Discrimination of oral squamous cell carcinoma from oral lichen planus by salivary metabolomics
Objective This study was conducted to distinguish salivary metabolites in oral squamous cell carcinoma (OSCC) from those in oral lichen planus (OLP) to identify practical biomarkers for the discrimination of OSCC from OLP. Subjects and Methods Whole unstimulated saliva samples were collected from pa...
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| Veröffentlicht in: | Oral diseases 2020-01, Vol.26 (1), p.35-42 |
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| creator | Ishikawa, Shigeo Sugimoto, Masahiro Edamatsu, Kaoru Sugano, Ayako Kitabatake, Kenichiro Iino, Mitsuyoshi |
| description | Objective
This study was conducted to distinguish salivary metabolites in oral squamous cell carcinoma (OSCC) from those in oral lichen planus (OLP) to identify practical biomarkers for the discrimination of OSCC from OLP.
Subjects and Methods
Whole unstimulated saliva samples were collected from patients with OSCC (n = 34) and OLP (n = 26). Hydrophilic metabolites in the saliva samples were comprehensively analysed by capillary electrophoresis mass spectrometry. To evaluate the discrimination ability of a combination of multiple markers, a multiple logistic regression (MLR) model was developed to differentiate OSCC from OLP.
Results
Fourteen metabolites were found to be significantly different between the OSCC and OLP groups. Among them, indole‐3‐acetate and ethanolamine phosphate were used to develop the MLR model. The combination of these two metabolites showed a high area under the receiver operating characteristic curve (0.856, 95% confidential interval: 0.762–0.950; p |
| doi_str_mv | 10.1111/odi.13209 |
| format | Article |
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This study was conducted to distinguish salivary metabolites in oral squamous cell carcinoma (OSCC) from those in oral lichen planus (OLP) to identify practical biomarkers for the discrimination of OSCC from OLP.
Subjects and Methods
Whole unstimulated saliva samples were collected from patients with OSCC (n = 34) and OLP (n = 26). Hydrophilic metabolites in the saliva samples were comprehensively analysed by capillary electrophoresis mass spectrometry. To evaluate the discrimination ability of a combination of multiple markers, a multiple logistic regression (MLR) model was developed to differentiate OSCC from OLP.
Results
Fourteen metabolites were found to be significantly different between the OSCC and OLP groups. Among them, indole‐3‐acetate and ethanolamine phosphate were used to develop the MLR model. The combination of these two metabolites showed a high area under the receiver operating characteristic curve (0.856, 95% confidential interval: 0.762–0.950; p < .001) for discriminating OSCC from OLP.
Conclusions
We identified salivary metabolites for discerning between OSCC and OLP, which is clinically important for detecting the malignant transformation of OLP by both dentists and oral surgery specialists. Our candidate salivary metabolites show potential for non‐invasive screening of OSCC versus OLP.</description><identifier>ISSN: 1354-523X</identifier><identifier>EISSN: 1601-0825</identifier><identifier>DOI: 10.1111/odi.13209</identifier><identifier>PMID: 31602722</identifier><language>eng</language><publisher>Denmark: Wiley Subscription Services, Inc</publisher><subject>Acetic acid ; Adult ; Aged ; Aged, 80 and over ; Capillary electrophoresis ; Carcinoma, Squamous Cell - diagnosis ; Dentistry ; Ethanolamine ; Female ; Humans ; Indoles ; Lichen planus ; Lichen Planus, Oral - diagnosis ; Male ; Mass spectroscopy ; Metabolites ; Metabolomics ; Middle Aged ; Mouth Neoplasms - diagnosis ; Oral cancer ; oral lichen planus ; Oral squamous cell carcinoma ; Saliva ; Saliva - metabolism ; screening ; Squamous cell carcinoma ; Surgery</subject><ispartof>Oral diseases, 2020-01, Vol.26 (1), p.35-42</ispartof><rights>2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights reserved</rights><rights>2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights reserved.</rights><rights>Copyright © 2020 John Wiley & Sons A/S</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4199-84157c0bb7e36c5538fad11e3c91144474d59b8c3b0f484476dfc634de66284f3</citedby><cites>FETCH-LOGICAL-c4199-84157c0bb7e36c5538fad11e3c91144474d59b8c3b0f484476dfc634de66284f3</cites><orcidid>0000-0003-3316-2543 ; 0000-0002-1993-0860</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fodi.13209$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fodi.13209$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31602722$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ishikawa, Shigeo</creatorcontrib><creatorcontrib>Sugimoto, Masahiro</creatorcontrib><creatorcontrib>Edamatsu, Kaoru</creatorcontrib><creatorcontrib>Sugano, Ayako</creatorcontrib><creatorcontrib>Kitabatake, Kenichiro</creatorcontrib><creatorcontrib>Iino, Mitsuyoshi</creatorcontrib><title>Discrimination of oral squamous cell carcinoma from oral lichen planus by salivary metabolomics</title><title>Oral diseases</title><addtitle>Oral Dis</addtitle><description>Objective
This study was conducted to distinguish salivary metabolites in oral squamous cell carcinoma (OSCC) from those in oral lichen planus (OLP) to identify practical biomarkers for the discrimination of OSCC from OLP.
Subjects and Methods
Whole unstimulated saliva samples were collected from patients with OSCC (n = 34) and OLP (n = 26). Hydrophilic metabolites in the saliva samples were comprehensively analysed by capillary electrophoresis mass spectrometry. To evaluate the discrimination ability of a combination of multiple markers, a multiple logistic regression (MLR) model was developed to differentiate OSCC from OLP.
Results
Fourteen metabolites were found to be significantly different between the OSCC and OLP groups. Among them, indole‐3‐acetate and ethanolamine phosphate were used to develop the MLR model. The combination of these two metabolites showed a high area under the receiver operating characteristic curve (0.856, 95% confidential interval: 0.762–0.950; p < .001) for discriminating OSCC from OLP.
Conclusions
We identified salivary metabolites for discerning between OSCC and OLP, which is clinically important for detecting the malignant transformation of OLP by both dentists and oral surgery specialists. Our candidate salivary metabolites show potential for non‐invasive screening of OSCC versus OLP.</description><subject>Acetic acid</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Capillary electrophoresis</subject><subject>Carcinoma, Squamous Cell - diagnosis</subject><subject>Dentistry</subject><subject>Ethanolamine</subject><subject>Female</subject><subject>Humans</subject><subject>Indoles</subject><subject>Lichen planus</subject><subject>Lichen Planus, Oral - diagnosis</subject><subject>Male</subject><subject>Mass spectroscopy</subject><subject>Metabolites</subject><subject>Metabolomics</subject><subject>Middle Aged</subject><subject>Mouth Neoplasms - diagnosis</subject><subject>Oral cancer</subject><subject>oral lichen planus</subject><subject>Oral squamous cell carcinoma</subject><subject>Saliva</subject><subject>Saliva - metabolism</subject><subject>screening</subject><subject>Squamous cell carcinoma</subject><subject>Surgery</subject><issn>1354-523X</issn><issn>1601-0825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10MtKAzEUBuAgitbqwheQgBtdTJvb3JbSeikUulFwFzKZDKZkJjXpKH17j051IZhNEvj4OedH6IKSCYUz9bWdUM5IeYBGNCM0IQVLD-HNU5GkjL-coNMY14TQvOTsGJ1wUCxnbITk3EYdbGs7tbW-w77BPiiH41uvWt9HrI1zWKugbedbhZvg20E4q19NhzdOdcCqHY7K2XcVdrg1W1V551ur4xk6apSL5nx_j9Hz_d3T7DFZrh4Ws9tlogUty6QQNM01qarc8EynKS8aVVNquC4pFULkok7LqtC8Io0o4J_Vjc64qE2WsUI0fIyuh9xN8G-9iVvZwmIwu-oMrCEZJykRNC9KoFd_6Nr3oYPpQHHKOCsJBXUzKB18jME0cgM1wXqSEvnVuoTW5XfrYC_3iX3VmvpX_tQMYDqAD-vM7v8kuZovhshPeqaLOA</recordid><startdate>202001</startdate><enddate>202001</enddate><creator>Ishikawa, Shigeo</creator><creator>Sugimoto, Masahiro</creator><creator>Edamatsu, Kaoru</creator><creator>Sugano, Ayako</creator><creator>Kitabatake, Kenichiro</creator><creator>Iino, Mitsuyoshi</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3316-2543</orcidid><orcidid>https://orcid.org/0000-0002-1993-0860</orcidid></search><sort><creationdate>202001</creationdate><title>Discrimination of oral squamous cell carcinoma from oral lichen planus by salivary metabolomics</title><author>Ishikawa, Shigeo ; Sugimoto, Masahiro ; Edamatsu, Kaoru ; Sugano, Ayako ; Kitabatake, Kenichiro ; Iino, Mitsuyoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4199-84157c0bb7e36c5538fad11e3c91144474d59b8c3b0f484476dfc634de66284f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Acetic acid</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Capillary electrophoresis</topic><topic>Carcinoma, Squamous Cell - diagnosis</topic><topic>Dentistry</topic><topic>Ethanolamine</topic><topic>Female</topic><topic>Humans</topic><topic>Indoles</topic><topic>Lichen planus</topic><topic>Lichen Planus, Oral - diagnosis</topic><topic>Male</topic><topic>Mass spectroscopy</topic><topic>Metabolites</topic><topic>Metabolomics</topic><topic>Middle Aged</topic><topic>Mouth Neoplasms - diagnosis</topic><topic>Oral cancer</topic><topic>oral lichen planus</topic><topic>Oral squamous cell carcinoma</topic><topic>Saliva</topic><topic>Saliva - metabolism</topic><topic>screening</topic><topic>Squamous cell carcinoma</topic><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ishikawa, Shigeo</creatorcontrib><creatorcontrib>Sugimoto, Masahiro</creatorcontrib><creatorcontrib>Edamatsu, Kaoru</creatorcontrib><creatorcontrib>Sugano, Ayako</creatorcontrib><creatorcontrib>Kitabatake, Kenichiro</creatorcontrib><creatorcontrib>Iino, Mitsuyoshi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Oral diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ishikawa, Shigeo</au><au>Sugimoto, Masahiro</au><au>Edamatsu, Kaoru</au><au>Sugano, Ayako</au><au>Kitabatake, Kenichiro</au><au>Iino, Mitsuyoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Discrimination of oral squamous cell carcinoma from oral lichen planus by salivary metabolomics</atitle><jtitle>Oral diseases</jtitle><addtitle>Oral Dis</addtitle><date>2020-01</date><risdate>2020</risdate><volume>26</volume><issue>1</issue><spage>35</spage><epage>42</epage><pages>35-42</pages><issn>1354-523X</issn><eissn>1601-0825</eissn><abstract>Objective
This study was conducted to distinguish salivary metabolites in oral squamous cell carcinoma (OSCC) from those in oral lichen planus (OLP) to identify practical biomarkers for the discrimination of OSCC from OLP.
Subjects and Methods
Whole unstimulated saliva samples were collected from patients with OSCC (n = 34) and OLP (n = 26). Hydrophilic metabolites in the saliva samples were comprehensively analysed by capillary electrophoresis mass spectrometry. To evaluate the discrimination ability of a combination of multiple markers, a multiple logistic regression (MLR) model was developed to differentiate OSCC from OLP.
Results
Fourteen metabolites were found to be significantly different between the OSCC and OLP groups. Among them, indole‐3‐acetate and ethanolamine phosphate were used to develop the MLR model. The combination of these two metabolites showed a high area under the receiver operating characteristic curve (0.856, 95% confidential interval: 0.762–0.950; p < .001) for discriminating OSCC from OLP.
Conclusions
We identified salivary metabolites for discerning between OSCC and OLP, which is clinically important for detecting the malignant transformation of OLP by both dentists and oral surgery specialists. Our candidate salivary metabolites show potential for non‐invasive screening of OSCC versus OLP.</abstract><cop>Denmark</cop><pub>Wiley Subscription Services, Inc</pub><pmid>31602722</pmid><doi>10.1111/odi.13209</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-3316-2543</orcidid><orcidid>https://orcid.org/0000-0002-1993-0860</orcidid></addata></record> |
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| ispartof | Oral diseases, 2020-01, Vol.26 (1), p.35-42 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Acetic acid Adult Aged Aged, 80 and over Capillary electrophoresis Carcinoma, Squamous Cell - diagnosis Dentistry Ethanolamine Female Humans Indoles Lichen planus Lichen Planus, Oral - diagnosis Male Mass spectroscopy Metabolites Metabolomics Middle Aged Mouth Neoplasms - diagnosis Oral cancer oral lichen planus Oral squamous cell carcinoma Saliva Saliva - metabolism screening Squamous cell carcinoma Surgery |
| title | Discrimination of oral squamous cell carcinoma from oral lichen planus by salivary metabolomics |
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