A mutant KRAS‐induced factor REG4 promotes cancer stem cell properties via Wnt/β‐catenin signaling

Mutant KRAS provides a driving force for enhancement of cancer stem cells (CSCs) characteristics contributing transformation of colorectal cancer (CRC) cells harboring adenomatous polyposis coli (APC) mutations. Here, we identified the factors mediating the promotion of CSCs properties induced by KR...

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Veröffentlicht in:	International journal of cancer 2020-05, Vol.146 (10), p.2877-2890
Hauptverfasser:	Hwang, Jeong‐Ha, Yoon, Junyong, Cho, Yong‐Hee, Cha, Pu‐Hyeon, Park, Jong‐Chan, Choi, Kang‐Yell
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenomatous polyposis coli APC mutation Cancer cancer stem cells Catenin Colon Colorectal cancer Colorectal carcinoma CRISPR Intestine K-Ras protein KRAS mutation Medical research Mutants Mutation Organoids Polyposis coli REG4 Spheroids Stem cell transplantation Stem cells Tumors Wnt protein Wnt/β‐catenin signaling Xenografts
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