Epidemiological Data and Treatment of Gastroenteropancreatic Neuroendocrine Neoplasms: Insights From Tertiary Referral Hospitals in Latvia
Background Gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN) are rare, heterogeneous group which tend to rise in incidence. Epidemiological profile and outcomes of GEP-NEN may vary among countries. The aim of study was to provide baseline clinical and histopathological features of patients w...
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| Veröffentlicht in: | World journal of surgery 2020-02, Vol.44 (2), p.585-593 |
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| creator | Ptasnuka, Margarita Ozolins, Arturs Narbuts, Zenons Truskovs, Arturs Sperga, Maris Plaudis, Haralds |
| description | Background
Gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN) are rare, heterogeneous group which tend to rise in incidence. Epidemiological profile and outcomes of GEP-NEN may vary among countries. The aim of study was to provide baseline clinical and histopathological features of patients with GEP-NEN from tertiary referral hospitals in Latvia.
Methods
A retrospective study of patients with histologically confirmed diagnosis of GEP-NEN treated between 2006 and 2018. Joinpoint regression modeling was used to estimate annual percentage change (APC) for incidence trends. Overall survival (OS) rate was obtained by Kaplan–Meier method.
Results
In total, 205 patients were included. The median age at diagnosis was 61.0 (IQR 52.0–70.5) years, 69.3% were females. The age-adjusted incidence per 100 000 inhabitants increased from 0.03 in 2006 to 0.67 in 2018 with APC of 24.1%,
p |
| doi_str_mv | 10.1007/s00268-019-05219-0 |
| format | Article |
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Gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN) are rare, heterogeneous group which tend to rise in incidence. Epidemiological profile and outcomes of GEP-NEN may vary among countries. The aim of study was to provide baseline clinical and histopathological features of patients with GEP-NEN from tertiary referral hospitals in Latvia.
Methods
A retrospective study of patients with histologically confirmed diagnosis of GEP-NEN treated between 2006 and 2018. Joinpoint regression modeling was used to estimate annual percentage change (APC) for incidence trends. Overall survival (OS) rate was obtained by Kaplan–Meier method.
Results
In total, 205 patients were included. The median age at diagnosis was 61.0 (IQR 52.0–70.5) years, 69.3% were females. The age-adjusted incidence per 100 000 inhabitants increased from 0.03 in 2006 to 0.67 in 2018 with APC of 24.1%,
p
< 0.005. The most common primary tumor site was pancreas (30.7%), followed by stomach (24.9%) and small intestine (20.5%). Non-functional tumors are present in 83.4%, while carcinoid syndrome in 7.8%. Stage IV metastatic disease was present in 27.8% tumors. The majority of patients (82%) received an operation with radical or palliative intent. The 1- and 3-year OS rate were 88.0% (95% CI 83.3–92.7) and 77.1% (95% CI 70.4–83.8), respectively. Increasing tumor grade, stage and the presence of distant metastases were associated with significantly worse OS.
Conclusion
Our study highlights increasing incidence of GEP-NEN in Latvia. The most common primary site was pancreas and surgery considered as main modality of treatment. Registry and long-term data collection are necessary to develop GEP-NEN management concept in Latvia.</description><identifier>ISSN: 0364-2313</identifier><identifier>EISSN: 1432-2323</identifier><identifier>DOI: 10.1007/s00268-019-05219-0</identifier><identifier>PMID: 31605174</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Abdominal Surgery ; Adenomatous polyposis coli ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Cardiac Surgery ; Data collection ; Diagnosis ; Epidemiology ; Female ; Females ; General Surgery ; Hospitals ; Humans ; Incidence ; Intestinal Neoplasms - epidemiology ; Intestinal Neoplasms - mortality ; Intestinal Neoplasms - pathology ; Intestinal Neoplasms - therapy ; Intestine ; Male ; Medicine ; Medicine & Public Health ; Metastases ; Middle Aged ; Neoplasm Grading ; Neoplasms ; Neuroendocrine tumors ; Neuroendocrine Tumors - epidemiology ; Neuroendocrine Tumors - mortality ; Neuroendocrine Tumors - pathology ; Neuroendocrine Tumors - therapy ; Original Scientific Report ; Pancreas ; Pancreatic Neoplasms - epidemiology ; Pancreatic Neoplasms - mortality ; Pancreatic Neoplasms - pathology ; Pancreatic Neoplasms - therapy ; Patients ; Retrospective Studies ; Small intestine ; Stomach Neoplasms - epidemiology ; Stomach Neoplasms - mortality ; Stomach Neoplasms - pathology ; Stomach Neoplasms - therapy ; Surgery ; Tertiary Care Centers ; Thoracic Surgery ; Tumors ; Vascular Surgery ; Young Adult</subject><ispartof>World journal of surgery, 2020-02, Vol.44 (2), p.585-593</ispartof><rights>Société Internationale de Chirurgie 2019</rights><rights>2020 The Author(s) under exclusive licence to Société Internationale de Chirurgie</rights><rights>World Journal of Surgery is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4269-58531fc71967eac1de7d063547f4edf83f0d58c559ad813001a7158bb9e4517d3</citedby><cites>FETCH-LOGICAL-c4269-58531fc71967eac1de7d063547f4edf83f0d58c559ad813001a7158bb9e4517d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00268-019-05219-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00268-019-05219-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,41488,42557,45574,45575,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31605174$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ptasnuka, Margarita</creatorcontrib><creatorcontrib>Ozolins, Arturs</creatorcontrib><creatorcontrib>Narbuts, Zenons</creatorcontrib><creatorcontrib>Truskovs, Arturs</creatorcontrib><creatorcontrib>Sperga, Maris</creatorcontrib><creatorcontrib>Plaudis, Haralds</creatorcontrib><title>Epidemiological Data and Treatment of Gastroenteropancreatic Neuroendocrine Neoplasms: Insights From Tertiary Referral Hospitals in Latvia</title><title>World journal of surgery</title><addtitle>World J Surg</addtitle><addtitle>World J Surg</addtitle><description>Background
Gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN) are rare, heterogeneous group which tend to rise in incidence. Epidemiological profile and outcomes of GEP-NEN may vary among countries. The aim of study was to provide baseline clinical and histopathological features of patients with GEP-NEN from tertiary referral hospitals in Latvia.
Methods
A retrospective study of patients with histologically confirmed diagnosis of GEP-NEN treated between 2006 and 2018. Joinpoint regression modeling was used to estimate annual percentage change (APC) for incidence trends. Overall survival (OS) rate was obtained by Kaplan–Meier method.
Results
In total, 205 patients were included. The median age at diagnosis was 61.0 (IQR 52.0–70.5) years, 69.3% were females. The age-adjusted incidence per 100 000 inhabitants increased from 0.03 in 2006 to 0.67 in 2018 with APC of 24.1%,
p
< 0.005. The most common primary tumor site was pancreas (30.7%), followed by stomach (24.9%) and small intestine (20.5%). Non-functional tumors are present in 83.4%, while carcinoid syndrome in 7.8%. Stage IV metastatic disease was present in 27.8% tumors. The majority of patients (82%) received an operation with radical or palliative intent. The 1- and 3-year OS rate were 88.0% (95% CI 83.3–92.7) and 77.1% (95% CI 70.4–83.8), respectively. Increasing tumor grade, stage and the presence of distant metastases were associated with significantly worse OS.
Conclusion
Our study highlights increasing incidence of GEP-NEN in Latvia. The most common primary site was pancreas and surgery considered as main modality of treatment. Registry and long-term data collection are necessary to develop GEP-NEN management concept in Latvia.</description><subject>Abdominal Surgery</subject><subject>Adenomatous polyposis coli</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cardiac Surgery</subject><subject>Data collection</subject><subject>Diagnosis</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Females</subject><subject>General Surgery</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Incidence</subject><subject>Intestinal Neoplasms - epidemiology</subject><subject>Intestinal Neoplasms - mortality</subject><subject>Intestinal Neoplasms - pathology</subject><subject>Intestinal Neoplasms - therapy</subject><subject>Intestine</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metastases</subject><subject>Middle Aged</subject><subject>Neoplasm Grading</subject><subject>Neoplasms</subject><subject>Neuroendocrine tumors</subject><subject>Neuroendocrine Tumors - epidemiology</subject><subject>Neuroendocrine Tumors - mortality</subject><subject>Neuroendocrine Tumors - pathology</subject><subject>Neuroendocrine Tumors - therapy</subject><subject>Original Scientific Report</subject><subject>Pancreas</subject><subject>Pancreatic Neoplasms - epidemiology</subject><subject>Pancreatic Neoplasms - mortality</subject><subject>Pancreatic Neoplasms - pathology</subject><subject>Pancreatic Neoplasms - therapy</subject><subject>Patients</subject><subject>Retrospective Studies</subject><subject>Small intestine</subject><subject>Stomach Neoplasms - epidemiology</subject><subject>Stomach Neoplasms - mortality</subject><subject>Stomach Neoplasms - pathology</subject><subject>Stomach Neoplasms - therapy</subject><subject>Surgery</subject><subject>Tertiary Care Centers</subject><subject>Thoracic Surgery</subject><subject>Tumors</subject><subject>Vascular Surgery</subject><subject>Young Adult</subject><issn>0364-2313</issn><issn>1432-2323</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkc1u1DAUhS0EotPCC7BAltiwCdhxHCfdQem0RSOQYBBLy2PfDK4SO9gJqK_Qp-YOKSCxQGz8c_2d63N1CHnC2QvOmHqZGSvrpmC8LZgsD-s9suKVKItSlOI-WTFRV3jm4ogc53zNGFc1qx-SI8FrJrmqVuT2fPQOBh_7uPfW9PSNmQw1wdFtAjMNECYaO3ph8pQiXiDF0QR7ePOWvoP5UHXRJh8Ar3HsTR7yKb0K2e-_TJmuUxzoFtLkTbqhH6CDlPCby5hHP5k-Ux_oxkzfvHlEHnRYgMd3-wn5tD7fnl0Wm_cXV2evNoWtyrotZCMF76ziba3AWO5AOVYLWamuAtc1omNONlbK1riGCxzaKC6b3a6FCmd24oQ8X_qOKX6dIU968NlC35sAcc66FEyyshVKIPrsL_Q6zimgO6Qq0aIhrpAqF8qmmHOCTo_JDziu5kwfktJLUhqT0j-T0gxFT-9az7sB3G_Jr2gQOF2A776Hm_9oqT-__fh6jeWqRbFYxBl1YQ_pj_F_ePoBTyCw1g</recordid><startdate>202002</startdate><enddate>202002</enddate><creator>Ptasnuka, Margarita</creator><creator>Ozolins, Arturs</creator><creator>Narbuts, Zenons</creator><creator>Truskovs, Arturs</creator><creator>Sperga, Maris</creator><creator>Plaudis, Haralds</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>202002</creationdate><title>Epidemiological Data and Treatment of Gastroenteropancreatic Neuroendocrine Neoplasms: Insights From Tertiary Referral Hospitals in Latvia</title><author>Ptasnuka, Margarita ; Ozolins, Arturs ; Narbuts, Zenons ; Truskovs, Arturs ; Sperga, Maris ; Plaudis, Haralds</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4269-58531fc71967eac1de7d063547f4edf83f0d58c559ad813001a7158bb9e4517d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Abdominal Surgery</topic><topic>Adenomatous polyposis coli</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cardiac Surgery</topic><topic>Data collection</topic><topic>Diagnosis</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Females</topic><topic>General Surgery</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Incidence</topic><topic>Intestinal Neoplasms - epidemiology</topic><topic>Intestinal Neoplasms - mortality</topic><topic>Intestinal Neoplasms - pathology</topic><topic>Intestinal Neoplasms - therapy</topic><topic>Intestine</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metastases</topic><topic>Middle Aged</topic><topic>Neoplasm Grading</topic><topic>Neoplasms</topic><topic>Neuroendocrine tumors</topic><topic>Neuroendocrine Tumors - epidemiology</topic><topic>Neuroendocrine Tumors - mortality</topic><topic>Neuroendocrine Tumors - pathology</topic><topic>Neuroendocrine Tumors - therapy</topic><topic>Original Scientific Report</topic><topic>Pancreas</topic><topic>Pancreatic Neoplasms - epidemiology</topic><topic>Pancreatic Neoplasms - mortality</topic><topic>Pancreatic Neoplasms - pathology</topic><topic>Pancreatic Neoplasms - therapy</topic><topic>Patients</topic><topic>Retrospective Studies</topic><topic>Small intestine</topic><topic>Stomach Neoplasms - epidemiology</topic><topic>Stomach Neoplasms - mortality</topic><topic>Stomach Neoplasms - pathology</topic><topic>Stomach Neoplasms - therapy</topic><topic>Surgery</topic><topic>Tertiary Care Centers</topic><topic>Thoracic Surgery</topic><topic>Tumors</topic><topic>Vascular Surgery</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ptasnuka, Margarita</creatorcontrib><creatorcontrib>Ozolins, Arturs</creatorcontrib><creatorcontrib>Narbuts, Zenons</creatorcontrib><creatorcontrib>Truskovs, Arturs</creatorcontrib><creatorcontrib>Sperga, Maris</creatorcontrib><creatorcontrib>Plaudis, Haralds</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>World journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ptasnuka, Margarita</au><au>Ozolins, Arturs</au><au>Narbuts, Zenons</au><au>Truskovs, Arturs</au><au>Sperga, Maris</au><au>Plaudis, Haralds</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epidemiological Data and Treatment of Gastroenteropancreatic Neuroendocrine Neoplasms: Insights From Tertiary Referral Hospitals in Latvia</atitle><jtitle>World journal of surgery</jtitle><stitle>World J Surg</stitle><addtitle>World J Surg</addtitle><date>2020-02</date><risdate>2020</risdate><volume>44</volume><issue>2</issue><spage>585</spage><epage>593</epage><pages>585-593</pages><issn>0364-2313</issn><eissn>1432-2323</eissn><abstract>Background
Gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN) are rare, heterogeneous group which tend to rise in incidence. Epidemiological profile and outcomes of GEP-NEN may vary among countries. The aim of study was to provide baseline clinical and histopathological features of patients with GEP-NEN from tertiary referral hospitals in Latvia.
Methods
A retrospective study of patients with histologically confirmed diagnosis of GEP-NEN treated between 2006 and 2018. Joinpoint regression modeling was used to estimate annual percentage change (APC) for incidence trends. Overall survival (OS) rate was obtained by Kaplan–Meier method.
Results
In total, 205 patients were included. The median age at diagnosis was 61.0 (IQR 52.0–70.5) years, 69.3% were females. The age-adjusted incidence per 100 000 inhabitants increased from 0.03 in 2006 to 0.67 in 2018 with APC of 24.1%,
p
< 0.005. The most common primary tumor site was pancreas (30.7%), followed by stomach (24.9%) and small intestine (20.5%). Non-functional tumors are present in 83.4%, while carcinoid syndrome in 7.8%. Stage IV metastatic disease was present in 27.8% tumors. The majority of patients (82%) received an operation with radical or palliative intent. The 1- and 3-year OS rate were 88.0% (95% CI 83.3–92.7) and 77.1% (95% CI 70.4–83.8), respectively. Increasing tumor grade, stage and the presence of distant metastases were associated with significantly worse OS.
Conclusion
Our study highlights increasing incidence of GEP-NEN in Latvia. The most common primary site was pancreas and surgery considered as main modality of treatment. Registry and long-term data collection are necessary to develop GEP-NEN management concept in Latvia.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>31605174</pmid><doi>10.1007/s00268-019-05219-0</doi><tpages>9</tpages></addata></record> |
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| ispartof | World journal of surgery, 2020-02, Vol.44 (2), p.585-593 |
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| subjects | Abdominal Surgery Adenomatous polyposis coli Adolescent Adult Aged Aged, 80 and over Cardiac Surgery Data collection Diagnosis Epidemiology Female Females General Surgery Hospitals Humans Incidence Intestinal Neoplasms - epidemiology Intestinal Neoplasms - mortality Intestinal Neoplasms - pathology Intestinal Neoplasms - therapy Intestine Male Medicine Medicine & Public Health Metastases Middle Aged Neoplasm Grading Neoplasms Neuroendocrine tumors Neuroendocrine Tumors - epidemiology Neuroendocrine Tumors - mortality Neuroendocrine Tumors - pathology Neuroendocrine Tumors - therapy Original Scientific Report Pancreas Pancreatic Neoplasms - epidemiology Pancreatic Neoplasms - mortality Pancreatic Neoplasms - pathology Pancreatic Neoplasms - therapy Patients Retrospective Studies Small intestine Stomach Neoplasms - epidemiology Stomach Neoplasms - mortality Stomach Neoplasms - pathology Stomach Neoplasms - therapy Surgery Tertiary Care Centers Thoracic Surgery Tumors Vascular Surgery Young Adult |
| title | Epidemiological Data and Treatment of Gastroenteropancreatic Neuroendocrine Neoplasms: Insights From Tertiary Referral Hospitals in Latvia |
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