Two-level approaches to missing data in longitudinal trials with daily patient-reported outcomes

In longitudinal clinical trials with daily patient-reported outcomes, the analysis endpoints are often defined as the averaged daily diary outcomes in a treatment cycle (such as a month or a week). Conventional methods often deal with missing data at the cycle level by imputing the average, and the...

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Veröffentlicht in:	Statistical methods in medical research 2020-07, Vol.29 (7), p.1935-1949
Hauptverfasser:	Jin, Man, Feng, Dai, Liu, Guanghan, Wan, Shuyan
Format:	Artikel
Sprache:	eng
Schlagworte:	Bias Clinical outcomes Clinical research Clinical trials Computer simulation Imputing Insomnia Missing data Simulation
Online-Zugang:	Volltext
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