Selective distribution of GLUT3-expressing nerve fibers in the lamina terminalis among the circumventricular organs of mice
Sensory circumventricular organs contain the subfornical organ, organum vasculosum of the lamina terminalis (OVLT), and area postrema. Here, immunostaining for GLUT3 in the murine brain selectively labeled the sobfornical organ and OVLT. The immunoreactive neural tract of the subfornical organ forme...
Gespeichert in:
| Veröffentlicht in: | Biomedical Research 2019/10/01, Vol.40(5), pp.207-214 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 214 |
|---|---|
| container_issue | 5 |
| container_start_page | 207 |
| container_title | Biomedical Research |
| container_volume | 40 |
| creator | IWANAGA, Toshihiko KONNO, Kohtarou WATANABE, Masahiko |
| description | Sensory circumventricular organs contain the subfornical organ, organum vasculosum of the lamina terminalis (OVLT), and area postrema. Here, immunostaining for GLUT3 in the murine brain selectively labeled the sobfornical organ and OVLT. The immunoreactive neural tract of the subfornical organ formed into thin bundles and extended ventro-rostrally over the anterior commissure. After turning over the commissure, the neural tract passed through the median preoptic nucleus (MnPO) and reached the OVLT; thus, a continuous neural tract expressing GLUT3 connected the subfornical organ, MnPO, and OVLT in the lamina terminalis. In the OVLT, GLUT3-immunoreactive fibers gathered in both the dorsal cap and lateral periventricular zone. Electron microscopically, the immunoreactive structures in the subfornical organ corresponded to nerve fibers or nerve terminals containing many small clear vesicles. The area postrema, another sensory organ, was immunonegative for GLUT3. This study not only presented a useful marker tracing the neural tract in the sensory sites of the lamina terminalis but also suggested a unique system for sensing and determining the metabolism of circulating glucose in the circumventricular organs. |
| doi_str_mv | 10.2220/biomedres.40.207 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2303750633</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2303750633</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5357-3cabc4ae9f0edad4b8dd8f50e2f5e377f98231d2f66d4abd17643f31fe39fa9a3</originalsourceid><addsrcrecordid>eNpdkcGL1DAUh4Mo7uzq3ZMEvHjpmvS1TXuUQdeFAQ_ugrfymrzMZmiTMWmXFf95M844oKdH3u97H4QfY2-kuC7LUnwYXJjIRErXVd4I9YytZNuKAiR8f85WAtq2aKRQF-wypZ3Ib9nCS3YBsu5UJ5oV-_WNRtKzeyRuXJqjG5bZBc-D5Teb-zso6Gmf_cn5LfcUM2bdQDFx5_n8QHzEyXnkM8XDHF3iOIXMHjLtol6mR_JZq5cRIw9xiz4d5JPT9Iq9sDgmen2aV-z-86e79Zdi8_Xmdv1xU-gaalWAxkFXSJ0VZNBUQ2tMa2tBpa0JlLJdW4I0pW0aU-FgpGoqsCAtQWexQ7hi74_efQw_FkpzP7mkaRzRU1hSX4IAVYsGIKPv_kN3YYn5Y3-oDkpRQZMpcaR0DClFsv0-ugnjz16K_lBMfy6mr_JGqHzy9iRehpycD_42kYH1EdilGbd0BjDOTo_0r7E-ac-pfsDYk4ffivGnJQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2309320436</pqid></control><display><type>article</type><title>Selective distribution of GLUT3-expressing nerve fibers in the lamina terminalis among the circumventricular organs of mice</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese</source><creator>IWANAGA, Toshihiko ; KONNO, Kohtarou ; WATANABE, Masahiko</creator><creatorcontrib>IWANAGA, Toshihiko ; KONNO, Kohtarou ; WATANABE, Masahiko</creatorcontrib><description>Sensory circumventricular organs contain the subfornical organ, organum vasculosum of the lamina terminalis (OVLT), and area postrema. Here, immunostaining for GLUT3 in the murine brain selectively labeled the sobfornical organ and OVLT. The immunoreactive neural tract of the subfornical organ formed into thin bundles and extended ventro-rostrally over the anterior commissure. After turning over the commissure, the neural tract passed through the median preoptic nucleus (MnPO) and reached the OVLT; thus, a continuous neural tract expressing GLUT3 connected the subfornical organ, MnPO, and OVLT in the lamina terminalis. In the OVLT, GLUT3-immunoreactive fibers gathered in both the dorsal cap and lateral periventricular zone. Electron microscopically, the immunoreactive structures in the subfornical organ corresponded to nerve fibers or nerve terminals containing many small clear vesicles. The area postrema, another sensory organ, was immunonegative for GLUT3. This study not only presented a useful marker tracing the neural tract in the sensory sites of the lamina terminalis but also suggested a unique system for sensing and determining the metabolism of circulating glucose in the circumventricular organs.</description><identifier>ISSN: 0388-6107</identifier><identifier>EISSN: 1880-313X</identifier><identifier>DOI: 10.2220/biomedres.40.207</identifier><identifier>PMID: 31597906</identifier><language>eng</language><publisher>Japan: Biomedical Research Press</publisher><subject>Animals ; Anterior commissure ; Area postrema ; Biomarkers ; Circumventricular Organs - metabolism ; Disease Models, Animal ; Female ; Fibers ; Fluorescent Antibody Technique ; Gene Expression ; Glucose metabolism ; Glucose Transporter Type 3 - genetics ; Hypothalamus - metabolism ; Immunohistochemistry ; Male ; Mice ; Nerve endings ; Nerve Fibers - metabolism ; Organs ; Osmosis ; Preoptic area (medial) ; Rodents ; Sense organs ; Subfornical organ</subject><ispartof>Biomedical Research, 2019/10/01, Vol.40(5), pp.207-214</ispartof><rights>2019 Biomedical Research Press</rights><rights>Copyright Japan Science and Technology Agency 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5357-3cabc4ae9f0edad4b8dd8f50e2f5e377f98231d2f66d4abd17643f31fe39fa9a3</citedby><cites>FETCH-LOGICAL-c5357-3cabc4ae9f0edad4b8dd8f50e2f5e377f98231d2f66d4abd17643f31fe39fa9a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1881,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31597906$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>IWANAGA, Toshihiko</creatorcontrib><creatorcontrib>KONNO, Kohtarou</creatorcontrib><creatorcontrib>WATANABE, Masahiko</creatorcontrib><title>Selective distribution of GLUT3-expressing nerve fibers in the lamina terminalis among the circumventricular organs of mice</title><title>Biomedical Research</title><addtitle>Biomed. Res.</addtitle><description>Sensory circumventricular organs contain the subfornical organ, organum vasculosum of the lamina terminalis (OVLT), and area postrema. Here, immunostaining for GLUT3 in the murine brain selectively labeled the sobfornical organ and OVLT. The immunoreactive neural tract of the subfornical organ formed into thin bundles and extended ventro-rostrally over the anterior commissure. After turning over the commissure, the neural tract passed through the median preoptic nucleus (MnPO) and reached the OVLT; thus, a continuous neural tract expressing GLUT3 connected the subfornical organ, MnPO, and OVLT in the lamina terminalis. In the OVLT, GLUT3-immunoreactive fibers gathered in both the dorsal cap and lateral periventricular zone. Electron microscopically, the immunoreactive structures in the subfornical organ corresponded to nerve fibers or nerve terminals containing many small clear vesicles. The area postrema, another sensory organ, was immunonegative for GLUT3. This study not only presented a useful marker tracing the neural tract in the sensory sites of the lamina terminalis but also suggested a unique system for sensing and determining the metabolism of circulating glucose in the circumventricular organs.</description><subject>Animals</subject><subject>Anterior commissure</subject><subject>Area postrema</subject><subject>Biomarkers</subject><subject>Circumventricular Organs - metabolism</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>Fibers</subject><subject>Fluorescent Antibody Technique</subject><subject>Gene Expression</subject><subject>Glucose metabolism</subject><subject>Glucose Transporter Type 3 - genetics</subject><subject>Hypothalamus - metabolism</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Mice</subject><subject>Nerve endings</subject><subject>Nerve Fibers - metabolism</subject><subject>Organs</subject><subject>Osmosis</subject><subject>Preoptic area (medial)</subject><subject>Rodents</subject><subject>Sense organs</subject><subject>Subfornical organ</subject><issn>0388-6107</issn><issn>1880-313X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkcGL1DAUh4Mo7uzq3ZMEvHjpmvS1TXuUQdeFAQ_ugrfymrzMZmiTMWmXFf95M844oKdH3u97H4QfY2-kuC7LUnwYXJjIRErXVd4I9YytZNuKAiR8f85WAtq2aKRQF-wypZ3Ib9nCS3YBsu5UJ5oV-_WNRtKzeyRuXJqjG5bZBc-D5Teb-zso6Gmf_cn5LfcUM2bdQDFx5_n8QHzEyXnkM8XDHF3iOIXMHjLtol6mR_JZq5cRIw9xiz4d5JPT9Iq9sDgmen2aV-z-86e79Zdi8_Xmdv1xU-gaalWAxkFXSJ0VZNBUQ2tMa2tBpa0JlLJdW4I0pW0aU-FgpGoqsCAtQWexQ7hi74_efQw_FkpzP7mkaRzRU1hSX4IAVYsGIKPv_kN3YYn5Y3-oDkpRQZMpcaR0DClFsv0-ugnjz16K_lBMfy6mr_JGqHzy9iRehpycD_42kYH1EdilGbd0BjDOTo_0r7E-ac-pfsDYk4ffivGnJQ</recordid><startdate>20191001</startdate><enddate>20191001</enddate><creator>IWANAGA, Toshihiko</creator><creator>KONNO, Kohtarou</creator><creator>WATANABE, Masahiko</creator><general>Biomedical Research Press</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20191001</creationdate><title>Selective distribution of GLUT3-expressing nerve fibers in the lamina terminalis among the circumventricular organs of mice</title><author>IWANAGA, Toshihiko ; KONNO, Kohtarou ; WATANABE, Masahiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5357-3cabc4ae9f0edad4b8dd8f50e2f5e377f98231d2f66d4abd17643f31fe39fa9a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animals</topic><topic>Anterior commissure</topic><topic>Area postrema</topic><topic>Biomarkers</topic><topic>Circumventricular Organs - metabolism</topic><topic>Disease Models, Animal</topic><topic>Female</topic><topic>Fibers</topic><topic>Fluorescent Antibody Technique</topic><topic>Gene Expression</topic><topic>Glucose metabolism</topic><topic>Glucose Transporter Type 3 - genetics</topic><topic>Hypothalamus - metabolism</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Mice</topic><topic>Nerve endings</topic><topic>Nerve Fibers - metabolism</topic><topic>Organs</topic><topic>Osmosis</topic><topic>Preoptic area (medial)</topic><topic>Rodents</topic><topic>Sense organs</topic><topic>Subfornical organ</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>IWANAGA, Toshihiko</creatorcontrib><creatorcontrib>KONNO, Kohtarou</creatorcontrib><creatorcontrib>WATANABE, Masahiko</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biomedical Research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>IWANAGA, Toshihiko</au><au>KONNO, Kohtarou</au><au>WATANABE, Masahiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Selective distribution of GLUT3-expressing nerve fibers in the lamina terminalis among the circumventricular organs of mice</atitle><jtitle>Biomedical Research</jtitle><addtitle>Biomed. Res.</addtitle><date>2019-10-01</date><risdate>2019</risdate><volume>40</volume><issue>5</issue><spage>207</spage><epage>214</epage><pages>207-214</pages><issn>0388-6107</issn><eissn>1880-313X</eissn><abstract>Sensory circumventricular organs contain the subfornical organ, organum vasculosum of the lamina terminalis (OVLT), and area postrema. Here, immunostaining for GLUT3 in the murine brain selectively labeled the sobfornical organ and OVLT. The immunoreactive neural tract of the subfornical organ formed into thin bundles and extended ventro-rostrally over the anterior commissure. After turning over the commissure, the neural tract passed through the median preoptic nucleus (MnPO) and reached the OVLT; thus, a continuous neural tract expressing GLUT3 connected the subfornical organ, MnPO, and OVLT in the lamina terminalis. In the OVLT, GLUT3-immunoreactive fibers gathered in both the dorsal cap and lateral periventricular zone. Electron microscopically, the immunoreactive structures in the subfornical organ corresponded to nerve fibers or nerve terminals containing many small clear vesicles. The area postrema, another sensory organ, was immunonegative for GLUT3. This study not only presented a useful marker tracing the neural tract in the sensory sites of the lamina terminalis but also suggested a unique system for sensing and determining the metabolism of circulating glucose in the circumventricular organs.</abstract><cop>Japan</cop><pub>Biomedical Research Press</pub><pmid>31597906</pmid><doi>10.2220/biomedres.40.207</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0388-6107 |
| ispartof | Biomedical Research, 2019/10/01, Vol.40(5), pp.207-214 |
| issn | 0388-6107 1880-313X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2303750633 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese |
| subjects | Animals Anterior commissure Area postrema Biomarkers Circumventricular Organs - metabolism Disease Models, Animal Female Fibers Fluorescent Antibody Technique Gene Expression Glucose metabolism Glucose Transporter Type 3 - genetics Hypothalamus - metabolism Immunohistochemistry Male Mice Nerve endings Nerve Fibers - metabolism Organs Osmosis Preoptic area (medial) Rodents Sense organs Subfornical organ |
| title | Selective distribution of GLUT3-expressing nerve fibers in the lamina terminalis among the circumventricular organs of mice |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T17%3A44%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Selective%20distribution%20of%20GLUT3-expressing%20nerve%20fibers%20in%20the%20lamina%20terminalis%20among%20the%20circumventricular%20organs%20of%20mice&rft.jtitle=Biomedical%20Research&rft.au=IWANAGA,%20Toshihiko&rft.date=2019-10-01&rft.volume=40&rft.issue=5&rft.spage=207&rft.epage=214&rft.pages=207-214&rft.issn=0388-6107&rft.eissn=1880-313X&rft_id=info:doi/10.2220/biomedres.40.207&rft_dat=%3Cproquest_cross%3E2303750633%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2309320436&rft_id=info:pmid/31597906&rfr_iscdi=true |