Sperm DNA fragmentation: causes and identification

Sperm DNA fragmentation is referred to as one of the main causes of male infertility. Failures in the protamination process, apoptosis and action of reactive oxygen species (ROS) are considered the most important causes of DNA fragmentation. Action of ROS or changes in sperm protamination would incr...

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Veröffentlicht in:	Zygote (Cambridge) 2020-02, Vol.28 (1), p.1-8
Hauptverfasser:	Hamilton, Thais Rose Dos Santos, Assumpção, Mayra Elena Ortiz D'Ávila
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Bioassays Chromatin Comet assay Damage detection Deoxyribonucleic acid DNA DNA damage DNA fragmentation DNA repair Embryos Enzymes Evaluation Fertility Fragmentation Infertility Integrity Labeling Mammals Oxidative stress Physiology Protamine Proteins Reactive oxygen species Semen Sperm Spermatogenesis Stability analysis Toluidine Toluidine blue Toxicity Zebrafish
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