSN: 0031-3998</identifier><identifier>EISSN: 1530-0447</identifier><identifier>DOI: 10.1038/s41390-019-0605-3</identifier><identifier>PMID: 31600773</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Age Factors ; Cerebral Intraventricular Hemorrhage - complications ; Cerebral Intraventricular Hemorrhage - diagnostic imaging ; Clinical Research Article ; Frontal Lobe - diagnostic imaging ; Humans ; Hydrocephalus - diagnostic imaging ; Hydrocephalus - etiology ; Infant, Newborn ; Medicine ; Medicine & Public Health ; Nomograms ; Pediatric Surgery ; Pediatrics ; Predictive Value of Tests ; Premature birth ; Reference Values ; Retrospective Studies ; Ultrasonic imaging ; Ultrasonography - standards</subject><ispartof>Pediatric research, 2020-02, Vol.87 (3), p.536-540</ispartof><rights>International Pediatric Research Foundation, Inc 2019</rights><rights>2019© International Pediatric Research Foundation, Inc 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-467f8418d2008cf59c36ce893a4b46d31c2bcf31ee877ddf6ee1eccafb7b7a0c3</citedby><cites>FETCH-LOGICAL-c415t-467f8418d2008cf59c36ce893a4b46d31c2bcf31ee877ddf6ee1eccafb7b7a0c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41390-019-0605-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41390-019-0605-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31600773$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Borenstein-Levin, Liron</creatorcontrib><creatorcontrib>Makhoul, Shada</creatorcontrib><creatorcontrib>Ilivitzki, Anat</creatorcontrib><creatorcontrib>Zreik, Merna</creatorcontrib><creatorcontrib>Hochwald, Ori</creatorcontrib><creatorcontrib>Makhoul, Joanne S.</creatorcontrib><creatorcontrib>Kugelman, Amir</creatorcontrib><creatorcontrib>Makhoul, Imad R.</creatorcontrib><title>Neonatal frontal lobe: sonographic reference values and suggested clinical use</title><title>Pediatric research</title><addtitle>Pediatr Res</addtitle><addtitle>Pediatr Res</addtitle><description>Background
Intraventricular hemorrhage (IVH) and post-hemorrhagic hydrocephalus (PHHC) remain major problems among premature infants. The need, timing and type of ventricular drainage are based on sonographic ventricular measures, without assessment of the dimensions of the frontal lobe. The aim of our study was to establish new reference values for sonographic frontal lobe cortico-ventricular thickness (FL-CVT) in a large cohort of infants.
Methods
All normal head ultrasound scans that were performed in our center during the first 4 days of life between January 2014 and December 2016 were retrospectively evaluated.
Results
Scans were evaluated and plotted to create a reference range for the thickness of the frontal lobe in normal infants of 24–40 weeks’ gestation. The FL-CVT increased significantly during gestation. Calculating the area under the curve of the FL-CVT in 9 infants with post-hemorrhagic-hydrocephalus (PHHC) reveals a 20% mean loss of FL-CVT. The impact of increasing ventricular dilatation and of the various ventricular drainage procedures on the frontal lobe growth were described in two infants demonstrating the potential clinical value of this tool.
Conclusions
Head ultrasound provides a simple, non-invasive method for measuring the thickness of the frontal lobe, which grows significantly between 24 and 40 weeks’ gestation. In premature infants with PHHC, we suggest the use of the FL-CVT measure, in addition to ventricular size measures, as a direct assessment of the impact of the enlarged ventricles on the surrounding brain parenchyma. This could assist in the management of PHHC and determine the need and optimal timing for intervention.</description><subject>Age Factors</subject><subject>Cerebral Intraventricular Hemorrhage - complications</subject><subject>Cerebral Intraventricular Hemorrhage - diagnostic imaging</subject><subject>Clinical Research Article</subject><subject>Frontal Lobe - diagnostic imaging</subject><subject>Humans</subject><subject>Hydrocephalus - diagnostic imaging</subject><subject>Hydrocephalus - etiology</subject><subject>Infant, Newborn</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nomograms</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Predictive Value of Tests</subject><subject>Premature birth</subject><subject>Reference Values</subject><subject>Retrospective Studies</subject><subject>Ultrasonic imaging</subject><subject>Ultrasonography - standards</subject><issn>0031-3998</issn><issn>1530-0447</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kE1LxDAQhoMo7rr6A7xIwYuX6mQnbVpvsvgFy3rRc0jT6dqlm6xJK_jvzbJ-gOBpIHnmnZmHsVMOlxywuAqCYwkp8DKFHLIU99iYZxhfhJD7bAyAPMWyLEbsKIQVABdZIQ7ZCHkOICWO2WJBzuped0njnd3WzlV0nQRn3dLrzWtrEk8NebKGknfdDRQSbeskDMslhZ7qxHStbU3sHAIds4NGd4FOvuqEvdzdPs8e0vnT_ePsZp4awbM-FblsCsGLegpQmCYrDeaGihK1qEReIzfTyjTIiQop67rJiTgZo5tKVlKDwQm72OVuvHuLK_Vq3QZDXactuSGoKUIGcQpiRM__oCs3eBu3i1RWYl5mkkeK7yjjXQjxYrXx7Vr7D8VBbWWrnWwVZautbLVNPvtKHqo11T8d33YjMN0BIX7ZJfnf0f-nfgKodIo4</recordid><startdate>20200201</startdate><enddate>20200201</enddate><creator>Borenstein-Levin, Liron</creator><creator>Makhoul, Shada</creator><creator>Ilivitzki, Anat</creator><creator>Zreik, Merna</creator><creator>Hochwald, Ori</creator><creator>Makhoul, Joanne S.</creator><creator>Kugelman, Amir</creator><creator>Makhoul, Imad R.</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20200201</creationdate><title>Neonatal frontal lobe: sonographic reference values and suggested clinical use</title><author>Borenstein-Levin, Liron ; Makhoul, Shada ; Ilivitzki, Anat ; Zreik, Merna ; Hochwald, Ori ; Makhoul, Joanne S. ; Kugelman, Amir ; Makhoul, Imad R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-467f8418d2008cf59c36ce893a4b46d31c2bcf31ee877ddf6ee1eccafb7b7a0c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Age Factors</topic><topic>Cerebral Intraventricular Hemorrhage - complications</topic><topic>Cerebral Intraventricular Hemorrhage - diagnostic imaging</topic><topic>Clinical Research Article</topic><topic>Frontal Lobe - diagnostic imaging</topic><topic>Humans</topic><topic>Hydrocephalus - diagnostic imaging</topic><topic>Hydrocephalus - etiology</topic><topic>Infant, Newborn</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Nomograms</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Predictive Value of Tests</topic><topic>Premature birth</topic><topic>Reference Values</topic><topic>Retrospective Studies</topic><topic>Ultrasonic imaging</topic><topic>Ultrasonography - standards</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Borenstein-Levin, Liron</creatorcontrib><creatorcontrib>Makhoul, Shada</creatorcontrib><creatorcontrib>Ilivitzki, Anat</creatorcontrib><creatorcontrib>Zreik, Merna</creatorcontrib><creatorcontrib>Hochwald, Ori</creatorcontrib><creatorcontrib>Makhoul, Joanne S.</creatorcontrib><creatorcontrib>Kugelman, Amir</creatorcontrib><creatorcontrib>Makhoul, Imad R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Borenstein-Levin, Liron</au><au>Makhoul, Shada</au><au>Ilivitzki, Anat</au><au>Zreik, Merna</au><au>Hochwald, Ori</au><au>Makhoul, Joanne S.</au><au>Kugelman, Amir</au><au>Makhoul, Imad R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neonatal frontal lobe: sonographic reference values and suggested clinical use</atitle><jtitle>Pediatric research</jtitle><stitle>Pediatr Res</stitle><addtitle>Pediatr Res</addtitle><date>2020-02-01</date><risdate>2020</risdate><volume>87</volume><issue>3</issue><spage>536</spage><epage>540</epage><pages>536-540</pages><issn>0031-3998</issn><eissn>1530-0447</eissn><abstract>Background
Intraventricular hemorrhage (IVH) and post-hemorrhagic hydrocephalus (PHHC) remain major problems among premature infants. The need, timing and type of ventricular drainage are based on sonographic ventricular measures, without assessment of the dimensions of the frontal lobe. The aim of our study was to establish new reference values for sonographic frontal lobe cortico-ventricular thickness (FL-CVT) in a large cohort of infants.
Methods
All normal head ultrasound scans that were performed in our center during the first 4 days of life between January 2014 and December 2016 were retrospectively evaluated.
Results
Scans were evaluated and plotted to create a reference range for the thickness of the frontal lobe in normal infants of 24–40 weeks’ gestation. The FL-CVT increased significantly during gestation. Calculating the area under the curve of the FL-CVT in 9 infants with post-hemorrhagic-hydrocephalus (PHHC) reveals a 20% mean loss of FL-CVT. The impact of increasing ventricular dilatation and of the various ventricular drainage procedures on the frontal lobe growth were described in two infants demonstrating the potential clinical value of this tool.
Conclusions
Head ultrasound provides a simple, non-invasive method for measuring the thickness of the frontal lobe, which grows significantly between 24 and 40 weeks’ gestation. In premature infants with PHHC, we suggest the use of the FL-CVT measure, in addition to ventricular size measures, as a direct assessment of the impact of the enlarged ventricles on the surrounding brain parenchyma. This could assist in the management of PHHC and determine the need and optimal timing for intervention.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>31600773</pmid><doi>10.1038/s41390-019-0605-3</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Age Factors Cerebral Intraventricular Hemorrhage - complications Cerebral Intraventricular Hemorrhage - diagnostic imaging Clinical Research Article Frontal Lobe - diagnostic imaging Humans Hydrocephalus - diagnostic imaging Hydrocephalus - etiology Infant, Newborn Medicine Medicine & Public Health Nomograms Pediatric Surgery Pediatrics Predictive Value of Tests Premature birth Reference Values Retrospective Studies Ultrasonic imaging Ultrasonography - standards |
| title | Neonatal frontal lobe: sonographic reference values and suggested clinical use |
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